公开(公告)号：WO2017218777A1

公开(公告)日：2017-12-21

申请号：PCT/US2017/037682

申请日：2017-06-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： RAJAGOPAL, Aditya ,  KARTALOV, Emil P.

IPC: C12Q1/68 ,  C07H21/04

Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.

Abstract translation: 本发明涉及通过PCR检测核酸分析物的方法。 具体而言，提供了用于检测多种核酸分析物和产生动力学特征的方法和试剂盒。 进一步提供了使用限制性引物的巢式PCR和PCR的方法和试剂盒。

公开(公告)号：WO2020146106A1

公开(公告)日：2020-07-16

申请号：PCT/US2019/067170

申请日：2019-12-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： KARTALOV, Emil P. ,  SCHERER, Axel

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/00 ,  G01N27/22

Abstract: Methods to build implantable micro-sensors used to detect tissue-dissolved inert gas and to detect microbubble formation to avoid Caisson disease are described. The disclosed methods and devices are based on measuring physical changes in hydrophobic liquids after absorbing an inert gas such as nitrogen. The teachings of the disclosure help improve safety and efficiency of diving operations.

公开(公告)号：WO2013086103A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/068123

申请日：2012-12-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI AVENTIS

Inventor： SCHERER, Axel ,  BROUARD, Remi ,  KARTALOV, Emil P. ,  HUANG, Jingqing

IPC: A61B5/1459 ,  A61B5/157

CPC classification number: A61B5/1459 ,  A61B3/10 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/14507 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1491 ,  A61B5/20 ,  A61B5/418 ,  A61B5/42 ,  A61B5/4337 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/6866 ,  A61B5/7278 ,  A61B2560/0219 ,  A61B2560/0233

Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.

Abstract translation: 根据本公开的可植入诊断装置包括可以以各种方式实现的探针组件。 一些示例性实现包括：位于其内的针，其位于生物传感器芯片（针可插入人体中）; 包含生物传感器芯片的紧凑型封装（被配置用于放置在导管内的紧凑封装）; 或被配置为插入静脉中的硅基生物传感器封装。

公开(公告)号：EP3472354A1

公开(公告)日：2019-04-24

申请号：EP17814096.8

申请日：2017-06-15

Applicant: California Institute of Technology

Inventor： RAJAGOPAL, Aditya ,  KARTALOV, Emil P.

IPC: C12Q1/68 ,  C07H21/04