公开(公告)号：WO9834601A2

公开(公告)日：1998-08-13

申请号：PCT/US9802622

申请日：1998-02-10

Applicant: CELL THERAPEUTICS INC

Inventor： LEUNG DAVID W ,  UNDERINER GAIL E ,  SINGER JACK W

IPC: A61K31/4035 ,  A61K31/445 ,  A61K31/472 ,  A61K31/513 ,  A61K31/522 ,  C12N15/48 ,  A61K31/00

CPC classification number: A61K31/522 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/472 ,  A61K31/513

Abstract: There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an effective amount of a compound that inhibits cellular signaling through a specific phospholipid-based cellular signaling and signal amplification pathway. The invention further provides a method for preventing or delaying clinical symptoms of a group of viral diseases wherein the viral disease is mediated by host cell viral replication. The invention provides an advantage by attacking host cellular signaling mechanisms to prevent the development of drug resistance from rapidly mutating viruses.

Abstract translation: 公开了通过施用有效量的抑制细胞信号传导的化合物通过特定的基于磷脂的细胞信号传导和信号扩增来预防或延迟人类免疫缺陷病毒（HIV）血清阳性人类中的获得性免疫缺陷综合征（AIDS）的发生的方法 途径。 本发明还提供了一种用于预防或延缓一组病毒性疾病的临床症状的方法，其中所述病毒性疾病由宿主细胞病毒复制介导。 本发明通过攻击宿主细胞信号传导机制来提供一个优点，以防止快速突变病毒对耐药性的发展。

公开(公告)号：DK0623133T3

公开(公告)日：2004-12-20

申请号：DK94900587

申请日：1993-11-09

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  UNDERINER GAIL E ,  LEIGH ALISTAIR J

IPC: C07D251/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  C07D213/64 ,  C07D239/54 ,  C07D239/62 ,  C07D239/72 ,  C07D471/02 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D473/30

Abstract: Compounds and pharmaceutical compositions thereof comprise the general formula: (R)j - (core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein j is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring structure, R may be selected from the group consisting of a hydrogen, halogen atom, hydroxyl, amino, substituted or unsubstituted benzyl, alkyl (C1-6) or alkenyl (C2-6) group, and at least one R has the general formula I: wherein n is an integer from four to eighteen; each R'1 and R'2 is independently a hydrogen atom, alkyl (C1-4) or alkenyl (C2-4) groups, the alkyl or alkenyl groups being preferably substituted by a halogen atom, hydroxyl, keto or dimethylamino group and/or may be interrupted by an oxygen atom; and each R'3 and R'4 is independently a hydrogen atom or methyl group. Preferably, n is an integer from six to ten, R'1 and R'2 are independently hydrogen atoms or methyl groups and R'3 and R'4 are hydrogen atoms. The compounds are useful in treating or preventing, for example, sepsis syndrome, hematopoietic or organ toxicity, baldness, hair loss or allopecia caused by cytotoxic therapies, and progression of an inflammatory or autoimmune disease.

公开(公告)号：AT277049T

公开(公告)日：2004-10-15

申请号：AT94900587

申请日：1993-11-09

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  UNDERINER GAIL E ,  LEIGH ALISTAIR J

IPC: C07D251/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  C07D213/64 ,  C07D239/54 ,  C07D239/62 ,  C07D239/72 ,  C07D471/02 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D473/30

Abstract: Compounds and pharmaceutical compositions thereof comprise the general formula: (R)j - (core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein j is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring structure, R may be selected from the group consisting of a hydrogen, halogen atom, hydroxyl, amino, substituted or unsubstituted benzyl, alkyl (C1-6) or alkenyl (C2-6) group, and at least one R has the general formula I: wherein n is an integer from four to eighteen; each R'1 and R'2 is independently a hydrogen atom, alkyl (C1-4) or alkenyl (C2-4) groups, the alkyl or alkenyl groups being preferably substituted by a halogen atom, hydroxyl, keto or dimethylamino group and/or may be interrupted by an oxygen atom; and each R'3 and R'4 is independently a hydrogen atom or methyl group. Preferably, n is an integer from six to ten, R'1 and R'2 are independently hydrogen atoms or methyl groups and R'3 and R'4 are hydrogen atoms. The compounds are useful in treating or preventing, for example, sepsis syndrome, hematopoietic or organ toxicity, baldness, hair loss or allopecia caused by cytotoxic therapies, and progression of an inflammatory or autoimmune disease.

