公开(公告)号：WO1997032714A1

公开(公告)日：1997-09-12

申请号：PCT/US1997003251

申请日：1997-03-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SHANNON, Donald ,  MCINTYRE, John ,  KUO, Chris ,  MCCOLLAM, Chris ,  PETERSON, Robert

IPC: B29C55/18

CPC classification number: B29C55/045 ,  B29C55/10 ,  B29C55/18 ,  B29K2027/18

Abstract: Porous fluoropolymer films, such as PTFE films, formed by a method comprising the steps of (a) forming a fluoropolymer (e.g., PTFE) paste (10), (b) extruding, calendaring, or otherwise processing the paste to form a film extrudate (12), (c) causing the film extrudate to be calendared in a first directional axis (14), (d) subsequently calendaring the film extrudate in a second directional axis which is different form the first directional axis (16), (e) subsequently calendaring the film extrudate in at least one additional direction axis which is different from said first and second directional axes, thereby forming a multiaxially calendared film extrudate (18), (f) drying the multiaxially calendared film extrudate (20), and (g) radially expanding the multiaxially calendared film extrudate (22) to form a radially oriented fluoropolymer (e.g., PTFE) film. The porous fluoropolymer films formed by this method are multiaxially oriented and exhibit isotropic strength properties.

Abstract translation: 通过包括以下步骤（a）形成含氟聚合物（例如PTFE）糊剂（10）的方法形成的PTFE薄膜的多孔含氟聚合物膜，（b）挤出，压延或以其它方式处理该糊料以形成膜挤出物 （12），（c）使膜挤出物在第一方向轴线（14）上压延，（d）随后在与第一方向轴线（16）不同的第二方向轴上压延膜挤出物，（e 随后在不同于所述第一和第二方向轴的至少一个附加方向轴上压延所述膜挤出物，从而形成多轴压延膜挤出物（18），（f）干燥所述多轴压延膜挤出物（20）和（ g）径向膨胀多轴压延膜挤出物（22）以形成径向取向的含氟聚合物（例如，PTFE）膜。 通过该方法形成的多孔含氟聚合物膜是多轴取向的并且具有各向同性的强度特性。

公开(公告)号：WO1996033066A1

公开(公告)日：1996-10-24

申请号：PCT/US1996005165

申请日：1996-04-15

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SHANNON, Donald ,  McINTYRE, John ,  KUO, Chris ,  McCOLLAM, Chris ,  PETERSON, Robert

IPC: B29D23/00

CPC classification number: B29D23/001 ,  A61F2/06 ,  Y10S623/901

Abstract: A method for improving the radial enlargeability and other properties of tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. Broadly, the method comprises the step of radially shrinking the reinforcement tape layer of the graft, or the entire tape-reinforced graft, after sintering thereof. Such radial shrinkage of the reinforcement tape layer, or of the entire graft, renders the graft subsequently radially enlargeable by more than 5 %, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.

Abstract translation: 一种用于改善由烧结的含氟聚合物（例如膨胀的烧结PTFE）形成的带状管状血管移植物的径向扩大性等的性质的方法。 广泛地，该方法包括在烧结之后径向收缩移植物的加强带层或整个带增强移植物的步骤。 加强带层或整个移植物的这种径向收缩使得移植物随后可以径向放大超过5％，而不会撕裂或破坏移植物的加强带层。 本发明的可径向扩大的移植物可以与各种类型的支架或锚固系统组合，以形成可以可插入并且可植入到宿主血管腔内的血管内移植装置。 或者，本发明的径向可放大的移植物可以通过传统的手术移植物植入技术植入，而在植入时没有移植物的任何径向扩大，从而利用改进的强度性质和缝线保持性能 本发明的径向缩小的带状增强移植物。

公开(公告)号：WO1996040001A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009748

申请日：1996-06-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MCINTYRE, John ,  SHANNON, Donald ,  KUO, Chris ,  MCCOLLAM, Chris ,  PETERSON, Robert

IPC: A61F02/06

CPC classification number: A61F2/06 ,  Y10S623/901

Abstract: An externally supported, tape-reinforced tubular prosthetic graft and method of manufacturing therefore. The graft comprises a tubular base graft formed of expanded, sintered fluoropolymer material, a strip of reinforcement tape helically wrapped about the outer surface of the tubular base graft and attached thereto, and, an external support member helically wrapped around the outer surface of the reinforcement tape and attached thereto. The helical pitch of the reinforcement tape is different from the helical pitch of the external support member. Preferably, the helical pitch of the reinforcement tape is in a direction which is opposite the direction of the external support member.

Abstract translation: 外部支撑的带状增强管状假体移植物及其制造方法。 移植物包括由膨胀的，烧结的氟聚合物材料形成的管状基底移植物，螺旋缠绕在管状基底移植物的外表面上并附接到其上的加强带条，以及螺旋缠绕在加强件的外表面上的外部支撑构件 胶带并附着于其上。 加强带的螺距不同于外部支撑构件的螺距。 优选地，加强带的螺距在与外部支撑构件的方向相反的方向上。

公开(公告)号：WO1996034911A1

公开(公告)日：1996-11-07

申请号：PCT/US1996006083

申请日：1996-05-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SHANNON, Donald ,  KUO, Chris ,  PETERSON, Robert ,  MCCOLLAM, Chris

IPC: C08J05/18

CPC classification number: B29C55/005 ,  B29C43/006 ,  B29C43/24 ,  B29K2027/18

Abstract: A method for preparing thin fluoropolymer (PTFE) films, said method generally comprising the steps of: a) providing an unsintered fluoropolymer film; b) pre-sintering expansion of the film; c) sintering the expanded film with dimensional restraint to prevent shrinkage; and d) post-sintering stretching of the film to a final thickness preferably less than 0.002 inches. The post-sintering stretching of the film in step d may be accomplished in a single step, or may comprise a series of post-sintering stretching steps. Steps b and c of the method may be carried out by passing the calendared film through a machine direction orienter device and, thereafter, step d of the method may be accomplished by subsequently repassing the sintered film through the machine direction orienter device, one or more additional times.

