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公开(公告)号：WO2020146379A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012572
申请日：2020-01-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： FARHADI, Arash , HO, Gabrielle H. , SAWYER, Daniel P. , SHAPIRO, Mikhail
Abstract: Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
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公开(公告)号：WO2020146367A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012557
申请日：2020-01-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： SAWYER, Daniel P. , FARHADI, Arash , BAR-ZION, Avinoam D. , SHAPIRO, Mikhail
Abstract: The application of a step function increase in acoustic pressure during ultrasound imaging using gas vesicle contrast, along with capturing successive frames of ultrasound imaging and extracting time-series vectors for pixels of the frames, allows for improved imaging down to even the cell level. Template vectors can be used to implement signal separation of the time-series vectors to improve detection.
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公开(公告)号：EP3908656A1
公开(公告)日：2021-11-17
申请号：EP20739042.8
申请日：2020-01-07
Applicant: California Institute of Technology
Inventor： FARHADI, Arash , HO, Gabrielle H. , SAWYER, Daniel P. , SHAPIRO, Mikhail , HURT, Robert C. , DUAN, Mengtong
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