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公开(公告)号：US12072310B2
公开(公告)日：2024-08-27
申请号：US18236059
申请日：2023-08-21
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Lalitha Nayak , Michael Suster , Sina Pourang
CPC classification number: G01N27/221 , B01L3/502715 , B01L2200/10 , B01L2300/023 , B01L2300/0663
Abstract: As one example, an apparatus includes a dielectric microsensor having a microfluidic chamber that includes a capacitive sensing structure. The microfluidic chamber is adapted to receive a volume of a blood sample, and a bioactive agent is adapted to interact with the blood sample, as a sample under test (SUT), within the microfluidic chamber. A transmitter can provide an input radio frequency (RF) signal to the dielectric microsensor, and a receiver can receive an output RF signal from the dielectric microsensor. A computing device is configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval in which the dielectric permittivity values are representative of the bioactive agent interacting with the blood sample over the time interval. The computing device is further configured to provide a readout representative of hemostatic dysfunction for the blood sample based on the dielectric permittivity values.
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公开(公告)号：US20190029555A1
公开(公告)日：2019-01-31
申请号：US16070126
申请日：2017-01-17
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Michael Suster , Michael Mohseni , Debnath Maji , Evi Stavrou , Umut Gurkan
Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.
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公开(公告)号：US20250153167A1
公开(公告)日：2025-05-15
申请号：US18942926
申请日：2024-11-11
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Anirban Sen Gupta , Dante Disharoon , Changyong Cao , Michael Suster , Emily Song
IPC: B01L3/00
Abstract: As one example, methods and systems are provided for aerosol jet printing one or more bioactive agents on a substrate to functionalize the substrate. This disclosure also relates to the resulting functionalized substrates as well as to sensing devices and systems that include such functionalized substrates.
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公开(公告)号：US20190154603A1
公开(公告)日：2019-05-23
申请号：US16254446
申请日：2019-01-22
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Michael Suster , Pedram Mohseni , Debnath Maji , Umut Gurkan
Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine an indication of platelet count based on the computed dielectric permittivity values over at least a portion of the time interval.
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公开(公告)号：US20240110884A1
公开(公告)日：2024-04-04
申请号：US18236059
申请日：2023-08-21
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Lalitha Nayak , Michael Suster , Sina Pourang
CPC classification number: G01N27/221 , B01L3/502715 , B01L2200/10 , B01L2300/023 , B01L2300/0663
Abstract: As one example, an apparatus includes a dielectric microsensor having a microfluidic chamber that includes a capacitive sensing structure. The microfluidic chamber is adapted to receive a volume of a blood sample, and a bioactive agent is adapted to interact with the blood sample, as a sample under test (SUT), within the microfluidic chamber. A transmitter can provide an input radio frequency (RF) signal to the dielectric microsensor, and a receiver can receive an output RF signal from the dielectric microsensor. A computing device is configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval in which the dielectric permittivity values are representative of the bioactive agent interacting with the blood sample over the time interval. The computing device is further configured to provide a readout representative of hemostatic dysfunction for the blood sample based on the dielectric permittivity values.
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Patent Agency Ranking
公开(公告)号：US20220326170A1
公开(公告)日：2022-10-13
申请号：US17852828
申请日：2022-06-29
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Lalitha Nayak , Michael Suster , Sina Pourang
Abstract: As one example, an apparatus includes a dielectric microsensor having a microfluidic chamber that includes a capacitive sensing structure. The microfluidic chamber is adapted to receive a volume of a blood sample, and a bioactive agent is adapted to interact with the blood sample, as a sample under test (SUT), within the microfluidic chamber. A transmitter can provide an input radio frequency (RF) signal to the dielectric microsensor, and a receiver can receive an output RF signal from the dielectric microsensor. A computing device is configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval in which the dielectric permittivity values are representative of the bioactive agent interacting with the blood sample over the time interval. The computing device is further configured to provide a readout representative of hemostatic dysfunction for the blood sample based on the dielectric permittivity values.
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公开(公告)号：US11058316B2
公开(公告)日：2021-07-13
申请号：US16870565
申请日：2020-05-08
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Michael Suster , Pedram Mohseni , Debnath Maji , Evi Stavrou , Umut Gurkan
Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.
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公开(公告)号：US10674931B2
公开(公告)日：2020-06-09
申请号：US16070126
申请日：2017-01-17
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Michael Suster , Pedram Mohseni , Debnath Maji , Evi Stavrou , Umut Gurkan
Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.
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公开(公告)号：US11774388B2
公开(公告)日：2023-10-03
申请号：US17852828
申请日：2022-06-29
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Lalitha Nayak , Michael Suster , Sina Pourang
CPC classification number: G01N27/221 , B01L3/502715 , B01L2200/10 , B01L2300/023 , B01L2300/0663
Abstract: As one example, an apparatus includes a dielectric microsensor having a microfluidic chamber that includes a capacitive sensing structure. The microfluidic chamber is adapted to receive a volume of a blood sample, and a bioactive agent is adapted to interact with the blood sample, as a sample under test (SUT), within the microfluidic chamber. A transmitter can provide an input radio frequency (RF) signal to the dielectric microsensor, and a receiver can receive an output RF signal from the dielectric microsensor. A computing device is configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval in which the dielectric permittivity values are representative of the bioactive agent interacting with the blood sample over the time interval. The computing device is further configured to provide a readout representative of hemostatic dysfunction for the blood sample based on the dielectric permittivity values.
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公开(公告)号：US11408844B2
公开(公告)日：2022-08-09
申请号：US16837704
申请日：2020-04-01
Applicant: CASE WESTERN RESERVE UNIVERSITY , UNIVERSITY OF PITTSBURGH
Inventor： Michael Suster , Pedram Mohseni , Anirban Sen Gupta , Matthew David Neal , Ujjal Didar Singh Sekhon , Sanjay Pitamber Ahuja , Sina Pourang , Debnath Maji
Abstract: As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.
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