公开(公告)号：US11149265B2

公开(公告)日：2021-10-19

申请号：US16130810

申请日：2018-09-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem Ismagilov ,  Erik Jue ,  Daan Witters

IPC: B01L3/00 ,  B01L7/00 ,  G01N21/64 ,  C12N15/10 ,  C12Q1/6806

Abstract: A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

公开(公告)号：US11795448B2

公开(公告)日：2023-10-24

申请号：US17473832

申请日：2021-09-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem Ismagilov ,  Erik Jue ,  Daan Witters

IPC: C12N15/10 ,  B01L3/00 ,  B01L7/00 ,  G01N21/64 ,  C12Q1/6806

CPC classification number: C12N15/1003 ,  B01L3/508 ,  B01L3/50851 ,  B01L3/502753 ,  B01L7/52 ,  C12N15/1006 ,  C12N15/1013 ,  C12Q1/6806 ,  G01N21/6428 ,  G01N21/6456 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2300/04 ,  B01L2300/069 ,  B01L2300/0672 ,  B01L2300/18 ,  B01L2400/0605

Abstract: A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

公开(公告)号：US11753635B2

公开(公告)日：2023-09-12

申请号：US17511235

申请日：2021-10-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem Ismagilov ,  Erik Jue ,  Daan Witters

IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/6806 ,  B01L7/00 ,  G01N21/64

CPC classification number: C12N15/1003 ,  B01L3/508 ,  B01L3/50851 ,  B01L3/502753 ,  B01L7/52 ,  C12N15/1006 ,  C12N15/1013 ,  C12Q1/6806 ,  G01N21/6428 ,  G01N21/6456 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2300/04 ,  B01L2300/069 ,  B01L2300/0672 ,  B01L2300/18 ,  B01L2400/0605

Abstract: Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid together with a target compound having a water solubility equal to or greater than 0.01 mg per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes.

公开(公告)号：US11174477B2

公开(公告)日：2021-11-16

申请号：US16132235

申请日：2018-09-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem Ismagilov ,  Erik Jue ,  Daan Witters

IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/6806 ,  B01L7/00 ,  G01N21/64

Abstract: Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid together with a target compound having a water solubility equal to or greater than 0.01 mg per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes.