公开(公告)号：WO2003081968A1

公开(公告)日：2003-10-02

申请号：PCT/US2003/008176

申请日：2003-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  HE, Qing

Inventor： TAI, Yu-Chong ,  HE, Qing

IPC: H05K3/02

CPC classification number: B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

Abstract: A method for integrally fabricated MEMs devices with include micro or nanoparticles by providing a mixture (16) of sacrificial material (12) and a multiplicity of particles (10), disposing the mixture (16) on a substrate (14), fabricating a MEMs structure on the substrate (14) including at least part of the mixture (16), so that at least some of the mixture (16) is enclosed in the MEMs structure, removing the sacrificial material (12), and leaving at least some of the multiplicity of particles (10) substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles (10), which may be microbeads or nanobeads, are included.

Abstract translation: 一种通过提供牺牲材料（12）的混合物（16）和多个颗粒（10），将混合物（16）设置在基底（14）上的，用于整体制造的MEM装置的方法，其包括微型或纳米颗粒，制造MEM 包括至少部分混合物（16）的衬底（14）上的结构，使得混合物（16）中的至少一些被封闭在MEM结构中，去除牺牲材料（12），并且留下至少一些 基本上游离并包围在MEMs结构中的颗粒（10）的多样性。 制造MEMs结构的步骤是相当普遍的，并且被设想为包括用于产生某些类型的结构的一个或多个附加步骤，其中可以包括可以是微珠或纳米珠的颗粒（10）。

公开(公告)号：WO2006015308A3

公开(公告)日：2006-02-09

申请号：PCT/US2005/027234

申请日：2005-07-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  MISERENDINO, Scott ,  HE, Qing ,  ZHENG, Siyang

Inventor： TAI, Yu-Chong ,  MISERENDINO, Scott ,  HE, Qing ,  ZHENG, Siyang

IPC: B01L3/02

Abstract: A packaging system for microfluidics including a microfluidic modular packaging system comprising: a packaging jig comprising a body (001 ), at least two module ports (006) for placing microfluidic modules (002), at least one external fluidic port (004), and at least one internal fluidic port (005), at least two die platforms adapted to fit into the module ports (006) and move the microfluidic modules (002); at least one fluidic control die (003); at least one circuit board (010), and at least one cover (009). HPLC applications are particularly important for proteomics research and commercialization.

公开(公告)号：WO2004002878A2

公开(公告)日：2004-01-08

申请号：PCT/US2003/020074

申请日：2003-06-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  XIE, Jun ,  HE, Qing ,  LEE, Terry, Dwight

Inventor： TAI, Yu-Chong ,  XIE, Jun ,  HE, Qing ,  LEE, Terry, Dwight

IPC: B81C

CPC classification number: G01N30/6095 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/046 ,  F04B17/00 ,  F04B19/006 ,  G01N30/32 ,  G01N30/7266 ,  G01N2030/285 ,  G01N2030/326 ,  H01J49/04

Abstract: Electrochemical actuation is adopted in an integrated microfluidic chip to transfer fluid for sample preparation, separation and detection. The electrochemical actuation is capable of producing high pressure for on-chip fluidic handling. Technologies and methods are also developed to use only electrical source to control on-chip fluid handling without any external fluidic support. Applications for the devices and methods include micro scale HPLC, ESI-MS, etc.

Abstract translation: 集成微流体芯片采用电化学驱动，用于传送样品制备，分离和检测的流体。 电化学致动能够产生用于片上流体处理的高压。 还开发了技术和方法，仅使用电源来控制片上流体处理，而无需任何外部流体支持。 设备和方法的应用包括微量HPLC，ESI-MS等

公开(公告)号：WO2005018770A3

公开(公告)日：2005-03-03

申请号：PCT/US2004/026657

申请日：2004-08-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CITY OF HOPE ,  TAI, Yu-Chong ,  HE, Qing ,  XIE, Jun ,  PANG, Changlin ,  LEE, Terry, D.

Inventor： TAI, Yu-Chong ,  HE, Qing ,  XIE, Jun ,  PANG, Changlin ,  LEE, Terry, D.

IPC: B01D15/08

Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, frits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.

公开(公告)号：WO2005079944A1

公开(公告)日：2005-09-01

申请号：PCT/US2005/005219

申请日：2005-02-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  XIE, Jun ,  SHIH, Chi-Yuan ,  HE, Qing

Inventor： TAI, Yu-Chong ,  XIE, Jun ,  SHIH, Chi-Yuan ,  HE, Qing

IPC: B01D15/08

CPC classification number: G01N30/54 ,  G01N30/30 ,  G01N30/6095 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N2035/00108

Abstract: An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.

Abstract translation: 用于液相色谱的装置包括在基底上的液相色谱分离柱，其中分离柱与基底上的加热器相连。 基于芯片的温度控制液相色谱装置包括基底，热隔离区和通过热隔离区与基底热隔离的分离柱。 提供了一种包括冷却装置的基于芯片的液相色谱仪。 温度梯度液相色谱系统包括基于芯片的温度控制液相色谱装置，流体耦合和电接口。 还提供了制备方法和使用基于芯片的温度梯度液相色谱装置的方法。

公开(公告)号：EP1572576A2

公开(公告)日：2005-09-14

申请号：EP03739310.5

申请日：2003-06-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： TAI, Yu-Chong ,  XIE, Jun ,  HE, Qing ,  LEE, Terry, Dwight

IPC: B81C1/00

CPC classification number: G01N30/6095 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/046 ,  F04B17/00 ,  F04B19/006 ,  G01N30/32 ,  G01N30/7266 ,  G01N2030/285 ,  G01N2030/326 ,  H01J49/04

Abstract: Electrochemical actuation is adopted in an integrated microfluidic chip to transfer fluid for sample preparation, separation and detection. The electrochemical actuation is capable of producing high pressure for on-chip fluidic handling. Technologies and methods are also developed to use only electrical source to control on-chip fluid handling without any external fluidic support. Applications for the devices and methods include micro scale HPLC, ESI-MS, etc.

公开(公告)号：EP1485328A1

公开(公告)日：2004-12-15

申请号：EP03716653.5

申请日：2003-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： TAI, Yu-Chong ,  HE, Qing

IPC: C03C1/00

CPC classification number: B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

Abstract: A method for integrally fabricated MEMs devices with include micro or nanoparticles by providing a mixture (16) of sacrificial material (12) and a multiplicity of particles (10), disposing the mixture (16) on a substrate (14), fabricating a MEMs structure on the substrate (14) including at least part of the mixture (16), so that at least some of the mixture (16) is enclosed in the MEMs structure, removing the sacrificial material (12), and leaving at least some of the multiplicity of particles (10) substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles (10), which may be microbeads or nanobeads, are included.

公开(公告)号：EP1673152A2

公开(公告)日：2006-06-28

申请号：EP04786516.7

申请日：2004-08-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  City of Hope

Inventor： TAI, Yu-Chong ,  HE, Qing ,  XIE, Jun ,  PANG, Changlin ,  LEE, Terry, D.

IPC: B01D1/00

CPC classification number: H05K3/284 ,  G01N30/6047 ,  G01N30/6095 ,  G01N2030/645 ,  G03F1/80 ,  G01N2030/625

Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, frits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.