公开(公告)号：WO2021041934A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048572

申请日：2020-08-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： LAKSHMANAN, Anupama ,  SHAPIRO, Mikhail ,  NETY, Suchita P. ,  JIN, Zhiyang

IPC: C07K14/195 ,  G01N29/06 ,  G01N29/04

Abstract: Provided herein are engineerd protease sensitive gas vesicles and related engineered protease genetically GvpCconstructs, vectors, gas vesicles gene clusters, genetic circuits, cells, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging technique, to detect and report protease activity and related biological events in an imaging target site.