公开(公告)号：WO2005003170A3

公开(公告)日：2005-03-10

申请号：PCT/GB2004002870

申请日：2004-07-01

Applicant: CELLTECH R&D LTD ,  HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  CARRINGTON BRUCE

Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  CARRINGTON BRUCE

IPC: C07K16/24 ,  C07K16/28 ,  A61K47/48

CPC classification number: C07K16/244 ,  C07K16/28 ,  C07K2317/53 ,  C07K2317/55

Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.

Abstract translation: 本发明提供了连接有至少一个效应分子的抗体Fab或Fab'片段，其特征在于片段中的重链不与轻链共价结合，并且CL的链间半胱氨酸和CH1的链间半胱氨酸 已被另一种氨基酸取代。

公开(公告)号：CA2527003A1

公开(公告)日：2005-01-13

申请号：CA2527003

申请日：2004-07-01

Applicant: CELLTECH R&D LTD

Inventor： CARRINGTON BRUCE ,  HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP

IPC: A61K47/48 ,  C07K16/24 ,  C07K16/28

Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chai n in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.