公开(公告)号：WO2006071675A3

公开(公告)日：2006-07-06

申请号：PCT/US2005/046368

申请日：2005-12-21

Applicant: COLGATE-PALMOLIVE COMPANY ,  TAMBS, Gary, E. ,  ARVANITIDOU, Evangelia, S. ,  NABI, Nuran

Inventor： TAMBS, Gary, E. ,  ARVANITIDOU, Evangelia, S. ,  NABI, Nuran

IPC: A61K8/34 ,  A61Q11/00 ,  A61K8/81 ,  A61K8/22 ,  A61K8/55

Abstract: An oral care (toothpaste) amalgam composition has first and second aqueous phases. The first phase has a measured pH of from about 7 to about 9 and contains 2,4,4’-trichloro-2’-hydroxydiphenyl ether and a methylvinyl ether-maleic anhydride copolymer antibacterial-enhancing agent for the ether. The second aqueous phase has a measured pH of from about 3.5 to about 6.5 and contains hydrogen peroxide and an antioxidant for the hydrogen peroxide. Sodium fluoride, silica, and sodium lauryl sulfate are optionally independently present in at least one of the first and second phases.

公开(公告)号：WO1997046214A1

公开(公告)日：1997-12-11

申请号：PCT/US1997008621

申请日：1997-05-21

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： COLGATE-PALMOLIVE COMPANY ,  MIRAJKAR, Yelloji, Rao, K. ,  AFFLITTO, John ,  NABI, Nuran ,  GAFFAR, Abdul

IPC: A61K07/16

CPC classification number: A61K8/922 ,  A61K8/347 ,  A61K8/463 ,  A61K8/604 ,  A61K8/8164 ,  A61K8/90 ,  A61Q11/00

Abstract: An oral composition comprising in an orally acceptable vehicle, an effective antiplaque amount of an halogenated diphenyl ether or phenolic antibacterial compound, and an amount of a mixed anionic/nonionic surfactant system at weight ratios of about 14:1 to 9:1 which ratios are effective to increase the uptake of the antibacterial compound to dental tissue so as to enhance the therapeutic efficacy of the administered antibacterial compound.

Abstract translation: 一种口服组合物，其包含口腔可接受的载体，有效抗牙釉质量的卤化二苯醚或酚类抗菌化合物，以及一定量的混合阴离子/非离子表面活性剂体系，其重量比为约14:1至9:1， 有效地增加抗菌化合物对牙齿组织的吸收，从而提高施用的抗菌化合物的治疗功效。

公开(公告)号：WO2004010963A1

公开(公告)日：2004-02-05

申请号：PCT/US2003/022116

申请日：2003-07-16

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CAMPBELL, Thomas, S. ,  SIMONE, Alexander, J. ,  NABI, Nuran ,  COLLINS, Michael

IPC: A61K7/16

CPC classification number: A61K8/0237 ,  A61K8/21 ,  A61K8/29 ,  A61K8/345 ,  A61K8/43 ,  A61K8/73 ,  A61K8/731 ,  A61Q11/00

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.

Abstract translation: 一种双组分氯己定洁齿剂组合物，其改进的储存稳定性，其中第一组分是含有双重双胍类抗菌剂的凝胶，其中凝胶载体用纤维素聚合物增稠，第二组分是含有二氧化硅磨料的糊剂，其中双 当将物理分离的组分在应用于牙科组织时混合并混合时，双胍抗菌剂提供不减少的抗牙龈炎和抗血清病作用，减少染色。

公开(公告)号：WO2003075865A1

公开(公告)日：2003-09-18

申请号：PCT/US2003/006204

申请日：2003-02-27

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： DE PIERRO, Karen, J. ,  CHRISTINA-BECK, Lisa ,  NILES, Hollandra, P. ,  NABI, Nuran ,  SIMONE, Alexander, J. ,  CURTIS, John, P.

IPC: A61K7/00

CPC classification number: A61K8/27 ,  A61K8/35 ,  A61K8/4926 ,  A61Q11/00

Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.

