公开(公告)号：CA2604661A1

公开(公告)日：2006-10-26

申请号：CA2604661

申请日：2006-04-14

Applicant: CHEMIMAGE CORP

Inventor： DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

IPC: G01J3/44 ,  G01N21/65

Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. T he surface includes a two dimensional area of at least 5 x 105 nm. The enhancin g structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited o n the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

公开(公告)号：WO2006113537A2

公开(公告)日：2006-10-26

申请号：PCT/US2006014252

申请日：2006-04-14

Applicant: CHEMIMAGE CORP ,  DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

Inventor： DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/32 ,  G01N21/658

Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5 x 105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

Abstract translation: 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×105nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

公开(公告)号：EP1844314A4

公开(公告)日：2009-09-23

申请号：EP05756448

申请日：2005-04-28

Applicant: CHEMIMAGE CORP

Inventor： TUSCHEL DAVID ,  MAIER JOHN ,  DEMUTH JOSEPH

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423