公开(公告)号：WO2014144868A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/029460

申请日：2014-03-14

Applicant: BECKMAN COULTER, INC.

Inventor： GRAHAM, Marshall Donnie ,  GRAHAM, William Gerry ,  CLARKIN, James P. ,  WELLS, Mark A. ,  CANO, Jose M. ,  ARBOLEDA, Carlos Alberto ,  SANCHEZ, Armando J.

IPC: G01N15/14 ,  C03B23/047

CPC classification number: G01N21/05 ,  C03B23/047 ,  C03C27/00 ,  G01N15/1434 ,  G01N2015/1006 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2201/02 ,  Y02P40/57

Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.

Abstract translation: 一种改进的光学流通池，适用于流式细胞仪，用于分离液体悬浮液中的成形体（例如血细胞）。 优选通过组装，对准和光学地连接由透明材料制成的至少两个元件来制造，改进的流动池具有在圆柱形第一元件中优选非圆形横截面的无缝内部流动通道，通过该圆形第一元件可以计量准备的样品， 独立的第二元件具有适合于在这种悬架中从成形体获取光学参数的外部包络线，所述第二元件与第一元件一致并对齐，使得对通过流动的成形体的光学特性参数的非轴对称折射效应 在两个元件以工作空间关系被光学地连接和固定之前，第一元件中的通道可以被最小化。

公开(公告)号：WO2010151522A1

公开(公告)日：2010-12-29

申请号：PCT/US2010/039440

申请日：2010-06-22

Applicant: BECKMAN COULTER, INC. ,  PEREZ, Carlos A. ,  CANO, Jose M. ,  SCHORSCH, Joe C. ,  VARGAS, Viviana A.

Inventor： PEREZ, Carlos A. ,  CANO, Jose M. ,  SCHORSCH, Joe C. ,  VARGAS, Viviana A.

IPC: G01N35/08 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N35/0092 ,  G01N35/085 ,  G01N35/1004 ,  G01N35/1097 ,  G01N2035/00326 ,  G01N2035/0093 ,  Y10T436/11 ,  Y10T436/2575

Abstract: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers. The presented methods include steps for repeated processing of prepared blood samples through the blood analyzing instrument.

Abstract translation: 用于血液分析仪器的流水线组件，用于执行平行流水线功能的方法，以及通过血液分析仪器处理多个准备的血液样本的方法。 流水线组件通常包括第一样品制备室，与第一样品制备室流体连通的第一排队室，以及在第一样品制备室和第一排队室之间的第一控制阀。 流水线组件还包括第二样品制备室，与第二样品制备室流体连通的第二排列室，以及在第二样品制备室和第二排列室之间的第二控制阀。 提供分析室以从第一和第二排队室接收第一和第二准备的血液样本。 所提出的方法包括通过血液分析仪器重复处理制备的血液样品的步骤。

公开(公告)号：EP2076766A1

公开(公告)日：2009-07-08

申请号：EP07814726.1

申请日：2007-09-07

Applicant: Beckman Coulter, Inc.

Inventor： GONZALEZ, Carlos R. ,  LI, William W. ,  CASEY, William J. ,  VEINER, Craig R. ,  CANO, Jose M. ,  DEL VALLE, Roberto ,  GALVEZ, Santiago

IPC: G01N30/20

CPC classification number: G01N35/1097

Abstract: Apparatus (20) for aspirating and dispensing liquid samples in an analytical instrument, e g, a hematology instrument, includes a liquid-sampling valve (LSV) that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has been aspirated into the valve by a pump (30), simultaneously enables the apparatus to be operated in an aspirate/dispense (suck-and-spit) mode in which a liquid sample can be selectively driven through the valve in opposite directions by a pump, e g, a syringe pump.

公开(公告)号：EP2972209B1

公开(公告)日：2019-08-28

申请号：EP14721665.9

申请日：2014-03-14

Applicant: Beckman Coulter, Inc.

Inventor： GRAHAM, Marshall Donnie ,  GRAHAM, William Gerry ,  CLARKIN, James P. ,  WELLS, Mark A. ,  CANO, Jose M. ,  ARBOLEDA, Carlos Alberto ,  SANCHEZ, Armando J.

IPC: G01N15/14 ,  C03B23/047 ,  C03C27/00 ,  G01N21/05 ,  G01N15/10

公开(公告)号：EP2446277A1

公开(公告)日：2012-05-02

申请号：EP10729000.9

申请日：2010-06-22

Applicant: Beckman Coulter, Inc.

Inventor： PEREZ, Carlos A. ,  CANO, Jose M. ,  SCHORSCH, Joe C. ,  VARGAS, Viviana A.

IPC: G01N35/08 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N35/0092 ,  G01N35/085 ,  G01N35/1004 ,  G01N35/1097 ,  G01N2035/00326 ,  G01N2035/0093 ,  Y10T436/11 ,  Y10T436/2575

Abstract: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers. The presented methods include steps for repeated processing of prepared blood samples through the blood analyzing instrument.

公开(公告)号：EP2972209A1

公开(公告)日：2016-01-20

申请号：EP14721665.9

申请日：2014-03-14

Applicant: Beckman Coulter, Inc.

Inventor： GRAHAM, Marshall Donnie ,  GRAHAM, William Gerry ,  CLARKIN, James P. ,  WELLS, Mark A. ,  CANO, Jose M. ,  ARBOLEDA, Carlos Alberto ,  SANCHEZ, Armando J.

IPC: G01N15/14 ,  C03B23/047

CPC classification number: G01N21/05 ,  C03B23/047 ,  C03C27/00 ,  G01N15/1434 ,  G01N2015/1006 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2201/02 ,  Y02P40/57

Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.

Abstract translation: 改进的光学流通池适用于流式细胞仪，用于分离液体悬浮液中的成形体（例如血细胞）。 优选地，通过组装，对准和光学地连接由透明材料制成的至少两个元件制造，改进的流动池具有在圆柱形第一元件中优选非圆形横截面的无缝内部流动通道，通过该圆形第一元件可以计量准备的样品， 独立的第二元件具有适合于在这种悬架中从成形体获取光学参数的外部包络线，第二元件与第一元件一致并对准，使得对通过流动的成形体的光学特性参数的非轴对称折射效应 在两个元件以工作空间关系被光学连接和固定之前，第一元件中的通道可以被最小化。