公开(公告)号：AU2007320657B8

公开(公告)日：2012-09-20

申请号：AU2007320657

申请日：2007-11-13

Applicant: CELLMID LTD

Inventor： MATSUI TAKASHI ,  ITO TAKANORI ,  MURAMATSU TAKASHI ,  UNO TSUKASA ,  HAYASHIBARA MASATOSHI

IPC: C07K16/32 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08

Abstract: It is intended to provide an antibody which inhibits the function of midkine. An antibody which recognizes an epitope consisting of amino acid residues 62 to 104 of midkine or a fragment thereof; DNA encoding the antibody or a fragment thereof; a recombinant vector which contains the DNA; a transformant which has the vector or a hybridoma which produces the antibody; a method for producing the antibody by allowing the transformant or hybridoma to produce the antibody or a fragment thereof and collecting the resulting antibody or fragment thereof; a pharmaceutical composition containing the antibody or a fragment thereof as an active ingredient; and a diagnostic agent containing the antibody or a fragment thereof as an active ingredient.

公开(公告)号：JP2011063612A

公开(公告)日：2011-03-31

申请号：JP2010259684

申请日：2010-11-22

Applicant: Cellmid Ltd ,  セルミド リミテッド

Inventor： MURAMATSU TAKASHI ,  INO KAZUHIKO ,  MURAMATSU TOSHIKO ,  TORII SHUHEI

IPC: A61K45/00 ,  A61K31/7088 ,  A61K39/395 ,  A61P41/00 ,  A61P43/00

CPC classification number: A61K31/7088 ,  C07K16/22

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical agent for preventing post-laparotomy adhesion.
SOLUTION: The invention provides an oligonucleotide that suppresses the expression of midkine or an antibody that suppresses the function of midkine, the midkine which is known as a growth factor that enhances cell growth, migration, and survival, and is known for participating in inflammatory responses by promoting the migration of neutrophils and macrophages to inflammatory sites. The oligonucleotide is an antisense oligonucleotide which strongly suppresses midkine expression, inhibits its mRNA translation by hybridizing to midkine mRNA, and inhibits midkine synthesis. An anti-midkine antibody which is an antibody biniding to the midkine may be obtained as a polyclonal or monoclonal antibody.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供用于防止剖腹后粘连的药剂。 解决方案：本发明提供了抑制中期因子或抑制中期因子功能的抗体的寡核苷酸，称为增强细胞生长，迁移和存活的生长因子的中期因子，并且参与已知 通过促进中性粒细胞和巨噬细胞迁移到炎症部位的炎症反应。 寡核苷酸是强烈抑制中期因子表达的反义寡核苷酸，通过与midkine mRNA杂交抑制其mRNA翻译，并抑制中期因子合成。 可以作为多克隆或单克隆抗体获得作为中期因子二联体抗体的抗中期因子抗体。 版权所有（C）2011，JPO＆INPIT