公开(公告)号：WO2016004404A2

公开(公告)日：2016-01-07

申请号：PCT/US2015/039134

申请日：2015-07-02

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： DI FRANCESCO, Maria, Emilia ,  JONES, Philip ,  HEFFERNAN, Timothy ,  HAMILTON, Matthew ,  KANG, Zhijun ,  SOTH, Michael, P. ,  BURKE, Jason, P. ,  LE, Kang ,  CARROLL, Christopher, Lawrence ,  PALMER, Wylie ,  LEWIS, Richard ,  MCAFOOS, Timothy ,  CZAKO, Barbara ,  LIU, Gang ,  THEROFF, Jay ,  HERRERA, Zachary ,  YAU, Anne

IPC: C07D417/14 ,  A61K31/4439

CPC classification number: C07D417/14 ,  A61K31/4192 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D417/06 ,  C07D493/08

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract translation: 本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。 / p>