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公开(公告)号：WO03004636A3
公开(公告)日：2003-06-26
申请号：PCT/GB0203129
申请日：2002-07-05
Applicant: CELLTECH R&D LTD , HUMPHREYS DAVID PAUL
Inventor： HUMPHREYS DAVID PAUL
IPC: C12N15/09 , C07K16/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/13 , C12N15/34 , C12P21/08 , C12N15/70
CPC classification number: C12N9/6424 , C07K16/00 , C07K2317/55 , C07K2317/622 , C07K2319/02 , C12N9/16
Abstract: Expression vectors encoding bacteriophage signal peptides are described. The vectors may be used for the heterologous expression and secretion of polypeptides such as antibodies in bacterial host cells.
Abstract translation: 描述编码噬菌体信号肽的表达载体。 载体可用于在细菌宿主细胞中异源表达和分泌多肽，例如抗体。
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公开(公告)号：WO2005003171A3
公开(公告)日：2005-09-29
申请号：PCT/GB2004002871
申请日：2004-07-01
Applicant: CELLTECH R&D LTD , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
Inventor： HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
IPC: C07K16/00 , A61K39/395
CPC classification number: C07K16/00 , C07K2317/55
Abstract: The present invention relates to a new class of antibody fragments including antibody Fab and Fab' fragments in which the heavy chain is not covalently bonded to the light chain and two or more effector molecules are attached to the fragment, of which at least one of said molecules is attached to a cysteine in the heavy or light chain constant region.
Abstract translation: 本发明涉及一类新的抗体片段，包括抗体Fab和Fab'片段，其中重链不与轻链共价结合，并且两个或多个效应分子与片段连接，其中至少一个所述 分子与重链或轻链恒定区中的半胱氨酸连接。
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公开(公告)号：WO2005003169A3
公开(公告)日：2005-05-06
申请号：PCT/GB2004002810
申请日：2004-07-01
Applicant: CELLTECH R&D LTD , HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
IPC: C07K16/00 , A61K39/395
CPC classification number: C07K16/00 , A61K2039/505 , C07K2317/55
Abstract: The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.
Abstract translation: 本发明提供了其中重链恒定区终止于CH1的链间半胱氨酸的抗体Fab片段。 还提供了抗体Fab片段，其中重链恒定区在CH1的链间半胱氨酸处终止于一个或多个效应分子所连接的CH1的链间半胱氨酸。
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公开(公告)号：WO2005003170A3
公开(公告)日：2005-03-10
申请号：PCT/GB2004002870
申请日：2004-07-01
Applicant: CELLTECH R&D LTD , HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP , CARRINGTON BRUCE
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP , CARRINGTON BRUCE
CPC classification number: C07K16/244 , C07K16/28 , C07K2317/53 , C07K2317/55
Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.
Abstract translation: 本发明提供了连接有至少一个效应分子的抗体Fab或Fab'片段，其特征在于片段中的重链不与轻链共价结合，并且CL的链间半胱氨酸和CH1的链间半胱氨酸 已被另一种氨基酸取代。
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Patent Agency Ranking
公开(公告)号：CA2527866A1
公开(公告)日：2005-01-13
申请号：CA2527866
申请日：2004-07-01
Applicant: CELLTECH R&D LTD
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
IPC: C07K16/00 , A61K39/395
Abstract: The present invention relates to a new class of antibody fragments including antibody Fab and Fab' fragments in which the heavy chain is not covalently bonded to the light chain and two or more effector molecules are attached to the fragment, of which at least one of said molecules is attached to a cysteine in the heavy or light chain constant region.
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公开(公告)号：CA2527020A1
公开(公告)日：2005-01-13
申请号：CA2527020
申请日：2004-07-01
Applicant: CELLTECH R&D LTD
Inventor： HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
IPC: C07K16/00 , A61K39/395
Abstract: The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.
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公开(公告)号：CA2452359A1
公开(公告)日：2003-01-16
申请号：CA2452359
申请日：2002-07-05
Applicant: CELLTECH R&D LTD
Inventor： HUMPHREYS DAVID PAUL
IPC: C12N15/09 , C07K16/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/13 , C12N15/34 , C12P21/08 , C12P21/02 , C12N15/62 , C12N15/70
Abstract: Expression vectors encoding bacteriophage signal peptides are described. The vectors may be used for the heterologous expression and secretion of polypeptides such as antibodies in bacterial host cells.
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公开(公告)号：CA2502152A1
公开(公告)日：2004-04-29
申请号：CA2502152
申请日：2003-10-15
Applicant: CELLTECH R&D LTD
Inventor： HUMPHREYS DAVID PAUL , SPITALI MARIANGELA , ROBINSON MARTYN KIM , CHAPMAN ANDREW PAUL
Abstract: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecolihost cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type co~purify with said recombinant antibo dy.
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公开(公告)号：CA2527003A1
公开(公告)日：2005-01-13
申请号：CA2527003
申请日：2004-07-01
Applicant: CELLTECH R&D LTD
Inventor： CARRINGTON BRUCE , HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chai n in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.
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