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    METHOD FOR TREATING DISEASES MEDIATED BY CELLULAR PROLIFERATION IN RESPONSE TO PDGF, EGF, FGF AND VEGF
    6.
    发明专利
    METHOD FOR TREATING DISEASES MEDIATED BY CELLULAR PROLIFERATION IN RESPONSE TO PDGF, EGF, FGF AND VEGF 未知

    公开(公告)号：CA2192470A1

    公开(公告)日：1995-07-20

    申请号：CA2192470

    申请日：1995-01-13

    Applicant: CELL THERAPEUTICS INC

    Inventor： BROWN PAUL A ,  BURSTEN STUART L ,  RICE GLENN C ,  SINGER JACK W

    IPC: A61K31/00 ,  A61K31/52 ,  A61K31/522 ,  A61K31/135 ,  A61K31/16 ,  A61K31/40 ,  A61K31/44 ,  A61K31/505 ,  A61K31/535 ,  A61K45/00

    Abstract: There is disclosed a method for: (1) inhibiting new blood vessel formation that is useful for treating or preventing progression of diabetic retinopathy, cavernous haemangiomas, Kaposi's sarcoma, tumors composed of endothelial-like cells, and growth of solid tumors by preventing their development of a new blood supply; (2) suppressing development of kidney diseases due to cytokine induced proliferation of mesangial cells and/or glomerular epithelial cells that is useful for treating or preventing progression of diabetic glomerulosclerosis and other glomerulonephritides of various types and etiologies; (3) preventing joint destruction accompanying rheumatoid arthritis due to proliferation of synovial cells; (4) suppressing manifestations of psoriasis due to proliferation of keratinocytes and accumulation of inflammatory cells; (5) suppressing accelerated atherogenesis involved in restenosis of coronary vessels or other arterial vessels following angioplasty; (6) suppressing artherogenesis, coronary artery disease and other vasculopathies due to atherogenesis; and (7) suppressing tumor growth via paracrine or autocrine mediated responses to PDGF, FGF, EGF or VEGF this is useful for treating or preventing progression of tumors such as breast cancer stimulated through overexpression of her-2-neu receptor, wherein the inventive method comprises administering a compound that inhibits signal transduction through cellular accumulation of phosphatidic acid (PA) having predominantly linoleate and a C22 alkyl or alkenyl in the sn-2 position or a vinyl ether alkenyl group in the sn-1 position.

    METHOD FOR TREATING DISEASES MEDIATED BY CELLULAR PROLIFERATION IN RESPONSE TO PDGF, EGF, FGF AND VEGF
    9.
    发明公开
    METHOD FOR TREATING DISEASES MEDIATED BY CELLULAR PROLIFERATION IN RESPONSE TO PDGF, EGF, FGF AND VEGF 失效
    造成细胞增殖响应PDGF，EGF，FGF，VEGF疾病的处理方法及聘为

    公开(公告)号：EP0739203A4

    公开(公告)日：2000-12-20

    申请号：EP95910088

    申请日：1995-01-13

    Applicant: CELL THERAPEUTICS INC

    Inventor： BROWN PAUL A ,  BURSTEN STUART L ,  RICE GLENN C ,  SINGER JACK W

    IPC: A61K31/00 ,  A61K31/52 ,  A61K31/522 ,  A61K31/44 ,  A61K31/135 ,  A61K31/435 ,  A61K31/505 ,  A61K31/66

    CPC classification number: A61K31/52 ,  A61K31/00 ,  A61K31/522

    Abstract: There is disclosed a method for: (1) inhibiting new blood vessel formation that is useful for treating or preventing progression of diabetic retinopathy, cavernous haemangiomas, Kaposi's sarcoma, tumors composed of endothelial-like cells, and growth of solid tumors by preventing their development of a new blood supply; (2) suppressing development of kidney diseases due to cytokine induced proliferation of mesangial cells and/or glomerular epithelial cells that is useful for treating or preventing progression of diabetic glomerulosclerosis and other glomerulonephritides of various types and etiologies; (3) preventing joint destruction accompanying rheumatoid arthritis due to proliferation of synovial cells; (4) suppressing manifestations of psoriasis due to proliferation of keratinocytes and accumulation of inflammatory cells; (5) suppressing accelerated atherogenesis involved in restenosis of coronary vessels or other arterial vessels following angioplasty; (6) suppressing artherogenesis, coronary artery disease and other vasculopathies due to atherogenesis; and (7) suppressing tumor growth via paracrine or autocrine mediated responses to PDGF, FGF, EGF or VEGF this is useful for treating or preventing progression of tumors such as breast cancer stimulated through overexpression of her-2-neu receptor, wherein the inventive method comprises administering a compound that inhibits signal transduction through cellular accumulation of phosphatidic acid (PA) having predominantly linoleate and a C22 alkyl or alkenyl in the sn-2 position or a vinyl ether alkenyl group in the sn-1 position.

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