公开(公告)号：AU2007320657B8

公开(公告)日：2012-09-20

申请号：AU2007320657

申请日：2007-11-13

Applicant: CELLMID LTD

Inventor： MATSUI TAKASHI ,  ITO TAKANORI ,  MURAMATSU TAKASHI ,  UNO TSUKASA ,  HAYASHIBARA MASATOSHI

IPC: C07K16/32 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08

Abstract: It is intended to provide an antibody which inhibits the function of midkine. An antibody which recognizes an epitope consisting of amino acid residues 62 to 104 of midkine or a fragment thereof; DNA encoding the antibody or a fragment thereof; a recombinant vector which contains the DNA; a transformant which has the vector or a hybridoma which produces the antibody; a method for producing the antibody by allowing the transformant or hybridoma to produce the antibody or a fragment thereof and collecting the resulting antibody or fragment thereof; a pharmaceutical composition containing the antibody or a fragment thereof as an active ingredient; and a diagnostic agent containing the antibody or a fragment thereof as an active ingredient.