公开(公告)号：WO2009015048A2

公开(公告)日：2009-01-29

申请号：PCT/US2008070558

申请日：2008-07-18

Applicant: SIEMENS MEDICAL SOLUTIONS ,  MATERIA INC ,  CALIFORNIA INST OF TECHN ,  ELIZAROV ARKADIJ M ,  KOLB HARTMUTH C ,  VAN DAM R MICHAEL ,  HEATH JAMES R ,  EDGECOMBE BRIAN ,  MOTAMEDI FARSHAD ,  STEPHEN ANTHONY ,  GIARDELLO MICHAEL A

Inventor： ELIZAROV ARKADIJ M ,  KOLB HARTMUTH C ,  VAN DAM R MICHAEL ,  HEATH JAMES R ,  EDGECOMBE BRIAN ,  MOTAMEDI FARSHAD ,  STEPHEN ANTHONY ,  GIARDELLO MICHAEL A

IPC: C07B59/00 ,  B01D59/40

CPC classification number: C07B59/00

Abstract: Methods and apparatus enable radiosynthesis of radiolabeled compounds using electrochemical trapping and release. The trapping and release of radioactive isotopes all occur inside a microreactor, a vial or similar device, thus eliminating the need for azeotropic drying and several dead-end filling steps, as well as the necessity to move concentrated radioisotopes from one compartment of the chip to another. These and other features allow radioisotope enrichment to be carried out internally within a radiochemical synthesis chip, providing faster and more robust operation, as well as producing very high radiochemical labeling yields.

Abstract translation: 方法和装置能够使用电化学捕获和释放来放射性标记化合物的放射合成。 放射性同位素的捕获和释放都发生在微反应器，小瓶或类似装置内，因此不需要共沸干燥和几个死端填充步骤，以及将浓缩放射性同位素从芯片的一个室移动到 另一个。 这些和其他特征允许放射性同位素富集在放射化学合成芯片内部进行，提供更快和更强的操作，以及产生非常高的放射化学标记产率。

公开(公告)号：EP1331998A4

公开(公告)日：2006-09-06

申请号：EP01979598

申请日：2001-10-03

Applicant: CALIFORNIA INST OF TECHN

Inventor： VAN DAM R MICHAEL ,  UNGER MARC A ,  QUAKE STEPHEN R

IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  C07B61/00 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14

CPC classification number: B01J19/0046 ,  B01J2219/00355 ,  B01J2219/00398 ,  B01J2219/00418 ,  B01J2219/00427 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B82Y30/00 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention provides a chemical reaction apparatus for synthesizing an array of compounds and methods for using the same. In particular, the chemical reaction apparatus comprises a solid support base (100), a first elastic member (20) attached to the solid support base (100), and a first plurality of flow channels (104) between the solid support base and the first elastic member (20). In addition, the solid support base (100) comprises a functional group within at least a portion of the first plurality of flow channels (104) for attaching compounds thereto. Moreover, the chemical reaction apparatus of the present invention can also include a second elastic member (200) attached to the first elastic member (20). A plurality of pressure channels (304) in between the first (20) and the second (200) elastic members allows control of fluid flow within the first plurality of flow channels (104) and/or the second plurality of flow channels (108).