Abstract translation: 已经发现，包含CPC和锌离子的漱口水是非常有效的漱口水。 它具有消除口腔产生气味的细菌的抗菌作用。 CPC和锌离子优选与紫罗兰酮萜烯如α紫罗兰酮或β-紫罗兰酮组合使用。

公开(公告)号：EP1835883A2

公开(公告)日：2007-09-26

申请号：EP05855000.5

申请日：2005-12-21

Applicant: Colgate-Palmolive Company

Inventor： TAMBS, Gary E. ,  ARVANITIDOU, Evangelia, S. ,  NABI, Nuran

IPC: A61K8/34

CPC classification number: A61K8/347 ,  A61K8/22 ,  A61K8/55 ,  A61K8/8164 ,  A61K2800/88 ,  A61Q11/00

Abstract: An oral care (toothpaste) amalgam composition has first and second aqueous phases. The first phase has a measured pH of from about 7 to about 9 and contains 2,4,4’-trichloro-2’-hydroxydiphenyl ether and a methylvinyl ether-maleic anhydride copolymer antibacterial-enhancing agent for the ether. The second aqueous phase has a measured pH of from about 3.5 to about 6.5 and contains hydrogen peroxide and an antioxidant for the hydrogen peroxide. Sodium fluoride, silica, and sodium lauryl sulfate are optionally independently present in at least one of the first and second phases.

公开(公告)号：EP1200053B1

公开(公告)日：2005-12-21

申请号：EP00955309.0

申请日：2000-08-01

Applicant: Colgate-Palmolive Company

Inventor： SREENIVASAN, Prem, K. ,  NABI, Nuran ,  GAFFAR, Abdul

IPC: A61K7/16

CPC classification number: A61Q11/00 ,  A61K8/347

Abstract: A stable antibacterial oral composition containing a hydrogenated lupulone and an anionic surfactant.

公开(公告)号：EP1019015A1

公开(公告)日：2000-07-19

申请号：EP98910060.7

申请日：1998-02-27

Applicant: Colgate-Palmolive Company

Inventor： NABI, Nuran ,  GAFFAR, Abdul

IPC: A61K7/16

CPC classification number: A61K8/55 ,  A61K8/347 ,  A61K8/463 ,  A61Q11/00

Abstract: The invention provides an antibacterial oral composition containing an antibacterial compound such as triclosan, a monoalkyl phosphate compound and an anionic surfactant; whereby, the antibacterial effect on dental tissue is substantially increased due to the combined presence of the monoalkyl phosphate compound and the anionic surfactant.

公开(公告)号：EP1480599A1

公开(公告)日：2004-12-01

申请号：EP03709405.9

申请日：2003-02-27

Applicant: Colgate-Palmolive Company

Inventor： DE PIERRO, Karen, J. ,  CHRISTINA-BECK, Lisa ,  NILES, Hollandra, P. ,  NABI, Nuran ,  SIMONE, Alexander, J. ,  CURTIS, John, P.

IPC: A61K7/00

CPC classification number: A61K8/27 ,  A61K8/35 ,  A61K8/4926 ,  A61Q11/00

Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.

公开(公告)号：EP1019015B1

公开(公告)日：2003-02-05

申请号：EP98910060.7

申请日：1998-02-27

Applicant: Colgate-Palmolive Company

Inventor： NABI, Nuran ,  GAFFAR, Abdul

IPC: A61K7/16

CPC classification number: A61K8/55 ,  A61K8/347 ,  A61K8/463 ,  A61Q11/00

Abstract: The invention provides an antibacterial oral composition containing an antibacterial compound such as triclosan, a monoalkyl phosphate compound and an anionic surfactant; whereby, the antibacterial effect on dental tissue is substantially increased due to the combined presence of the monoalkyl phosphate compound and the anionic surfactant.

公开(公告)号：EP1553918A1

公开(公告)日：2005-07-20

申请号：EP03771626.3

申请日：2003-07-16

Applicant: Colgate-Palmolive Company

Inventor： CAMPBELL, Thomas, S. ,  SIMONE, Alexander, J. ,  NABI, Nuran ,  COLLINS, Michael

IPC: A61K7/16

CPC classification number: A61K8/0237 ,  A61K8/21 ,  A61K8/29 ,  A61K8/345 ,  A61K8/43 ,  A61K8/73 ,  A61K8/731 ,  A61Q11/00

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.