公开(公告)号：WO1996039464A1

公开(公告)日：1996-12-12

申请号：PCT/US1996010249

申请日：1996-06-06

Applicant: C.R. BARD, INC. ,  LEHIGH UNIVERSITY

Inventor： C.R. BARD, INC. ,  LEHIGH UNIVERSITY ,  VANDERHOFF, John, W. ,  LU, Cheng, Xun ,  LEE, Clarence, C. ,  TSAI, Chi-Chun

IPC: C08J03/26

CPC classification number: C08J3/26 ,  C08J3/05 ,  C08J3/16 ,  C08J2300/14

Abstract: A process for the preparation of crosslinked water-soluble polymer particles comprising, combining an aqueous polymer solution comprising a water-soluble polymer, particularly a polysaccharide, and an aqueous medium, and an oil medium so as to form an emulsion of droplets of the water-soluble polymer, and adding to the emulsion a crosslinking agent capable of crosslinking the water-soluble polymer so as to form crosslinked water-soluble polymer particles, the particles formed thereby and aqueous dispersions thereof. The invention also encompasses a method comprising, administering to a patient in need of treatment an aqueous suspension of the water-soluble polymer particles.

Abstract translation: 一种制备交联的水溶性聚合物颗粒的方法，包括将包含水溶性聚合物，特别是多糖和含水介质的水性聚合物溶液和油介质混合，以形成水滴的乳液 并且向该乳液中添加能够使水溶性聚合物交联以形成交联的水溶性聚合物颗粒的交联剂，由此形成的颗粒及其水分散体。 本发明还包括一种方法，其包括向需要治疗的患者施用水溶性聚合物颗粒的水性悬浮液。

公开(公告)号：WO1995033511A1

公开(公告)日：1995-12-14

申请号：PCT/US1995007266

申请日：1995-06-07

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  LEE, Clarence, C.

IPC: A61M31/00

CPC classification number: A61K9/0024 ,  A61K9/0034 ,  A61K9/0092 ,  A61M31/002

Abstract: The present invention is an implantable device that is capable of delivering a therapeutic agent to a tissue or organ over a long period of time. The implantable device is especially suited for treating tissues and organs that are comprised of smooth muscle. The implantable device can deliver either a single therapeutic agent or a plurality of therapeutic agents to the tissue or organ at zero order kinetics.

Abstract translation: 本发明是能够长时间将治疗剂递送至组织或器官的可植入装置。 可植入装置特别适用于治疗由平滑肌组成的组织和器官。 可植入装置可以以零级动力学将单一治疗剂或多种治疗剂递送至组织或器官。

公开(公告)号：EP0830416A1

公开(公告)日：1998-03-25

申请号：EP96922457.0

申请日：1996-06-06

Applicant: C.R. BARD, INC. ,  LEHIGH UNIVERSITY

Inventor： VANDERHOFF, John, W. ,  LU, Cheng, Xun ,  LEE, Clarence, C. ,  TSAI, Chi-Chun

IPC: A61L27 ,  A61L31 ,  C08J3

CPC classification number: C08J3/26 ,  C08J3/05 ,  C08J3/16 ,  C08J2300/14

Abstract: A process for the preparation of crosslinked water-soluble polymer particles comprising, combining an aqueous polymer solution comprising a water-soluble polymer, particularly a polysaccharide, and an aqueous medium, and an oil medium so as to form an emulsion of droplets of the water-soluble polymer, and adding to the emulsion a crosslinking agent capable of crosslinking the water-soluble polymer so as to form crosslinked water-soluble polymer particles, the particles formed thereby and aqueous dispersions thereof. The invention also encompasses a method comprising, administering to a patient in need of treatment an aqueous suspension of the water-soluble polymer particles.

公开(公告)号：EP0830416B1

公开(公告)日：2005-08-31

申请号：EP96922457.5

申请日：1996-06-06

Applicant: C.R. BARD, INC. ,  LEHIGH UNIVERSITY

Inventor： VANDERHOFF, John, W. ,  LU, Cheng, Xun ,  LEE, Clarence, C. ,  TSAI, Chi-Chun

IPC: C08J3/26 ,  A61L31/00 ,  A61L27/00

CPC classification number: C08J3/26 ,  C08J3/05 ,  C08J3/16 ,  C08J2300/14

Abstract: A process for the preparation of crosslinked water-soluble polymer particles comprising, combining an aqueous polymer solution comprising a water-soluble polymer, particularly a polysaccharide, and an aqueous medium, and an oil medium so as to form an emulsion of droplets of the water-soluble polymer, and adding to the emulsion a crosslinking agent capable of crosslinking the water-soluble polymer so as to form crosslinked water-soluble polymer particles, the particles formed thereby and aqueous dispersions thereof. The invention also encompasses a method comprising, administering to a patient in need of treatment an aqueous suspension of the water-soluble polymer particles.