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公开(公告)号：WO2013116780A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024509
申请日：2013-02-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: C12Q1/68
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。
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2.发明申请METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS IN AN ARRAY 审中-公开MICROSCALE组件在阵列中的微分离，提取和/或分析的方法和设备
公开(公告)号：WO2016115457A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/013589
申请日：2016-01-15
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , CURATE BIOSCIENCES LLC
Inventor： KARTALOV, Emil, P. , LEE, Cheng-Chung , PREDKI, Paul
CPC classification number: C12N15/1093 , B01L3/502707 , B01L2300/0816 , B01L2300/0887 , C12Q1/6853 , C12Q1/686 , C12Q1/6874 , C12Q2563/179
Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation device can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation device can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation device can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the devices described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein. The micro-isolation devices can comprise a unique combination of barcodes in each microfluidics well, allowing two-dimensional mapping of genetic information.
Abstract translation: 本文提供用于微生物细胞材料的微分离的装置和方法。 所描述的微隔离装置可以包括保护感兴趣区域以防止DNA破坏照明的光掩模。 微型隔离装置还可以包括光敏材料，该感光材料在照明之后界定存取孔，随后显影感光材料。 微隔离装置还可以包括腔室微流体装置，其包括通道，其提供对感光材料中限定的孔的通路。 微隔离装置可以包括腔室微流体装置，其中光敏材料中没有限定孔，其中阀控制通过微流体装置的通道的气体或液体的流动。 还包括使用本文所述装置选择性分离细胞材料的方法，以及使用本文所述装置的细胞材料的各个感兴趣区域的生物化学分析的方法。 还包括制备用于本文所述方法的掩蔽阵列的方法。 微隔离装置可以包括每个微流体阱中的条形码的独特组合，允许遗传信息的二维映射。
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3.发明申请DEVICES AND METHODS FOR CELL LYSIS AND SAMPLE PREPARATION THROUGH CENTRIFUGATION 审中-公开通过离心进行细胞分析和样品制备的装置和方法
公开(公告)号：WO2014058868A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/063865
申请日：2013-10-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： RAJAGOPAL, Aditya , KARTALOV, Emil, P. , ALLENDORPH, Carl, J. , SCHERER, Axel , CHEN, Samson
IPC: G01N1/28 , G01N33/483 , B04B5/00
CPC classification number: C12M47/06
Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
Abstract translation: 公开了基于离心的分子分析方法和装置。 离心机装置包括离心管和元件条，以产生磁场。 施加到具有生物分子的溶液中的珠的磁剪切力允许执行不同的分析技术，例如用于PCR的裂解和样品制备。
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公开(公告)号：EP4361606A2
公开(公告)日：2024-05-01
申请号：EP24161817.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: G01N21/64
CPC classification number: C12Q1/6851 , G16B40/10 , G16B25/20 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：EP2809813B1
公开(公告)日：2018-08-08
申请号：EP13744261.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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Patent Agency Ranking
公开(公告)号：EP4361608A3
公开(公告)日：2024-07-24
申请号：EP24161841.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: G16B40/10 , G16B25/20 , C12Q1/6825 , C12Q1/6851
CPC classification number: C12Q1/6851 , G16B40/10 , G16B25/20 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：EP4361608A2
公开(公告)日：2024-05-01
申请号：EP24161841.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: G01N21/64
CPC classification number: C12Q1/6851 , G16B40/10 , G16B25/20 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：EP2809813A1
公开(公告)日：2014-12-10
申请号：EP13744261.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: C12Q1/68
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：EP4361609A3
公开(公告)日：2024-07-17
申请号：EP24161844.6
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: G16B40/10 , G16B25/20 , C12Q1/6825 , C12Q1/6851
CPC classification number: C12Q1/6851 , G16B40/10 , G16B25/20 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：EP4361606A3
公开(公告)日：2024-07-10
申请号：EP24161817.2
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: G16B25/20 , G16B40/10 , C12Q1/6825 , C12Q1/6851
CPC classification number: C12Q1/6851 , G16B40/10 , G16B25/20 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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