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    METHODS OF MODULATING CELL SURFACE RECEPTORS TO PREVENT OR REDUCE INFLAMMATION
    2.
    发明申请
    METHODS OF MODULATING CELL SURFACE RECEPTORS TO PREVENT OR REDUCE INFLAMMATION 审中-公开
    调节细胞表面受体以预防或减少炎症的方法

    公开(公告)号：WO2007082181A2

    公开(公告)日：2007-07-19

    申请号：PCT/US2007/060222

    申请日：2007-01-08

    Applicant: COLGATE-PALMOLIVE COMPANY ,  SREENIVASAN, Prem

    Inventor： SREENIVASAN, Prem

    IPC: G01N33/569 ,  G01N33/50 ,  C12Q1/04

    CPC classification number: G01N33/56955 ,  C12Q1/04 ,  G01N33/6863 ,  G01N2021/6439 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/18 ,  G01N2800/26

    Abstract: The invention includes a method of distinguishing among oral bacteria species to determine whether a species is orally deleterious. Such method includes contacting at least one bacterium or portion of a bacterium of a species of oral bacteria a gingival cell; and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that the species of bacteria is not a deleterious species. Also included within the scope of the invention are methods for determining the anti¬ inflammatory effect of an agent. Such methods include contacting the cell with the agent in the presence of a deleterious bacterium or portion of such bacterium and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that agent is an anti-inflammatory agent.

    Abstract translation: 本发明包括区分口腔细菌种类的方法，以确定物种是否具有口腔毒性。 这种方法包括使口腔细菌种类的至少一种细菌或部分接触牙龈细胞; 并检测指示剂化合物的存在。 指示物质的实质缺乏表示细菌种类不是有害物质。 还包括在本发明的范围内的是确定试剂的抗炎作用的方法。 这样的方法包括在有害细菌或这种细菌的一部分存在下使细胞与试剂接触并检测指示剂化合物的存在。 指示剂物质的实质缺乏表示该试剂是抗炎剂。

    ASSAY FOR ORAL INFLAMMATION
    4.
    发明申请
    ASSAY FOR ORAL INFLAMMATION 审中-公开
    测定口腔炎症

    公开(公告)号：WO2015187169A1

    公开(公告)日：2015-12-10

    申请号：PCT/US2014/041158

    申请日：2014-06-05

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： SREENIVASAN, Prem

    IPC: G01N33/569

    CPC classification number: G01N33/56955 ,  G01N2333/79 ,  G01N2800/18 ,  G01N2800/52

    Abstract: Methods and kits for determining the presence or severity of oral inflammation, such as gingivitis or periodontitis wherein the determination method comprises: (a) obtaining a test sample of oral material from said subject; (b) determining the amount of polymorphonuclear neutrophil indicator substance in said test sample; and (c) comparing the amount of polymorphonuclear neutrophil indicator substance in the test sample to a control sample.

    Abstract translation: 用于确定口腔炎症的存在或严重性的方法和试剂盒，例如牙龈炎或牙周炎，其中所述测定方法包括：（a）从所述受试者获得口服材料的测试样品; （b）确定所述测试样品中多形核嗜中性粒细胞指示物质的量; 和（c）将测试样品中的多形核嗜中性粒细胞指示物质的量与对照样品进行比较。

    ORAL HEALTH INDEX
    5.
    发明申请
    ORAL HEALTH INDEX 审中-公开
    口腔健康指数

    公开(公告)号：WO2012005719A2

    公开(公告)日：2012-01-12

    申请号：PCT/US2010/040508

    申请日：2010-06-30

    Applicant: COLGATE-PALMOLIVE COMPANY ,  SREENIVASAN, Prem

    Inventor： SREENIVASAN, Prem

    IPC: A61Q11/00 ,  G01N33/50

    CPC classification number: A61C19/04 ,  A61K8/922 ,  A61K8/97 ,  A61Q11/00 ,  G01N33/6893 ,  G01N2800/18 ,  G06F19/00 ,  G16H50/30

    Abstract: Methods of measuring a subject's Ayurvedic oral health are disclosed. The methods include examining the subject and assigning a health score for each of one or more Ayurvedic oral health parameters. The scores can be used to compare the Ayurvedic oral health of different populations, to assess changes in a subject's Ayurvedic oral health, and to assess the efficacy of Ayurvedic treatments.

    Abstract translation: 公开了测量受试者的阿育吠陀口腔健康的方法。 该方法包括检查对象并为一个或多个印度医学口腔健康参数中的每一个指定健康分数。 评分可用于比较不同人群的阿育吠陀口腔健康状况，评估受试者的阿育吠陀口腔健康状况变化，并评估阿育吠陀疗法的疗效。

    METHODS OF MODULATING CELL SURFACE RECEPTORS TO PREVENT OR REDUCE INFLAMMATION
    6.
    发明公开
    METHODS OF MODULATING CELL SURFACE RECEPTORS TO PREVENT OR REDUCE INFLAMMATION 无效
    方法调制的细胞表面受体，以防止或炎症减弱

    公开(公告)号：EP1971865A2

    公开(公告)日：2008-09-24

    申请号：EP07709990.1

    申请日：2007-01-08

    Applicant: Colgate-Palmolive Company

    Inventor： SREENIVASAN, Prem

    IPC: G01N33/569 ,  G01N33/50 ,  C12Q1/04 ,  G01N33/68

    CPC classification number: G01N33/56955 ,  C12Q1/04 ,  G01N33/6863 ,  G01N2021/6439 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/18 ,  G01N2800/26

    Abstract: The invention includes a method of distinguishing among oral bacteria species to determine whether a species is orally deleterious. Such method includes contacting at least one bacterium or portion of a bacterium of a species of oral bacteria a gingival cell; and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that the species of bacteria is not a deleterious species. Also included within the scope of the invention are methods for determining the anti¬ inflammatory effect of an agent. Such methods include contacting the cell with the agent in the presence of a deleterious bacterium or portion of such bacterium and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that agent is an anti-inflammatory agent.

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