公开(公告)号：WO2019204506A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/027960

申请日：2019-04-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： MARESCA, David ,  SAWYER, Daniel P. ,  SHAPIRO, Mikhail

IPC: A61B8/13 ,  A61B8/00

Abstract: Certain aspects pertain to a cross-amplitude modulation (xAM) ultrasound transducer system that include one or more transducers, and first and second subapertures of transducer elements of the one or more transducers. The first subaperture configured to transmit a first ultrasound plane wave when excited. The second subaperture configured to transmit a second ultrasound plane wave when excited. The second ultrasound plane wave is noncollinear to the first ultrasound plane wave and axisymmetric to the first ultrasound plane wave about a bisector. The first and second subapertures are configured to transmit an xAM ultrasound pulse sequence by transmitting the first ultrasound plane wave, transmitting the second ultrasound plane wave, and simultaneously transmitting both first and second ultrasound plane waves. The first and second ultrasound plane wave are configured to generate an acoustic pressure that is above a threshold along the bisector.

公开(公告)号：WO2021231609A1

公开(公告)日：2021-11-18

申请号：PCT/US2021/032041

申请日：2021-05-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  TANTER, Mickael ,  DEMENE, Charlie

Inventor： NORMAN, Sumner L ,  MARESCA, David ,  CHRISTOPOULOS, Vasileios ,  SHAPIRO, Mikhail ,  ANDERSEN, Richard A

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/06 ,  A61F2/70 ,  A61F2002/704 ,  A61F4/00 ,  A61N1/08 ,  G06N20/00 ,  G16H30/40

Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

公开(公告)号：WO2020198728A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/025608

申请日：2020-03-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： BAR-ZION, Avinoam D. ,  NOURMAHNAD, Atousa ,  MARESCA, David ,  SHAPIRO, Mikhail

IPC: A61K49/22 ,  A61K49/18

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.