公开(公告)号：WO1998024411A2

公开(公告)日：1998-06-11

申请号：PCT/US1997019929

申请日：1997-11-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  SALAZAR, Daniel, E.

IPC: A61K09/00

CPC classification number: A61K31/505 ,  A61K31/495 ,  A61K2300/00

Abstract: An improved method for orally administering buspirone to a human subject wherein the bioavailability of buspirone is increased and its elimination, metabolite formation, and variability of these pharmacokinetic parameters is decreased, the improvement comprises the concurrent administration of a sufficient amount of nefazodone to effect these pharmacokinetic changes for orally administered buspirone.

Abstract translation: 一种改进的方法用于将人螺旋体口服给予人类对象，其中丁螺环酮的生物利用度增加，并且其消除，代谢物形成和这些药代动力学参数的变异性降低，改善包括同时给予足量的奈法唑酮以实现这些药代动力学 口服丁螺环酮的变化。