公开(公告)号：WO2016004417A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/039150

申请日：2015-07-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： DI FRANCESCO, Maria, Emilia ,  JONES, Philip ,  HEFFERNAN, Timothy ,  ZHIJUN, Kang ,  SOTH, Michael, P ,  BURKE, Jason, P ,  CARROLL, Christopher Lawrence ,  MCAFOOS, Timothy ,  PALMER, Wylie, S. ,  HERRERA, Zachary ,  HAMILTON, Matthew

IPC: C07D401/06

CPC classification number: C07D401/06 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract translation: 本文公开了可用于治疗GLS1介导的疾病（例如癌症）的化合物和组合物，其具有式I的结构：还提供了人或动物受试者的抑制GLS1活性的方法。

公开(公告)号：WO2017004359A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/040364

申请日：2016-06-30

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： LEWIS, Richard, Thomas ,  JONES, Philip ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  HAMILTON, Matthew ,  SOTH, Michael, J. ,  HEFFERNAN, Timothy ,  HAN, Michelle ,  BURKE, Jason, P.

IPC: A61K31/501 ,  C07D417/14 ,  C07D207/00

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  A61K2300/00

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLSl mediated diseases, such as cancer, having the structure of Formula (I). Methods of inhibition GLSl activity in a human or animal subject are also provided.

Abstract translation: 本文公开了可用于治疗具有式（I）结构的GLS1介导的疾病例如癌症的化合物和组合物。 还提供了抑制人或动物受试者的GLS1活性的方法。

公开(公告)号：WO2016004404A2

公开(公告)日：2016-01-07

申请号：PCT/US2015/039134

申请日：2015-07-02

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： DI FRANCESCO, Maria, Emilia ,  JONES, Philip ,  HEFFERNAN, Timothy ,  HAMILTON, Matthew ,  KANG, Zhijun ,  SOTH, Michael, P. ,  BURKE, Jason, P. ,  LE, Kang ,  CARROLL, Christopher, Lawrence ,  PALMER, Wylie ,  LEWIS, Richard ,  MCAFOOS, Timothy ,  CZAKO, Barbara ,  LIU, Gang ,  THEROFF, Jay ,  HERRERA, Zachary ,  YAU, Anne

IPC: C07D417/14 ,  A61K31/4439

CPC classification number: C07D417/14 ,  A61K31/4192 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D417/06 ,  C07D493/08

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract translation: 本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。 / p>