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    Method of inhibiting interleukin-12 signaling
    2.
    发明专利
    Method of inhibiting interleukin-12 signaling 未知

    公开(公告)号：AU2098799A

    公开(公告)日：1999-08-02

    申请号：AU2098799

    申请日：1998-12-30

    Applicant: CELL THERAPEUTICS INC

    Inventor： KLAUS STEPHEN J ,  KLEIN PETER J ,  KUMAR ANIL M

    IPC: A61K31/00 ,  C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/52

    Abstract: Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 ("IL-12") intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N,N(R3) and S. Each R1, R2 and R3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(1-20)tetraminoalkyl, C(5-15)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1-11)alkoxyalkyl, and C(1-20)dialkoxyalkyl.

    9.
    发明专利
    未知

    公开(公告)号：NO20021701L

    公开(公告)日：2002-05-23

    申请号：NO20021701

    申请日：2002-04-11

    Applicant: CELL THERAPEUTICS INC

    Inventor： KUMAR ANIL M ,  KLEIN PETER J ,  BHATT RAMA ,  VAWTER EDWARD

    IPC: A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K47/42 ,  A61K47/48 ,  A61P35/00 ,  C07D305/14

    Abstract: The present invention relates to conjugates comprising a polyglutamic acid polymer covalently bonded to a camptothecin molecule selected from the group consisting of 20(S)(+)-camptothecin, 9-aminocamptothecin, 9-nitrocamptothecin, 7-ethyl-10-hydroxycamptothecin, 9-dimethyl-aminomethyl-10-hydroxycamptothecin and 7-methylpiperizinomethyl-10,11-ethylenedioxy-camptothecin. The present invention also relates to such compounds as medicaments, in particular for the treatment of cancer.

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