公开(公告)号：AU700988B2

公开(公告)日：1999-01-14

申请号：AU7118096

申请日：1996-09-25

Applicant: BECKMAN INSTRUMENTS INC

Inventor： NEAL JACK D MC ,  BELL MICHAEL L

IPC: G01N33/48 ,  B01L3/14 ,  B04B7/08 ,  G01N33/49

公开(公告)号：AU1530497A

公开(公告)日：1997-08-11

申请号：AU1530497

申请日：1997-01-08

Applicant: BECKMAN INSTRUMENTS INC

Inventor： COASSIN PETER J ,  NEAL JACK D MC ,  HELPHREY DAVID B

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00

Abstract: An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.

公开(公告)号：AU7118096A

公开(公告)日：1997-04-28

申请号：AU7118096

申请日：1996-09-25

Applicant: BECKMAN INSTRUMENTS INC

Inventor： NEAL JACK D MC ,  BELL MICHAEL L

IPC: G01N33/48 ,  B01L3/14 ,  B04B7/08 ,  G01N33/49

Abstract: A method for rapid separation of serum or plasma from cells in a whole blood sample uses a cylindrical sample tube having longitudinally-extending internal ribs. A separation gel and the sample are introduced into the tube, and the tube is axially centrifuged so as to form concentric shells of cells, gel, and serum or plasma. After centrifugation is stopped, the serum or plasma collects in the tube by gravity flow and the cells and gel remain affixed to the walls and ribs of the tube.

公开(公告)号：AU734126C

公开(公告)日：2002-01-03

申请号：AU1530497

申请日：1997-01-08

Applicant: BECKMAN INSTRUMENTS INC

Inventor： COASSIN PETER J ,  NEAL JACK D MC ,  HELPHREY DAVID B

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00

Abstract: An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.

公开(公告)号：AU734126B2

公开(公告)日：2001-06-07

申请号：AU1530497

申请日：1997-01-08

Applicant: BECKMAN INSTRUMENTS INC

Inventor： COASSIN PETER J ,  NEAL JACK D MC ,  HELPHREY DAVID B

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00

Abstract: An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.

公开(公告)号：AU7450296A

公开(公告)日：1997-05-07

申请号：AU7450296

申请日：1996-10-18

Applicant: BECKMAN INSTRUMENTS INC

Inventor： BELL MICHAEL L ,  NEAL JACK D MC

IPC: A61M5/162 ,  G01N35/10