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公开(公告)号：JPH04344465A
公开(公告)日：1992-12-01
申请号：JP14517091
申请日：1991-05-22
Applicant: CANON KK
Inventor： TANAKA KAZUSANE , OKAMOTO HISASHI , MIYAZAKI TAKESHI , SUGANO TSUNEHIRO
IPC: G01N33/543
Abstract: PURPOSE:To prevent prozone phenomenon so as to enable stable and accurate measurement by reacting a complex with a second reagent while effecting physical action so that the degree of monodispersion of the complex is more than a specific value. CONSTITUTION:A first reagent, which is formed when a first material immunologically active to a material for measurement in a sample is bonded to the surface of solid particulates, is reacted with the sample in a liquid medium so as to form a complex 1 of the first reagent and the material for measurement and then a second reagent, which is formed when a second material immunologically active to the material for measurement and different from the first reagent is labeled in advance, is added to the complex 1 to generate a complex 2 and the amount by which the complex 2 is labeled is measured whereby the quantity of the material for measurement contained in the sample is determined. In this case, the complex 2 is reacted with the second reagent in such a manner that the degree X(%) of monodispersion of the complex 1, which is defined by the formula X=n/SX100 wherein n represents the number of complexes 1 which are monomers and S the total number of particulates, is more than 90. Prozone phenomenon is thereby prevented and stable and accurate measurement is made possible.
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公开(公告)号：JPH02247233A
公开(公告)日：1990-10-03
申请号：JP6736589
申请日：1989-03-18
Applicant: CANON KK
Inventor： OYAMA JUNJI , SUGANO TSUNEHIRO , TOMITA YASUKO , SAKURANAGA MASANORI
IPC: G01J1/00 , B01D69/00 , B01D71/00 , C07K14/00 , C07K14/195 , C07K14/41 , C08J5/18 , G01N27/327 , H01L49/00
Abstract: PURPOSE:To obtain the subject transmission membrane exhibiting selective ion-transmittance by light irradiation, having expanded active wavelength range and useful in an optical information processing industry by supporting a plurality of substance groups having different sensitive wavelength ranges on a lipid membrane. CONSTITUTION:The objective transmission membrane contains (A) two or more kinds of substance groups having different sensitive wavelength ranges and (B) an ionophore in a lipid membrane. Preferably, the component A is a photoreceptive protein or its derivative, especially bacteriorhodopsin or halorhodopsin and the component B is oligopeptide, etc. Furthermore, the component is preferably held in the lipid membrane in an oriented state to uniformize the ion transmission direction.
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公开(公告)号：JPH0263548A
公开(公告)日：1990-03-02
申请号：JP21592388
申请日：1988-08-29
Applicant: CANON KK
Inventor： YAMAMOTO NOBUKO , KISHI HIROYOSHI , KATO KINYA , SUGANO TSUNEHIRO , OYAMA JUNJI , IWASHITA HARUMI , SAKURANAGA MASANORI
Abstract: PURPOSE:To restrict orientation of protein for the inside and outside of membrane of vesicles by forming a layer of molecules contg. a protein on an interface between gas and liquid of a liquid suspension of membrane vesicles, and introducing the protein in the layer of the molecules into the membrane vesicles contacting with the layer of the molecules by setting a surface pressure of the layer of the molecules at a high pressure. CONSTITUTION:A layer 10 of molecules contg. a protein is formed on an interface between gas and liquid of a liquid suspension of membrane vesicles comprising a liposome consisting singly of a lipid or a proteoliposome contg. a protein. Then, the protein in the layer of the molecules is introduced into the membrane vesicles contacting with the layer of molecules by setting the surface pressure of the layer of molecules at a high pressure, for example, by moving a separating plate 20. Thus, the orientation of protein for the inside and outside of the membrane of the vesicules can be controlled in a stage of forming a proteoliposome by introducing a protein into a liposome.
