公开(公告)号：WO2019209377A3

公开(公告)日：2019-10-31

申请号：PCT/US2018/063486

申请日：2018-11-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ADALIAN, Dvin ,  CHEN, Samson ,  JILANI, Muhammad M. ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  SMITH, Richard

IPC: G01N27/327 ,  G01N27/416

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：WO2008115264A2

公开(公告)日：2008-09-25

申请号：PCT/US2007/078165

申请日：2007-09-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  VYAWAHARE, Saurabh ,  SITAULA, Suresh ,  ADALIAN, Dvin ,  SCHERER, Axel

Inventor： VYAWAHARE, Saurabh ,  SITAULA, Suresh ,  ADALIAN, Dvin ,  SCHERER, Axel

IPC: F16K99/00

CPC classification number: F16K99/0001 ,  C08L2201/12 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0038 ,  F16K99/004 ,  F16K99/0044 ,  F16K99/0059 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: Microfluidic valves constructed from elastomcric materials as the valve body components and employing shape memory alloy in wire form as the valve actuator. Various configurations of individual valves having both normally open and normally closed states are described. Apparatus using such valves and providing logic functionality with fluidic logic outputs are discussed. Apparatus that can be used for materials processing at the nano- or micro- scale are presented. Various forms of logical control of valve arrays are explained.

Abstract translation: 由弹性材料构成的微流体阀作为阀体部件，采用形状记忆合金作为阀门致动器。 描述具有常开和常闭状态的各个阀的各种构造。 讨论了使用这种阀并提供具有流体逻辑输出的逻辑功能的装置。 介绍了可用于纳米级或微尺度材料加工的设备。 说明阀阵列的各种形式的逻辑控制。

公开(公告)号：WO2023064908A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/078126

申请日：2022-10-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER ,  HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)

Inventor： PLETTENBURG, Oliver ,  AHLBRECHT, Christin ,  ADALIAN, Dvin ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  CHEN, Samson ,  JILANI, Muhammad Musab

IPC: G01N27/327

Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.

公开(公告)号：WO2019209377A2

公开(公告)日：2019-10-31

申请号：PCT/US2018/063486

申请日：2018-11-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： ADALIAN, Dvin ,  CHEN, Samson ,  JILANI, Muhammad M. ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  SMITH, Richard

IPC: G01N27/327

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：EP4235165A3

公开(公告)日：2023-09-27

申请号：EP23162484.2

申请日：2018-11-30

Applicant: California Institute of Technology

Inventor： ADALIAN, Dvin ,  CHEN, Samson ,  JILANI, Muhammad M. ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  SMITH, Richard

IPC: G01N27/327 ,  G01N27/416 ,  A61B5/145 ,  A61B5/1486

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：EP4235165A2

公开(公告)日：2023-08-30

申请号：EP23162484.2

申请日：2018-11-30

Applicant: California Institute of Technology

Inventor： ADALIAN, Dvin ,  CHEN, Samson ,  JILANI, Muhammad M. ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  SMITH, Richard

IPC: G01N27/327 ,  G01N27/416 ,  A61B5/145 ,  A61B5/1486

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：EP3775861A2

公开(公告)日：2021-02-17

申请号：EP18916848.7

申请日：2018-11-30

Applicant: California Institute of Technology

Inventor： ADALIAN, Dvin ,  CHEN, Samson ,  JILANI, Muhammad M. ,  SCHERER, Axel ,  MADERO, Xiomara Linnette ,  SMITH, Richard

IPC: G01N27/327 ,  G01N27/416

公开(公告)号：EP4416495A1

公开(公告)日：2024-08-21

申请号：EP22882049.4

申请日：2022-10-14

Applicant: California Institute of Technology ,  Gottfried Wilhelm Leibniz Universität Hannover ,  Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH

Inventor： PLETTENBURG, Oliver ,  AHLBRECHT, Christin ,  ADALIAN, Dvin ,  SCHERER, Axel ,  MADERO, Xiomara, Linnette ,  CHEN, Samson ,  JILANI, Muhammad, Musab

IPC: G01N27/327

CPC classification number: C12Q1/006 ,  G01N27/3271 ,  C12Q1/005 ,  A61B5/14865 ,  A61B2562/1220130101

公开(公告)号：EP3688450A1

公开(公告)日：2020-08-05

申请号：EP18860065.4

申请日：2018-09-27

Applicant: California Institute of Technology

Inventor： CHEN, Samson ,  SCHERER, Axel ,  MADERO, Xiomara L. ,  KISHORE KUMAR, Deepan ,  JILANI, Muhammad Musab ,  ADALIAN, Dvin ,  PETILLO, Peter

IPC: G01N27/327 ,  A61B5/145 ,  C12Q1/00