中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

50 records (took 0.12 seconds)

    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALSFROM BIOLOGICAL OBJECTS
    5.
    发明专利
    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALSFROM BIOLOGICAL OBJECTS 未知

    公开(公告)号：CA2604661A1

    公开(公告)日：2006-10-26

    申请号：CA2604661

    申请日：2006-04-14

    Applicant: CHEMIMAGE CORP

    Inventor： DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

    IPC: G01J3/44 ,  G01N21/65

    Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. T he surface includes a two dimensional area of at least 5 x 105 nm. The enhancin g structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited o n the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    6.
    发明专利
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 未知

    公开(公告)号：CA2571765A1

    公开(公告)日：2006-01-12

    申请号：CA2571765

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP

    Inventor： TREADO PATRICK J ,  MAIER JOHN S ,  TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/44 ,  G01N21/65

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    DIGITIZING BIOLOGY
    8.
    发明专利
    DIGITIZING BIOLOGY 未知

    公开(公告)号：CA2614319A1

    公开(公告)日：2007-01-25

    申请号：CA2614319

    申请日：2006-07-11

    Applicant: CHEMIMAGE CORP

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  NEISS JASON ,  COHEN JEFFREY

    IPC: A61B5/00 ,  G01J3/00 ,  G01J5/02

    Abstract: A method and apparatus for determining the progress of a disease. A pre- determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

Patent Agency Ranking