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公开(公告)号：AT348817T
公开(公告)日：2007-01-15
申请号：AT00940569
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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公开(公告)号：ES2188429B2
公开(公告)日：2005-06-16
申请号：ES200150085
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Se describen pirimidinas de fórmula (I) en la que Ar es un grupo aromático o heteroaromático opcionalmente sustiuido; R1 es un átomo de hidrógeno o un grupo alquilo de cadena lineal o ramificada; R2 es un grupo -X1-R3 en el que X1 es un enlace directo o un átomo o grupo de enlace, y R3 es un grupo alifático, cicloalifático, heteroalifático, heterocicloalifático, aromático o heteroaromático opcionalmente sustituido; y las sales, solvatos, hidratos y N-óxidos del mismo. Los compuestos son inhibidores selectivos de la quinasa KDR y/o la quinasa FGFr y son de utilidad en la profilaxis y tratamiento de estados de enfermedad asociados con la angiogénesis.
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公开(公告)号：GB2369360A
公开(公告)日：2002-05-29
申请号：GB0130563
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R 1 is a hydrogen atom or a straight or branched chain alkyl group: R 2 is a-X 1 -R 3 group where X 1 is a direct bond or a linker atom or group, and R 3 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states associated with angiogenesis.
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公开(公告)号：AU5548800A
公开(公告)日：2001-01-09
申请号：AU5548800
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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公开(公告)号：CA2540881A1
公开(公告)日：2005-05-12
申请号：CA2540881
申请日：2004-10-22
Applicant: CELLTECH R&D LTD
Inventor： HUTCHINGS MARTIN CLIVE , LAING VICTORIA ELIZABETH , TREVITT GRAHAM PETER , ALEXANDER RIKKI PETER , DAVIS JEREMY MARTIN
IPC: C07D495/04 , A61K31/4365 , A61P29/00 , A61P37/00 , C07D221/00 , C07D333/00
Abstract: A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 3-position by an arylcarbonyl or heteroaryl-carbonyl moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.
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Patent Agency Ranking
公开(公告)号：ZA200109841B
公开(公告)日：2003-02-26
申请号：ZA200109841
申请日：2001-11-29
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04 , C07D , A61K , A61P
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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公开(公告)号：HU0201535A2
公开(公告)日：2002-08-28
申请号：HU0201535
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE , MOFFAT DAVID FESTUS CHARLES
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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公开(公告)号：NO20016162A
公开(公告)日：2002-02-18
申请号：NO20016162
申请日：2001-12-17
Applicant: CELLTECH R&D LTD
Inventor： DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE , BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
CPC classification number: C07D239/42 , C07D401/04 , C07D403/12 , C07D409/04
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公开(公告)号：NO20016162D0
公开(公告)日：2001-12-17
申请号：NO20016162
申请日：2001-12-17
Applicant: CELLTECH R&D LTD
Inventor： DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE , BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04 , C07D
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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公开(公告)号：PL352163A1
公开(公告)日：2003-07-28
申请号：PL35216300
申请日：2000-06-19
Applicant: CELLTECH R&D LTD
Inventor： BATCHELOR MARK JAMES , MOFFAT DAVID FESTUS CHARLES , DAVIS JEREMY MARTIN , HUTCHINGS MARTIN CLIVE
IPC: A61K31/505 , A61K31/506 , A61P9/10 , A61P9/14 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/04
Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R is a hydrogen atom or a straight or branched chain alkyl group; R is a -X -R group where X is a direct bond or a linker atom or group, and R is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
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