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公开(公告)号：JP2002017687A
公开(公告)日：2002-01-22
申请号：JP2000206415
申请日：2000-07-07
Applicant: CANON KK
Inventor： NOMURA OSAMU , UEI TAKASHI , KUMOMI HIDEYA , SUGANO TSUNEHIRO
IPC: A61B5/00 , A61B5/0245 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/08
Abstract: PROBLEM TO BE SOLVED: To enable to obtain quantitative data of an organism at high speed. SOLUTION: For time-series biological signals such as electroencephalogram, pulse wave, electrocariogram, electromyogram, expired gas or the like, a band which partly contains a high frequency band as a biological signal is extracted, a chaos characteristic is estimated by chaos analysis of calculating either a Lyapunov exponent or a correlation dimension, and emotional information of an organism is evaluated by the numerical information from the result.
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公开(公告)号：JP2002017686A
公开(公告)日：2002-01-22
申请号：JP2000206414
申请日：2000-07-07
Applicant: CANON KK
Inventor： NOMURA OSAMU , UEI TAKASHI , KUMOMI HIDEYA , SUGANO TSUNEHIRO , TOKUDA RYUJI
IPC: A61B5/00 , A61B5/0245 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/08
Abstract: PROBLEM TO BE SOLVED: To enable to obtain quantitative data of an organism at high speed. SOLUTION: A band, partly containing high frequency band five or more times basic rhythms of time-series biological signals such as electroencephalogram, pulse wave, electrocardiogram, electromyogram, expired gas or the like as a biological signal is extracted. Then, mathematical processing is performed by chaos analysis of calculating either a Lyapunov exponent or a correlation dimension. Emotional information of an organism is evaluated by the numerical information from the result.
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Patent Agency Ranking
公开(公告)号：JP2000229279A
公开(公告)日：2000-08-22
申请号：JP3153099
申请日：1999-02-09
Applicant: CANON KK
Inventor： SAKURANAGA MASANORI , SUGANO TSUNEHIRO , TANAKA KAZUSANE
Abstract: PROBLEM TO BE SOLVED: To enable efficient restoration of polluted soil, before forcibly pouring microorganisms into soil, by pouring a member for lowering a water permeability factor into soil in the upper or lower part of a pouring object area. SOLUTION: A pouring means consisting of a pouring material tank 1, a pouring pump 2, a flowmeter 3, a pouring pipe 4 having a pouring port 6, a packer 5 for setting the pouring depth, and the like, is used to appropriately pour decomposition microorganisms and a nutrient necessary for propagation/ maintaining activity thereof, an inducer, and oxygen and other chemical substances into a restoration area 9 of polluted soil. That is to say, after a water permeability factor in the upper or lower part of a soil layer is increased, by pouring microorganisms and a nutrient necessary for maintaining the decomposition activity thereof, and the like, restoration of soil is efficiently performed. When an injection material is thus poured into soil whose upper and lower parts have undergone water impermeability treatment, total poured volume, pouring time, pouring pressure, or poured flow rate, or the like, can be adjusted to pour microorganisms, and the like, into a limited area.
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公开(公告)号：JPH03137932A
公开(公告)日：1991-06-12
申请号：JP20393689
申请日：1989-08-08
Applicant: CANON KK
Inventor： SUGANO TSUNEHIRO , TOMITA YASUKO , OYAMA JUNJI , SAKURANAGA MASANORI , KISHI HIROYOSHI , YAMAMOTO NOBUKO , KATO KINYA , IWASHITA HARUMI
Abstract: PURPOSE:To limit the directionality of protein with respect to the inside and outside of a vesicular membrane by incorporating membrane protein modified by a carrier having a predetermined volume and shape in a liposome to form a proteoliposome. CONSTITUTION:The specific region of the hydrophilic side chain of membrane protein 2 is modified by a carrier to be immobilized. Subsequently, a dispersion of a liposome 3 is mixed with the membrane protein 2 held to the carrier to incorporate the membrane protein 2 in the liposome and, thereafter, the membrane protein 2 is dissociated from the carrier 1 to form a proteoliposome 4. As the aforementioned liposome, any one capable of taking a bimolecular membrane lamella structure may be used and there are various phospholipids, glycolipids and neutral lipids. As an embodiment of a method for bonding and dissociating the specific region of the hydrophilic side chain of membrane protein, a chromatography technique of protein can be applied.