公开(公告)号：CA2117377A1

公开(公告)日：1994-05-26

申请号：CA2117377

申请日：1993-11-09

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  UNDERINER GAIL E ,  LEIGH ALISTAIR J

IPC: C07D251/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  C07D213/64 ,  C07D239/54 ,  C07D239/62 ,  C07D239/72 ,  C07D471/02 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D473/30 ,  C07D473/00 ,  C07D487/04 ,  C07C225/12 ,  A61K31/13 ,  C07D207/34 ,  A61K31/395 ,  C07C215/54

Abstract: Compounds and pharmaceutical compositions thereof comprise the formula: (R)j - ( core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof , wherein j is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring str ucture, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted benzyl, alky l (C1-6) or alkenyl (C1-6), and at least one R has formula (I), wherein n is an integer from four to eighteen; each R'1 and R'2 is independently hydrogen, alkyl (C1-4) or alkenyl (C1-4), the alkyl or alkenyl groups being preferably substituted by a ha logen, hydroxyl, ketone or dimethylamino group and/or may be interrupted by an oxygen or hydrogen atom or an alkyl (C1-4) group; and each R'3 and R'4 is independently hydrogen or methyl. Preferably, n is an integer from six to ten, R'1 and R'2 are independently hydrogen or methyl and R'3 and R'4 are hydrogen. The compounds are useful in treating or preventing , for example, sepsis syndrome, hematopoietic or organ toxicity, baldness, hair loss or allopecia caused by cytotoxic therapie s, and progression of an inflammatory or autoimmune disease.

公开(公告)号：ES2227522T3

公开(公告)日：2005-04-01

申请号：ES94900587

申请日：1993-11-09

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  UNDERINER GAIL E ,  LEIGH ALISTAIR J

IPC: C07D251/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/517 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  C07D213/64 ,  C07D239/54 ,  C07D239/62 ,  C07D239/72 ,  C07D471/02 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D473/30

Abstract: Compuestos que presentan la fórmula general: **(Fórmula)** incluyendo enantiómeros separados, diastereómeros, hidratos, sales, solvatos y mezclas de los mismos, en la que j es lo un número entero de uno a tres, la parte central es un residuo xantina y los compuestos presentan la fórmula general II **(Fórmula)** en la que R se selecciona de entre el grupo constituido por hidrógeno, átomos halógenos y grupos hidroxilo, amino, benzilo, alquilo (C1-6) o alquenilo con hasta 6 átomos de carbono no sustituidos o sustituidos por un grupo hidroxi, un átomo halógeno o un grupo dimetilamino y al menos un R presenta la fórmula general I: **(Fórmula)** en la que n es un número entero de cuatro a dieciocho; R¿1 y R¿2 son, independientemente, un átomo de hidrógeno, un grupo alquilo (C1-4) o alquenilo con hasta 4 átomos de carbono, opcionalmente interrumpido por un átomo de oxígeno y R¿3 y R¿4 son, independientemente, un átomo de hidrógeno o un grupo metílico con la condición de que R no sea un alquilaminoC6.

