公开(公告)号：WO1998003174A1

公开(公告)日：1998-01-29

申请号：PCT/US1997012158

申请日：1997-07-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  FIRESTONE, Raymond, A.

IPC: A61K31/445

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/4468 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/454

Abstract: A method is provided for treating hematologic tumors and solid tumors, including certain types of leukemias and metastatic tumors, having high LDL requirements employing a delipidating agent such as an MTP inhibitor to substantially reduce LDL blood levels. In addition, a method is provided for treating tumors of the above types having high LDL requirements, especially hematologic tumors such as certain leukemias, employing a delipidating compound to substantially remove native LDL, and then administering a cytotoxic agent carried in reconstituted LDL.

Abstract translation: 提供了一种用于治疗血液肿瘤和实体瘤的方法，包括某些类型的白血病和转移性肿瘤，具有高LDL需求，使用脱脂剂如MTP抑制剂以显着降低LDL血液水平。 此外，提供了一种用于治疗具有高LDL要求的上述类型的肿瘤的方法，特别是血液学肿瘤例如某些白血病，使用去脂化合物基本上除去天然的LDL，然后给予重组的LDL中携带的细胞毒性剂。

公开(公告)号：WO1998019705A1

公开(公告)日：1998-05-14

申请号：PCT/US1997019851

申请日：1997-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  KING, Dalton ,  FIRESTONE, Raymond, A. ,  DUBOWCHIK, Gene, M.

IPC: A61K39/395

CPC classification number: C07K5/06086 ,  A61K38/00 ,  A61K47/641 ,  A61K47/65 ,  C07K5/0202 ,  C07K5/06026 ,  C07K5/06052 ,  C07K5/06078

Abstract: Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.

Abstract translation: 含有靶向配体如抗体，治疗活性药物和支链肽接头的缀合物。 支链肽接头含有两个或多个提供酶切位点的氨基酸部分。 能够与支链接头结合的药物数量对于每一代分支变化为2倍。

公开(公告)号：EP0941120A1

公开(公告)日：1999-09-15

申请号：EP97946428.0

申请日：1997-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KING, Dalton ,  FIRESTONE, Raymond, A. ,  DUBOWCHIK, Gene, M.

IPC: A61K38 ,  A61K39 ,  A61K47 ,  A61P35 ,  A61P43 ,  C07K5 ,  C07K7 ,  C07K14

CPC classification number: C07K5/06086 ,  A61K38/00 ,  A61K47/641 ,  A61K47/65 ,  C07K5/0202 ,  C07K5/06026 ,  C07K5/06052 ,  C07K5/06078

Abstract: Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.

公开(公告)号：EP0954313A1

公开(公告)日：1999-11-10

申请号：EP97932594.0

申请日：1997-07-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： FIRESTONE, Raymond, A.

IPC: A61K45 ,  A61K31 ,  A61P35 ,  A61P43

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/4468 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/454

Abstract: A method is provided for treating hematologic tumors and solid tumors, including certain types of leukemias and metastatic tumors, having high LDL requirements employing a delipidating agent such as an MTP inhibitor to substantially reduce LDL blood levels. In addition, a method is provided for treating tumors of the above types having high LDL requirements, especially hematologic tumors such as certain leukemias, employing a delipidating compound to substantially remove native LDL, and then administering a cytotoxic agent carried in reconstituted LDL.