公开(公告)号：JP2013209432A

公开(公告)日：2013-10-10

申请号：JP2013140738

申请日：2013-07-04

Applicant: Basf Se ,  ビーエーエスエフ ソシエタス・ヨーロピアBasf Se

Inventor： HEYDRICH GUNNAR ,  GRALLA GABRIELE ,  RAULS MATTHIAS DR ,  SCHMIDT-LEITHOFF JOACHIM ,  EBEL KLAUS DR ,  KRAUSE WOLFGANG DR ,  OEHLENSCHLAEGER STEFFEN ,  JAEKEL CHRISTOPH ,  FRIEDRICH MARKO ,  BERGNER EIKE JOHANNES ,  KASHANI-SHIRAZI NAWID ,  PACIELLO ROCCO

IPC: C07C29/156 ,  B01J31/28 ,  C07B53/00 ,  C07B61/00 ,  C07C35/12

CPC classification number: C07C29/56 ,  C07B2200/07 ,  C07C29/172 ,  C07C29/78 ,  C07C45/62 ,  C07C45/82 ,  C07C2601/14 ,  C07C2601/16 ,  C07C47/21 ,  C07C35/12 ,  C07C35/17

Abstract: PROBLEM TO BE SOLVED: To provide a method enabling to manufacture optically active menthol, desirably L-menthol and racemic menthol in a variety of quantity according to the demand without changing an enantioselective catalyst system and/or without excessively obtaining one of products for need of changing a reaction condition.SOLUTION: A method for producing menthol includes a process (a. 1) of obtaining a citronellal by catalyst-hydrogenation of a neral and/or a geranial, a process (b. 1) of obtaining an isopulegol by cyclizing citronellal in the presence of an acid catalyst, a process (c. 1) of purifying the isopulegol by crystallization, and a process (d. 1) of producing menthol by catalyst-hydrogenation of the isopulegol.

Abstract translation: 要解决的问题：提供一种能够根据需要以不需要改变对映体选择性催化剂体系，和/或不过度地获得需要的物质的产品之一来制备光学活性薄荷醇，理想的L-薄荷醇和外消旋薄荷醇， 改变反应条件。解决方案：制备薄荷醇的方法包括通过催化剂氢化和/或香草醛获得香茅醛的方法（a.1），通过环化获得异焦耳的方法（b.1） 在酸催化剂存在下的香茅醛，通过结晶纯化异焦耳的方法（c.1），以及通过异双胍的催化氢化制备薄荷醇的方法（d.1）。