公开(公告)号：AU694148B2

公开(公告)日：1998-07-16

申请号：AU1046395

申请日：1994-11-01

Applicant: CELL THERAPEUTICS INC

Inventor： LEUNG DAVID W ,  UNDERINER GAIL E ,  SINGER JACK W

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/40 ,  A61K31/445 ,  A61K31/472 ,  A61K31/505 ,  A61K31/513 ,  A61K31/52 ,  A61P31/12 ,  A61P37/04

公开(公告)号：CH686830A5

公开(公告)日：1996-07-15

申请号：CH371194

申请日：1994-03-31

Applicant: CELL THERAPEUTICS INC

Inventor： MICHNICK JOHN ,  UNDERINER GAIL E ,  KLEIN J PETER ,  RICE GLENN C ,  SUNKARA PRASAD

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/06 ,  C07C215/08 ,  C07C215/56 ,  C07C217/62 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07C237/06 ,  C07D207/40 ,  C07D207/404 ,  C07D207/408 ,  C07D209/48 ,  C07D211/40 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/54 ,  C07D239/90 ,  C07D239/96 ,  C07D295/13 ,  C07D473/10 ,  C07D519/00 ,  C07D473/04 ,  C07C215/02 ,  C07D487/04

公开(公告)号：CA2159640A1

公开(公告)日：1994-10-13

申请号：CA2159640

申请日：1994-03-31

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  MICHNICK JOHN ,  RICE GLENN C ,  UNDERINER GAIL E ,  KUMAR ANIL M

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/06 ,  C07C215/08 ,  C07C215/56 ,  C07C217/62 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07C237/06 ,  C07D207/40 ,  C07D207/404 ,  C07D207/408 ,  C07D209/48 ,  C07D211/40 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/54 ,  C07D239/90 ,  C07D239/96 ,  C07D295/13 ,  C07D473/10 ,  C07D519/00 ,  C07K5/06 ,  A61K31/00 ,  A61K38/05 ,  C07D239/88 ,  C07D473/06

Abstract: The invention provides a group of compounds that are effective agents to inhibit specific cellular signaling events often induced by inflammatory stimuli, to act as anti-inflammatory or immunosupressive agents, to act as cytotoxic agents for treatment of cancers, or to be directly or indirectly antimicrobial to yeast or fungal infections. More specifically, the inventive compounds have at least one amino alcohol (or derivative thereof) functional group on a side chain attached to a core moiety. The inventive compounds are useful antagonists to control intracellular levels of specific sn-2 unsaturated phosphatidic acids and corresponding acid-derived diacylglycerols, intracellular cell signaling messengers which occur in response to pro-inflammatory and selectively proliferative stimuli.

公开(公告)号：PT719267E

公开(公告)日：2002-12-31

申请号：PT94913336

申请日：1994-03-31

Applicant: CELL THERAPEUTICS INC

Inventor： MICHNICK JOHN ,  UNDERINER GAIL E ,  KLEIN PETER J ,  RICE GLENN C ,  SUNKARA PRASAD S ,  KUMAR ANIL M DR

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/06 ,  C07C215/08 ,  C07C215/56 ,  C07C217/62 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07C237/06 ,  C07D207/40 ,  C07D207/404 ,  C07D207/408 ,  C07D209/48 ,  C07D211/40 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/54 ,  C07D239/90 ,  C07D239/96 ,  C07D295/13 ,  C07D473/10 ,  C07D519/00 ,  C07C275/54

公开(公告)号：AU737005B2

公开(公告)日：2001-08-09

申请号：AU9051898

申请日：1998-11-04

Applicant: CELL THERAPEUTICS INC

Inventor： MICHNICK JOHN ,  UNDERINER GAIL E ,  KLEIN PETER J ,  RICE GLENN C ,  SUNKARA PRASAD S

IPC: A61K31/52 ,  C07C215/08 ,  C07C215/10 ,  C07C217/72 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07C237/06 ,  C07D207/40 ,  C07D207/404 ,  C07D209/34 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/22 ,  C07D239/90 ,  C07D239/96 ,  C07D473/04 ,  C07D473/10 ,  C07D475/02