公开(公告)号：US3562130A

公开(公告)日：1971-02-09

申请号：US3562130D

申请日：1968-04-12

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HOOLE DUANE W ,  KLEIN GERALD L

IPC: G01N27/333 ,  G01N27/46

CPC classification number: G01N27/333

Abstract: ION SENSITIVE COMBINATION ELECTROCHEMICAL ELECTRODES FORMED PRIMARILY OF PLASTIC WITHOUT THE USE OF GLASS WITHIN THE STRUCTURES ARE DISCLOSED. IN ONE EMBODIMENT AN ION SENSITIVE MEMBRANE SUCH AS A LAF3 CRYSTAL IS IN CONTACT WITH A COPPER TUBE CONTAINING AN ELECTROLYTE, THE COPPER TUBE BEING BONDED TO THE LAF3 CRYSTAL. THE COPPER TUBE AND LATERAL SURFACE OF THE LAF3 ARE COATED WITH A PLASTIC TO PROVIDE ELECTRICAL INSULATION AND A SEAL AGAINST LIQUID. A SECOND EMBODIMENT INCLUDES A PLASTIC TUBE SUPPORTING A SILVER CHLORIDE COATED SILVER WIRE WITH AN ELECTROLYTE BEING DISPOSED WITHIN THE TUBE IN CONTACT WITH A LAF3 CRYSTAL. A COMPRESSION RING IS FORMED ABOUT THE PLASTIC TUBE AND THE LAF3 CRYSTAL TO PROVIDE A BIASING FORCE HOLDING THE TUBE AND THE CRYSTAL IN A SEALED RELATIONSHIP. IN EACH EMBODIMENT A FLUSH SENSING SURFACE INCLUDING A LIQUID JUNCTION STRUCTURE IS PROVIDED.

公开(公告)号：US3575834A

公开(公告)日：1971-04-20

申请号：US3575834D

申请日：1968-04-12

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HOOLE DUANE W ,  KLEIN GERALD L ,  VIVIAN TERRY R

IPC: G01N27/28 ,  G01N27/401 ,  G01N27/46

CPC classification number: G01N27/28 ,  G01N27/401

Abstract: LIQUID JUNCTION STRUCTURES FOR PLASTIC ELECTROCHEMICAL ELECTRODES AND METHODS OF MANUFACTURING THE SAME ARE DISCLOSED. ONE EMBODIMENT COMPRISES A TUBE OF PLASTIC HAVING AN OPEN END WITH AN ION SENSITIVE STRUCTURE MOUNTED THEREIN. A SMALL LONGITUDINAL CHANNEL IS FORMED IN THE TUBE WHICH EXTENDS FROM THE OPEN END PAST THE MEMBRANE TO OPEN INTO THE INTERIOR OF THE TUBE. A BUNDLE OF FIBERS IS POSITIONED IN THE CHANNEL COVERED BY A SLEEVE OF INJECTION MOLDED PLASTIC FOR COMPACTING AND RESTRAINING THE FIBERS. THE EMBODIMENT ENABLES A PLANAR SENSING SURFACE FOR A PLASTIC COMBINATION ELECTRODE. ANOTHER EMBODIMENT COMPRISES A TUBE HVING AN EXTENDED LIP PORTION SURROUNDING AN OPENING AND A SHRINK TUBE SURROUNDING THE LIP PORTION. A BUNDLE OF FIBERS IS POSITIONED IN THE OPENING; THEREAFTER THE LIP PORTION AND THE SHRINK TUBE ARE HEATED TO MELT AND CONTRACT THE LIP PORTION AND THE SHRINK TUBE RESPECTIVELY ABOUT THE FIBERS.

公开(公告)号：AU652096B2

公开(公告)日：1994-08-11

申请号：AU3696293

申请日：1993-04-15

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  MILLER GARY A

IPC: G01N27/447 ,  G01N35/04 ,  G01N35/02

Abstract: An automated multi-channel capillary electrophoresis analyzer includes a plurality of capillaries having first and second ends. The first ends of the capillaries are adapted to be collectively transported to and from selected reagent reservoirs. The second ends of the capillaries are removably and sealable retained within a common manifold that is in turn in selectable fluid communication with selected reagents and a vacuum source.

公开(公告)号：AU4168293A

公开(公告)日：1994-02-10

申请号：AU4168293

申请日：1993-06-30

Applicant: BECKMAN INSTRUMENTS INC

Inventor： WASKA FRANKLYN L ,  KLEIN GERALD L ,  JOHNSON WAYNE S

IPC: G01N21/17 ,  G01N27/447 ,  G01N33/48

Abstract: Detecting light in a capillary electrophoresis optical system includes input and output windows in the outside surface of a capillary tube. The width of the windows is not substantially greater than the bore of the tube. A fiber optic input is spaced from the capillary tube so that the light is directed to the tube and is matched to the window width. The light output from the tube is matched to be received by a fiber optic output spaced from the capillary tube. The optical light envelop from the fiber input through the tube and to the fiber output is governed by the LaGrange Invariant. The matching is effected in accordance with the Numerical Aperture of the fiber optics.

