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    PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES
    1.
    发明专利
    PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES 未知

    公开(公告)号：CA1262400A

    公开(公告)日：1989-10-17

    申请号：CA267474

    申请日：1976-12-08

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  SELE ALEX

    IPC: C07H3/02 ,  A61K31/195 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07H13/08 ,  C07H15/00 ,  C07H15/04 ,  C07K1/113 ,  C07K9/00

    Abstract: PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES A glucosamine derivative of the general formula (I) in which X denotes a carbonyl or sulphonyl group, R denotes an optionally substituted alkyl radical or an optionally substituted carbocyclic aryl radical and, if X is the carbonyl group, also denotes an alkoxy or benzyloxy radical, R1 denotes hydrogen, alkyl or an optionally substituted benzyl radical, R2 denotes hydrogen or Lower alkyl, R4 and R6 denote hydrogen, alkyl or an optionally substituted benzyl or an acyl radical, R7 denotes hydrogen, alkyl, hydroxymethyl, mercaptomethyl or phenyl, R8 denotes an optionally esterified or amidised carboxyl group and R9 denotes an optionally esterified or amidised carboxyl group, with the proviso that the optionally substituted alkyl radical R has more than 1 carbon atom if X denotes the carbonyl group and the radical R2 denotes methyl; or, if X denotes the carbonyl group, the radical R2 represents hydrogen and R8 and R9 each represent a carboxyl group, and its salts. They have immunity-boosting action.

    PROCESS FOR PREPARING NEW DERIVATIVES OF ANHYDROFURANOSE
    7.
    发明专利
    PROCESS FOR PREPARING NEW DERIVATIVES OF ANHYDROFURANOSE 未知

    公开(公告)号：CS203065B2

    公开(公告)日：1981-02-27

    申请号：CS388473

    申请日：1973-05-29

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  STANEK JAROSLAV ,  ROSSI ALBERTO ,  SELE ALEX

    IPC: C07H19/01 ,  C07H3/10

    Abstract: New anhydrofuranose derivatives of the formula I O ANGLE ANGLE (I) CH - A - O - CH ANGLE CHOR3-CHOR2 wherein R2 is hydrogen, alkyl, aminoalkyl, alkenyl, arylalkyl, or acyl, R3 is hydrogen, alkyl, alkenyl, arylalkyl or acyl and -A-O- is a -CHOR5-CH2-O- or -CH(CH2OR6)-O- radical, wherein R5 or R6 has one of the meanings indicated for R3, or wherein -CH2OR6 represents hydrogen, or wherein two of the radicals R2, R3 and R5 or R6 together represent an ylidene radical, and one of the radicals R2, R3 and R5 or R6 is different from hydrogen if the other two of these radicals are hydrogen, and in compounds with -CHOR5-CH2-O- as the -A-O- radical, one of the radicals R2, R3 and R5 is different from methyl if the other two of these radicals are methyl, and in compounds with -CHOR5-CH2-O- as the -A-O- radical, one of the radicals R2, R3 and R5 is different from acetyl if the other two of these radicals are acetyl, and in compounds with -CHOR5-CH2-O- as the -A-O- radical one of the radicals R2, R3 and R5 is different from p-toluenesulphonyl if the others of these radicals are p-toluenesulphonyl, and in compounds with -CH(CH2OR6)-O- as the -A-O- radical, one of the radicals R2, R3 and R6 is different from benzyl if the other two of these radicals are benzyl, are manufactured by processes which are known per se. They are useful as anti-inflammatory, antiarthritic and analgesic agents.

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