公开(公告)号：US20190154603A1

公开(公告)日：2019-05-23

申请号：US16254446

申请日：2019-01-22

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Michael Suster ,  Pedram Mohseni ,  Debnath Maji ,  Umut Gurkan

IPC: G01N27/02 ,  G01N27/22 ,  G01N33/49

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine an indication of platelet count based on the computed dielectric permittivity values over at least a portion of the time interval.

公开(公告)号：US20190029555A1

公开(公告)日：2019-01-31

申请号：US16070126

申请日：2017-01-17

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Michael Suster ,  Michael Mohseni ,  Debnath Maji ,  Evi Stavrou ,  Umut Gurkan

IPC: A61B5/05 ,  A61B5/145 ,  G01N33/49 ,  G01N27/02 ,  G01N27/08 ,  G01N27/22

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.

公开(公告)号：US11058316B2

公开(公告)日：2021-07-13

申请号：US16870565

申请日：2020-05-08

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Michael Suster ,  Pedram Mohseni ,  Debnath Maji ,  Evi Stavrou ,  Umut Gurkan

IPC: G01N27/02 ,  A61B5/05 ,  A61B5/145 ,  G01N27/08 ,  G01N27/22 ,  G01N33/49

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.

公开(公告)号：US10674931B2

公开(公告)日：2020-06-09

申请号：US16070126

申请日：2017-01-17

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Michael Suster ,  Pedram Mohseni ,  Debnath Maji ,  Evi Stavrou ,  Umut Gurkan

IPC: A61B5/05 ,  A61B5/145 ,  G01N27/02 ,  G01N27/08 ,  G01N27/22 ,  G01N33/49

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.

公开(公告)号：US11408844B2

公开(公告)日：2022-08-09

申请号：US16837704

申请日：2020-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF PITTSBURGH

Inventor： Michael Suster ,  Pedram Mohseni ,  Anirban Sen Gupta ,  Matthew David Neal ,  Ujjal Didar Singh Sekhon ,  Sanjay Pitamber Ahuja ,  Sina Pourang ,  Debnath Maji

IPC: G01N27/22 ,  G01N27/02 ,  G01N33/49

Abstract: As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.

公开(公告)号：US11175252B2

公开(公告)日：2021-11-16

申请号：US16254446

申请日：2019-01-22

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Michael Suster ,  Pedram Mohseni ,  Debnath Maji ,  Umut Gurkan

IPC: G01N27/02 ,  G01N27/22 ,  G01N33/49 ,  A61B5/0507 ,  A61B5/145 ,  A61B5/0537 ,  G01N27/08 ,  A61B5/05

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine an indication of platelet count based on the computed dielectric permittivity values over at least a portion of the time interval.

公开(公告)号：US20200319128A1

公开(公告)日：2020-10-08

申请号：US16837704

申请日：2020-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF PITTSBURGH

Inventor： Michael Suster ,  Pedram Mohseni ,  Anirban Sen Gupta ,  Matthew David Neal ,  Ujjal Didar Singh Sekhon ,  Sanjay Pitamber Ahuja ,  Sina Pourang ,  Debnath Maji

IPC: G01N27/22 ,  G01N33/49 ,  G01N27/02

Abstract: As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.