公开(公告)号：WO2004010963A1

公开(公告)日：2004-02-05

申请号：PCT/US2003/022116

申请日：2003-07-16

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CAMPBELL, Thomas, S. ,  SIMONE, Alexander, J. ,  NABI, Nuran ,  COLLINS, Michael

IPC: A61K7/16

CPC classification number: A61K8/0237 ,  A61K8/21 ,  A61K8/29 ,  A61K8/345 ,  A61K8/43 ,  A61K8/73 ,  A61K8/731 ,  A61Q11/00

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.

Abstract translation: 一种双组分氯己定洁齿剂组合物，其改进的储存稳定性，其中第一组分是含有双重双胍类抗菌剂的凝胶，其中凝胶载体用纤维素聚合物增稠，第二组分是含有二氧化硅磨料的糊剂，其中双 当将物理分离的组分在应用于牙科组织时混合并混合时，双胍抗菌剂提供不减少的抗牙龈炎和抗血清病作用，减少染色。

公开(公告)号：WO2003075865A1

公开(公告)日：2003-09-18

申请号：PCT/US2003/006204

申请日：2003-02-27

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： DE PIERRO, Karen, J. ,  CHRISTINA-BECK, Lisa ,  NILES, Hollandra, P. ,  NABI, Nuran ,  SIMONE, Alexander, J. ,  CURTIS, John, P.

IPC: A61K7/00

CPC classification number: A61K8/27 ,  A61K8/35 ,  A61K8/4926 ,  A61Q11/00

Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.

Abstract translation: 已经发现，包含CPC和锌离子的漱口水是非常有效的漱口水。 它具有消除口腔产生气味的细菌的抗菌作用。 CPC和锌离子优选与紫罗兰酮萜烯如α紫罗兰酮或β-紫罗兰酮组合使用。

公开(公告)号：EP1480599A1

公开(公告)日：2004-12-01

申请号：EP03709405.9

申请日：2003-02-27

Applicant: Colgate-Palmolive Company

Inventor： DE PIERRO, Karen, J. ,  CHRISTINA-BECK, Lisa ,  NILES, Hollandra, P. ,  NABI, Nuran ,  SIMONE, Alexander, J. ,  CURTIS, John, P.

IPC: A61K7/00

CPC classification number: A61K8/27 ,  A61K8/35 ,  A61K8/4926 ,  A61Q11/00

Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.

公开(公告)号：EP1553918A1

公开(公告)日：2005-07-20

申请号：EP03771626.3

申请日：2003-07-16

Applicant: Colgate-Palmolive Company

Inventor： CAMPBELL, Thomas, S. ,  SIMONE, Alexander, J. ,  NABI, Nuran ,  COLLINS, Michael

IPC: A61K7/16

CPC classification number: A61K8/0237 ,  A61K8/21 ,  A61K8/29 ,  A61K8/345 ,  A61K8/43 ,  A61K8/73 ,  A61K8/731 ,  A61Q11/00

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.

公开(公告)号：EP1061893B1

公开(公告)日：2002-06-12

申请号：EP99912414.2

申请日：1999-03-11

Applicant: Colgate-Palmolive Company

Inventor： CURTIS, John, P. ,  SIMONE, Alexander, J. ,  GREENFEDER, Susan ,  SIDDIQUI, Zehra

IPC: A61K7/22 ,  A61K7/16

CPC classification number: A61Q11/00 ,  A61K8/43

公开(公告)号：EP1061893A1

公开(公告)日：2000-12-27

申请号：EP99912414.2

申请日：1999-03-11

Applicant: Colgate-Palmolive Company

Inventor： CURTIS, John, P. ,  SIMONE, Alexander, J. ,  GREENFEDER, Susan ,  SIDDIQUI, Zehra

IPC: A61K7/22 ,  A61K7/16

CPC classification number: A61Q11/00 ,  A61K8/43

Abstract: A dual component chlorhexidine dentifrice composition in which the first component contains a bis-biguanide antibacterial agent and the second component contains an abrasive incompatible with the bis-biguanide, wherein maximum antibacterial effect on dental tissue with reduced staining is achieved when the components are physically separated prior to use and are mixed upon application to dental issue.