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公开(公告)号：JP2002357515A
公开(公告)日：2002-12-13
申请号：JP2001164773
申请日：2001-05-31
Applicant: CANON KK
Inventor： SUGANO TSUNEHIRO , MITSUMURA SATOSHI
Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus for detection, where living-body volatile components discharged from a living-body to the outside of the living- body, the so-called 'odorous' substance, especially an odorous material carrying information related to the physiological function, in the inside of the living-body or related to a communication between individuals, can be detected by properly combining general-purpose devices used in an ordinary clinical inspection and the odorous material can be detected quantitatively and with high accuracy for each individual. SOLUTION: Instead of the living-body volatile component actually discharged from an individual, a living-body sample which is sampled directly from the individual and which contains a precursor for the living-body volatile components, e.g. a body fluid is used, a means which separates the precursor into the living-body volatile component as a target and its carrier, e.g. an enzyme or the like is made to act, the separated living-body volatile component is detected, and the amount of the living-body volatile components which are actually discharged from the individual is estimated with high accuracy on the basis of the detected result.
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公开(公告)号：JPH0363300A
公开(公告)日：1991-03-19
申请号：JP19705789
申请日：1989-07-29
Applicant: CANON KK
Inventor： SUGANO TSUNEHIRO , TOMITA YASUKO , OYAMA JUNJI , SAKURANAGA MASANORI
IPC: A61K9/127 , B01J13/02 , B01J13/04 , C07K14/00 , C07K14/195 , C07K14/41 , C07K14/705 , C07K17/12
Abstract: PURPOSE:To form the subject liposome controllable of orientation of membrane protein recombined in macroproteoliposome by modifying a specific position in membrane protein to carrier, subjecting salt solution with membrane lipid to freezing and thawing and dialyzing. CONSTITUTION:A specific position in membrane protein is modified to a carrier and a salt solution containing the said membrane protein and membrane lipid is prepared, then the said salt solution is subjected to freezing and thawing thus dialyzed to a solution of salts having an osmotic pressure lower than the said salt solution to afford the objective liposome. Besides, further the membrane protein is preferably dissociated from the carrier after dialysis. Furthermore, preferably, shape of the said carrier is spherical and the size is equivalent or larger than the diameter of the formed liposome.
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公开(公告)号：JPH02228379A
公开(公告)日：1990-09-11
申请号：JP4855089
申请日：1989-03-02
Applicant: CANON KK
Inventor： TOMITA YASUKO , SHIROTA KATSUHIRO , SUGANO TSUNEHIRO , OYAMA JUNJI , SAKURANAGA MASANORI
IPC: C09D11/00 , C09D11/02 , C09D11/033 , C09D11/328 , C09D11/38
Abstract: PURPOSE:To prepare a recording liquid having an excellent long-storage stability and giving a picture image with an excellent resistance to ozone and change in hue by compounding liposome contg. an antioxidant into a recording liquid contg. a recording material and a liq. medium. CONSTITUTION:Liposome contg. an antioxidant is compounded into a recording liquid contg. a recording material which is a component for forming a recording image and a liq. medium in which said recording material is dissolved or dispersed. Examples of said antioxidant are phenol derivs., erythorbic acid deriv., and ascorbic acid derivs.; pref. amt. of said antioxidant compounded is usually 0.1-10wt.% based on the total of the recording liquid. A pref. recording material is a water-soluble dye, while a pref. liq. medium is water and/or an org. solvent.
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