公开(公告)号：CA2818390C

公开(公告)日：2017-08-22

申请号：CA2818390

申请日：2011-11-18

Applicant: BIO-RAD LABORATORIES INC

Inventor： ARCHER ROBERT M ,  HSIUNG FRANK ,  PATT PAUL

IPC: C12Q1/04 ,  C12N5/07 ,  G01N1/28

Abstract: Adherent cells bearing characteristics that are detectable only in the adherent state can be sorted on the basis of these characteristics independently of their adherent state, by applying a transformable label to the entire population of cells, both those bearing the characteristics of interest and those not, in their adherent state and identifying the locations of the cells of interest on the adherent surface. The cells of interest, or all cells other than those of interest, are then selectively treated to transform the labels and achieve differentiation between the cells of interest and the remaining cells. All cells are then released from the adherent state and sorted in the same manner as non-adherent cells but on the basis of whether the labels are transformed or not transformed.

公开(公告)号：EP2992377A4

公开(公告)日：2017-03-08

申请号：EP14791630

申请日：2014-05-01

Applicant: BIO-RAD LABORATORIES INC

Inventor： HSIUNG FRANK ,  KROEGER KELLY ,  ARCHER ROBERT ,  KORTISOVA VERONIKA ,  RUBIO TERESA ,  SHEN ZUO CHENG ,  CHU DANIEL Y ,  DOE NICHOLAS ,  QUIROZ EMMANUEL

IPC: G02B21/06 ,  G01B9/02 ,  G02B21/24 ,  G02B21/36

CPC classification number: G02B21/368 ,  G02B21/241 ,  G02B21/365

Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.

公开(公告)号：EP2954102A4

公开(公告)日：2017-01-04

申请号：EP14748862

申请日：2014-02-05

Applicant: BIO-RAD LABORATORIES INC

Inventor： MCCOY ADAM M ,  TZONEV SVILEN ,  HSIUNG FRANK

IPC: C40B20/04 ,  C12Q1/00 ,  G01N33/542 ,  G01N33/58

CPC classification number: C12Q1/00 ,  G01N33/542 ,  G01N33/581

Abstract: The present invention provides methods of detecting a target molecule in a sample comprising incubating the sample with two or more detectably labeled probes, partitioning the sample into multiple partitions, and detecting the presence of the two or more probes in the same partition.

Abstract translation: 本发明提供检测样品中靶分子的方法，包括用两个或多个可检测标记的探针孵育样品，将样品分成多个分区，以及检测两个或更多个探针在同一分区中的存在。