公开(公告)号：AU3876993A

公开(公告)日：1994-01-20

申请号：AU3876993

申请日：1993-05-24

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LIU CHENG-MING ,  WANG HANN-PING ,  CHEN FU-TAI ALBERT ,  STERNBERG JAMES C ,  KLEIN GERALD L

IPC: B26D5/22 ,  B26F1/02 ,  B65H20/24 ,  G01N33/577 ,  G01N33/558 ,  G01N33/561 ,  G01N33/564

Abstract: A method for perforating a sheet material provides for a perforating die located intermediate two orbital rollers. The two orbital rollers move in orbital paths in the same orbital direction at the same speed and in positions which are 180 degrees apart. Each roller acts as a temporary storage input and output in opposite phase from each other so that incoming sheet material is alternately stored and dispensed as a loop on the orbital roller. Since the rollers are out of phase, this permits a segment of the sheet material to be stopped intermediate the orbital rollers so that the perforating die can act on the stopped segment.

公开(公告)号：DE69320273D1

公开(公告)日：1998-09-17

申请号：DE69320273

申请日：1993-05-17

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LIU CHING-MING ,  WANG HANN-PING ,  CHEN FU-TAI ALBERT ,  STERNBERG JAMES C ,  KLEIN GERALD L

IPC: G01N27/447 ,  G01N33/53 ,  G01N33/561 ,  G01N33/68

Abstract: Disclosed herein are methodologies for the Capillary Electrophoretic Immunosubtraction ("CEI") of samples. In a preferred embodiment, CEI of a sample comprising constituent parts to be separated comprises the steps of: (1) separating a first aliquot of the sample into constituent parts by capillary electrophoretic techniques, and detecting said parts; (2) admixing a second aliquot of said sample with at least one specific binding partner to a constituent of said sample, said specific binding partner capable of being substantially removed from said aliquot; (3) separating said second aliquot into constituent parts by capillary electrophoretic techniques and detecting said parts; and (4) comparing the separated constituent parts of step (3) with the separated constituent parts of step (1).

公开(公告)号：AT169737T

公开(公告)日：1998-08-15

申请号：AT93303805

申请日：1993-05-17

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LIU CHING-MING ,  WANG HANN-PING ,  CHEN FU-TAI ALBERT ,  STERNBERG JAMES C ,  KLEIN GERALD L

IPC: G01N27/447 ,  G01N33/53 ,  G01N33/561 ,  G01N33/68

Abstract: Disclosed herein are methodologies for the Capillary Electrophoretic Immunosubtraction ("CEI") of samples. In a preferred embodiment, CEI of a sample comprising constituent parts to be separated comprises the steps of: (1) separating a first aliquot of the sample into constituent parts by capillary electrophoretic techniques, and detecting said parts; (2) admixing a second aliquot of said sample with at least one specific binding partner to a constituent of said sample, said specific binding partner capable of being substantially removed from said aliquot; (3) separating said second aliquot into constituent parts by capillary electrophoretic techniques and detecting said parts; and (4) comparing the separated constituent parts of step (3) with the separated constituent parts of step (1).

公开(公告)号：AU3707293A

公开(公告)日：1994-01-20

申请号：AU3707293

申请日：1993-04-21

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  KATZMANN STEVEN P

IPC: G01N27/447 ,  G09F9/37 ,  G06F15/42

Abstract: A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected graphic values are displayed with respect to time. The selected graphic values may comprise a range hues, color saturation and/or brightness or may represent a monochromatic scale. The resulting representation may be horizontally aligned with the corresponding electrophoretogram absorbance values to provide both a quantitative value (electrophoretogram absorbance values) and qualitative (graphic stripe) display.

公开(公告)号：CA2099511A1

公开(公告)日：1994-01-18

申请号：CA2099511

申请日：1993-07-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： WASKA FRANK L ,  KLEIN GERALD L ,  JOHNSON WAYNE S

IPC: G01N21/17 ,  G01N27/447

Abstract: Detecting light in a capillary electrophoresis optical system includes input and output windows in the outside surface of a capillary tube. The width of the windows is not substantially greater than the bore of the tube. A fiber optic input is spaced from the capillary tube so that the light is directed to the tube and is matched to the window width. The light output from the tube is matched to be received by a fiber optic output spaced from the capillary tube. The optical light envelop from the fiber input through the tube and to the fiber output is governed by the LaGrange Invariant. The matching is effected in accordance with the Numerical Aperture of the fiber optics.

公开(公告)号：CA2094343A1

公开(公告)日：1994-01-18

申请号：CA2094343

申请日：1993-04-19

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  KATZMANN STEVEN P

IPC: G01N27/447 ,  G09F9/37 ,  G01N35/02

Abstract: A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected graphic values are displayed with respect to time. The selected graphic values may comprise a range hues, color saturation and/or brightness or may represent a monochromatic scale. The resulting representation may be horizontally aligned with the corresponding electrophoretogram absorbance values to provide both a quantitative value (electrophoretogram absorbance values) and qualitative (graphic stripe) display.