公开(公告)号：NO20040551A

公开(公告)日：2004-05-10

申请号：NO20040551

申请日：2004-02-06

Applicant: CELLTECH R&D LTD

Inventor： DYKE HAZEL JOAN ,  WATSON ROBERT

IPC: A61K31/453 ,  A61P1/00 ,  A61P1/02 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  C07D309/08 ,  A61K31/445

CPC classification number: C07D405/12

公开(公告)号：NO20040551L

公开(公告)日：2004-05-10

申请号：NO20040551

申请日：2004-02-06

Applicant: CELLTECH R&D LTD

Inventor： DYKE HAZEL JOAN ,  WATSON ROBERT

IPC: A61K31/453 ,  A61P1/00 ,  A61P1/02 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  C07D309/08 ,  A61K31/445

Abstract: Compounds of the general formula (I) are described wherein R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one of R 1 and R 2 is a hydrogen atom, then the other is a CF 3 , CF 2 H or CFH 2 group, and the salts, solvates or hydrates thereof. Compounds of the invention are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. Compounds of the invention may be expected to be of use in medicine, especially where the avoidance of side effects, such as joint pain, is desired.