公开(公告)号：ZA200504163B

公开(公告)日：2007-03-28

申请号：ZA200504163

申请日：2005-05-23

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： KIRKEN ROBERT A ,  KAHAN BARRY D ,  STEPKOWSKI STANISLAW M ,  WALDEMAR PRIEBE ,  IZABELA FOKT ,  SZYMON KOSINSKI

IPC: A61K20090101 ,  A61K31/12 ,  A61K31/13 ,  A61K31/21 ,  A61K31/335 ,  C07C225/12 ,  C07D20090101 ,  G01N33/50

Abstract: Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.