Abstract translation: 一种制备薄氟聚合物（PTFE）膜的方法，所述方法通常包括以下步骤：a）提供未烧结的含氟聚合物膜; b）预烧结膜的膨胀; c）用尺寸限制烧结膨体膜以防止收缩; 以及d）将所述膜的后烧结拉伸至优选小于0.002英寸的最终厚度。 步骤d中的膜的后烧结拉伸可以在单个步骤中完成，或者可以包括一系列后烧结拉伸步骤。 该方法的步骤b和c可以通过使压延膜通过机器方向定向装置来进行，此后，该方法的步骤d可以通过随后通过机器方向定向装置重新安装烧结膜来实现，一个或多个 额外的时间。

公开(公告)号：EP0958125A1

公开(公告)日：1999-11-24

申请号：EP97907976.0

申请日：1997-03-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： SHANNON, Donald ,  MCINTYRE, John ,  KUO, Chris ,  MCCOLLAM, Chris ,  PETERSON, Robert

IPC: B29C55

CPC classification number: B29C55/045 ,  B29C55/10 ,  B29C55/18 ,  B29K2027/18

Abstract: Porous fluoropolymer films, such as PTFE films, formed by a method comprising the steps of (a) forming a fluoropolymer (e.g., PTFE) paste (10), (b) extruding, calendaring, or otherwise processing the paste to form a film extrudate (12), (c) causing the film extrudate to be calendared in a first directional axis (14), (d) subsequently calendaring the film extrudate in a second directional axis which is different form the first directional axis (16), (e) subsequently calendaring the film extrudate in at least one additional direction axis which is different from said first and second directional axes, thereby forming a multiaxially calendared film extrudate (18), (f) drying the multiaxially calendared film extrudate (20), and (g) radially expanding the multiaxially calendared film extrudate (22) to form a radially oriented fluoropolymer (e.g., PTFE) film. The porous fluoropolymer films formed by this method are multiaxially oriented and exhibit isotropic strength properties.

公开(公告)号：EP0823924A1

公开(公告)日：1998-02-18

申请号：EP96915431.0

申请日：1996-05-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： SHANNON, Donald ,  KUO, Chris ,  PETERSON, Robert ,  McCOLLAM, Chris

IPC: C08J5 ,  B29C55 ,  B29C67 ,  C08J9 ,  B29C43 ,  B29K27 ,  B29K105 ,  B29L7

CPC classification number: B29C55/005 ,  B29C43/006 ,  B29C43/24 ,  B29K2027/18

Abstract: A method for preparing thin fluoropolymer (PTFE) films, said method generally comprising the steps of: a) providing an unsintered fluoropolymer film; b) pre-sintering expansion of the film; c) sintering the expanded film with dimensional restraint to prevent shrinkage; and d) post-sintering stretching of the film to a final thickness preferably less than 0.002 inches. The post-sintering stretching of the film in step d may be accomplished in a single step, or may comprise a series of post-sintering stretching steps. Steps b and c of the method may be carried out by passing the calendared film through a machine direction orienter device and, thereafter, step d of the method may be accomplished by subsequently repassing the sintered film through the machine direction orienter device, one or more additional times.

公开(公告)号：EP0830110A1

公开(公告)日：1998-03-25

申请号：EP96919276.0

申请日：1996-06-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： MCINTYRE, John ,  SHANNON, Donald ,  KUO, Chris ,  MCCOLLAM, Chris ,  PETERSON, Robert

IPC: A61F2

CPC classification number: A61F2/06 ,  Y10S623/901

Abstract: An externally supported, tape-reinforced tubular prosthetic graft and method of manufacturing therefore. The graft comprises a tubular base graft formed of expanded, sintered fluoropolymer material, a strip of reinforcement tape helically wrapped about the outer surface of the tubular base graft and attached thereto, and, an external support member helically wrapped around the outer surface of the reinforcement tape and attached thereto. The helical pitch of the reinforcement tape is different from the helical pitch of the external support member. Preferably, the helical pitch of the reinforcement tape is in a direction which is opposite the direction of the external support member.

公开(公告)号：EP0821648A1

公开(公告)日：1998-02-04

申请号：EP96912756.0

申请日：1996-04-15

Applicant: BAXTER INTERNATIONAL INC.

Inventor： SHANNON, Donald ,  McINTYRE, John ,  KUO, Chris ,  McCOLLAM, Chris ,  PETERSON, Robert

IPC: A61F2 ,  B29D23

CPC classification number: B29D23/001 ,  A61F2/06 ,  Y10S623/901

Abstract: A method for improving the radial enlargeability and other properties of tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. Broadly, the method comprises the step of radially shrinking the reinforcement tape layer of the graft, or the entire tape-reinforced graft, after sintering thereof. Such radial shrinkage of the reinforcement tape layer, or of the entire graft, renders the graft subsequently radially enlargeable by more than 5 %, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.