公开(公告)号：WO2005105143A3

公开(公告)日：2006-04-27

申请号：PCT/GB2005001698

申请日：2005-05-04

Applicant: CELLTECH R&D LTD ,  STAMPS ALASDAIR CRAIG

Inventor： STAMPS ALASDAIR CRAIG

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K39/0011

Abstract: The present invention relates to new uses of LTK in the diagnosis, screening, treatment and prophylaxis of ovarian and lung cancer. The invention also provides compositions comprising LTK, including vaccines, antibodies that are immunospecific for LTK and agents which interact with or modulate the expression or activity of LTK or which modulate the expression of the nucleic acid which codes for LTK.

Abstract translation: 本发明涉及LTK在诊断，筛选，治疗和预防卵巢癌和肺癌中的新用途。 本发明还提供包含LTK的组合物，包括疫苗，对LTK具有免疫特异性的抗体和与LTK的表达或活性相互作用或调节LTK的表达或活性或调节编码LTK的核酸表达的试剂。

公开(公告)号：WO0162784A3

公开(公告)日：2002-01-31

申请号：PCT/GB0100748

申请日：2001-02-21

Applicant: OXFORD GLYCOSCIENCES UK LTD ,  BOYD ROBERT SIMON ,  STAMPS ALASDAIR CRAIG ,  TERRETT JONATHAN ALEXANDER

Inventor： BOYD ROBERT SIMON ,  STAMPS ALASDAIR CRAIG ,  TERRETT JONATHAN ALEXANDER

IPC: G01N33/50 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K47/42 ,  A61K48/00 ,  A61K49/00 ,  A61K51/10 ,  A61P35/00 ,  C07K14/47 ,  C07K16/32 ,  C12M1/00 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/566 ,  G01N33/574 ,  G01N33/577 ,  A61K38/17 ,  C07K16/18 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K9/0019 ,  A61K39/00 ,  A61K47/42 ,  A61K48/00 ,  A61K49/0002 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2319/00 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57434 ,  G01N33/57438 ,  G01N2500/00 ,  G01N2800/52

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of breast cancer, for monitoring the effectiveness of breast cancer treatment, and for drug development.

Abstract translation: 本发明提供乳腺癌筛查，诊断和预后的方法和组合物，用于监测乳腺癌治疗的有效性和用于药物开发。

公开(公告)号：WO0146392A3

公开(公告)日：2001-12-06

申请号：PCT/GB0004963

申请日：2000-12-21

Applicant: OXFORD GLYCOSCIENCES UK LTD ,  MCKENZIE EDWARD ALEXANDER ,  STAMPS ALASDAIR CRAIG ,  TERRETT JONATHAN ALEXANDER ,  TYSON KERRY LOUISE

Inventor： MCKENZIE EDWARD ALEXANDER ,  STAMPS ALASDAIR CRAIG ,  TERRETT JONATHAN ALEXANDER ,  TYSON KERRY LOUISE

IPC: C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/10 ,  A61P7/02 ,  A61P9/08 ,  A61P11/06 ,  A61P17/02 ,  A61P17/16 ,  A61P19/02 ,  A61P25/00 ,  A61P25/28 ,  A61P27/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/24 ,  C12N15/56 ,  A61K38/47

CPC classification number: C12Y302/01166 ,  C12N9/2402

Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.

Abstract translation: 本发明提供了存在于三个剪接变体中的乙酰肝素酶的同源物。

公开(公告)号：WO2006123122A2

公开(公告)日：2006-11-23

申请号：PCT/GB2006001781

申请日：2006-05-16

Applicant: UCB SA ,  STAMPS ALASDAIR CRAIG

Inventor： STAMPS ALASDAIR CRAIG

IPC: A61K39/395 ,  A61K38/17 ,  A61P35/00 ,  G01N33/574

CPC classification number: G01N33/57484 ,  A61K38/1709 ,  A61K39/395 ,  G01N2500/00 ,  G01N2800/52

Abstract: The present invention relates to new uses of PSK-I in the diagnosis, screening, treatment and prophylaxis of ovarian and lung cancer. The invention also provides compositions comprising PSK-I, including vaccines, antibodies that are immunospecific for PSK-I and agents which interact with or modulate the expression or activity of PSK-I or which modulate the expression of the nucleic acid which codes for PSK-I .

Abstract translation: 本发明涉及PSK-1在诊断，筛选，治疗和预防卵巢癌和肺癌中的新用途。 本发明还提供包含PSK-1的组合物，包括疫苗，对PSK-1具有免疫特异性的抗体和与PSK-1的表达或活性相互作用或调节PSK-1的表达或活性或调节编码PSK- 一世 。