公开(公告)号：AU7696487A

公开(公告)日：1988-01-29

申请号：AU7696487

申请日：1987-07-02

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER P ,  LAMOTTE GEORGE ,  THOMSON DAVID M P

IPC: C12N15/09 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/574 ,  G01N33/531 ,  G01N33/554

Abstract: Methods and compositions for diagnosing and monitoring patients suffering from neoplastic diseases, such as lung cancer. Peptide fragments embodying epitopic sites characteristic of organ-specific neoantigens capable of inducing leukocyte adherence inhibition have been prepared. The peptide fragments, and antibodies prepared from the fragments, are used to detect the OSN in patient specimens, particularly serum. Presence of the neoantigen in serum samples is diagnostic of the specific cancer. Various immunological techniques can be used to detect the neoantigen in such patient specimens. Alternatively, leukocyte adherence inhibition assays can be utilized using the purified peptides.