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公开(公告)号：WO2017218777A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037682
申请日：2017-06-15
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： RAJAGOPAL, Aditya , KARTALOV, Emil P.
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
Abstract translation: 本发明涉及通过PCR检测核酸分析物的方法。 具体而言，提供了用于检测多种核酸分析物和产生动力学特征的方法和试剂盒。 进一步提供了使用限制性引物的巢式PCR和PCR的方法和试剂盒。
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公开(公告)号：WO2013116780A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024509
申请日：2013-02-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
Inventor： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC: C12Q1/68
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。
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公开(公告)号：WO2021173736A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/019498
申请日：2021-02-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： RAJAGOPAL, Aditya
IPC: C12Q1/686
Abstract: Methods for regulating and continuously monitoring a chemical synthesis reaction using micro-objects and electro-magnetic radiation include introducing micro-objects to a reaction mixture, determining a plasm on resonance of the micro-object based on a characteristic of the micro-object, and applying electro-magnetic radiation that is wavelength- matched to the plasmon resonance of the micro-object.
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公开(公告)号：WO2021051107A1
公开(公告)日：2021-03-18
申请号：PCT/US2020/050778
申请日：2020-09-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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5.发明申请NANOPILLAR FIELD-EFFECT AND JUNCTION TRANSISTORS WITH FUNCTIONALIZED GATE AND BASE ELECTRODES 审中-公开具有功能门和基极的NANOPILLAR场效应和结晶晶体管
公开(公告)号：WO2014018286A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/050367
申请日：2013-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI US
Inventor： RAJAGOPAL, Aditya , CHANG, Chieh-Feng , PLETTENBURG, Oliver , PETRY, Stefan , SCHERER, Axel , TSCHIRHART, Charles, L.
IPC: G01N27/414 , G01N33/50 , B82B3/00
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。
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Patent Agency Ranking
公开(公告)号：WO2011022690A3
公开(公告)日：2011-02-24
申请号：PCT/US2010/046220
申请日：2010-08-20
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SCHERER, Axel , RAJAGOPAL, Aditya , KIM, Seheon , HOMYK, Andrew, P.
Inventor： SCHERER, Axel , RAJAGOPAL, Aditya , KIM, Seheon , HOMYK, Andrew, P.
IPC: H01L31/04
Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.
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7.发明申请DEVICES AND METHODS FOR NUCLEIC ACID EXTRACTION CAPTURE AND CONCENTRATION USING ELECTRIC FIELDS AND CENTRIFUGATION 审中-公开使用电场和离心的核酸提取捕获和浓度的装置和方法
公开(公告)号：WO2014074322A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/066697
申请日：2013-10-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： RAJAGOPAL, Aditya , ALLENDORPH, Carl J. , SCHERER, Axel
CPC classification number: B04B5/0414 , B01L3/50215 , B04B5/10
Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device has centrifuge tubes and elements to create electric fields. The shear forces applied to the cells inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
Abstract translation: 公开了基于离心的分子分析方法和装置。 离心机具有离心管和元件以产生电场。 用生物分子施加到溶液中的细胞的剪切力允许执行不同的分析技术，例如用于PCR的裂解和样品制备。
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8.发明申请SYSTEMS AND METHODS FOR WIRELESS TRANSDUCERS THROUGH INTEGRATED ON-CHIP ANTENNA 审中-公开通过集成片上天线的无线传感器的系统和方法
公开(公告)号：WO2014062308A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/058548
申请日：2013-09-06
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： CHANG, Chieh-feng , RAJAGOPAL, Aditya , SCHERER, Axel
CPC classification number: H02J17/00 , A61B5/0017 , A61B5/0031 , A61B18/18 , A61B2560/0219 , A61N1/08 , G06K19/0707 , G06K19/0716 , G06K19/0717 , G06K19/07775 , H01L31/042 , H02J50/10 , H02J50/30
Abstract: A system comprises an energy-harvesting unit configured to provide power to the system from electromagnetic radiation, a transducer configured to detect measureable quantities, an electronic circuit and an antenna, wherein the electronic circuit is configured to encode the measureable quantities and transmit them to the antenna, the antenna is configured to transmit the encoded measureable quantities, and wherein the energy-harvesting unit, the transducer, the electronic circuit and the antenna are monolithically integrated in the system.
Abstract translation: 一种系统包括被配置为从电磁辐射向系统提供电能的能量收集单元，被配置为检测可测量的换能器，电子电路和天线，其中该电子电路被配置为对可测量量进行编码并将其传输到 天线，天线被配置为传输编码的可测量量，并且其中能量收集单元，换能器，电子电路和天线单片地集成在系统中。
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公开(公告)号：WO2012145301A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/033914
申请日：2012-04-17
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , CHEN, Samson , RAJAGOPAL, Aditya , SCHERER, Axel
Inventor： CHEN, Samson , RAJAGOPAL, Aditya , SCHERER, Axel
CPC classification number: H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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公开(公告)号：WO2012045016A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/054366
申请日：2011-09-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , WALAVALKAR, Sameer , RAJAGOPAL, Aditya , SCHERER, Axel , TOMBRELLO, Thomas, A.
Inventor： WALAVALKAR, Sameer , RAJAGOPAL, Aditya , SCHERER, Axel , TOMBRELLO, Thomas, A.
CPC classification number: B01D67/0062 , B01D61/027 , B01D61/145 , B01D69/06 , B01D71/027 , B07B1/00 , B07B1/4618 , B81C1/00031 , B81C1/00111 , B81C1/00119 , B81C1/00158 , B81C1/00531 , B81C1/00539 , B82Y40/00 , G01N33/48721 , H01L21/0331
Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.
Abstract translation: 本文公开了用于分离和分选纳米粒子的方法和装置。 所需尺寸的纳米孔可以在二氧化硅膜中形成并用作过滤器以分离纳米粒子。 本文还提供了用于利用具有各种尺寸的纳米孔的多个过滤器对纳米颗粒进行分选的装置。
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