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    ORAL CARE COMPOSITIONS
    1.
    发明申请
    ORAL CARE COMPOSITIONS 审中-公开
    口腔护理组合物

    公开(公告)号：WO2017062020A1

    公开(公告)日：2017-04-13

    申请号：PCT/US2015/054791

    申请日：2015-10-08

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： REGE, Aarti ,  SURIANO, David ,  SULLIVAN, Richard

    IPC: A61Q11/00 ,  A61K8/27 ,  A61K8/25 ,  A61K8/19 ,  A61K8/26 ,  A61K8/24 ,  A61K8/21

    CPC classification number: A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/26

    Abstract: An oral care composition comprising at least one metal phosphate chosen from stannous phosphate, magnesium phosphate or aluminum phosphate; and at least one fluoride ion source. The at least one phosphate is added to the oral care composition as a preformed salt. Methods of administering the oral care composition to a subject are also disclosed.

    Abstract translation: 一种口服护理组合物，其包含至少一种选自磷酸亚锡，磷酸镁或磷酸铝的金属磷酸盐; 和至少一种氟离子源。 将至少一种磷酸盐作为预成型盐加入到口腔护理组合物中。 还公开了向受试者施用口腔护理组合物的方法。

    ORAL BIOFILM MODELS AND USES THEREOF
    2.
    发明申请
    ORAL BIOFILM MODELS AND USES THEREOF 审中-公开
    口腔生物模型及其用途

    公开(公告)号：WO2016057019A1

    公开(公告)日：2016-04-14

    申请号：PCT/US2014/059376

    申请日：2014-10-06

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： RINAUDI MARRON, Luciana ,  SULLIVAN, Richard ,  SURIANO, David ,  REGE, Aarti ,  SANTARPIA III, Ralph Peter

    IPC: C12M1/12 ,  C12Q1/18

    CPC classification number: C12Q1/18 ,  C12N1/20 ,  G01N1/2806

    Abstract: The present disclosure provides an oral biofilm model including a substrate including a first surface, a second surface, and a plurality of specimens fixedly attached to the first surface, wherein an oral biofilm is capable of forming on the specimen. The surface roughness of at least one of the specimens of the plurality is less than or greater than a surface roughness of at least a second specimen of the plurality. The oral biofilm model also includes a body having sides and a bottom defining a vessel. The body is adapted to receive the substrate and the plurality of specimens and is further adapted to receive a fluid. Methods of forming oral biofilms and methods for identifying an agent for reducing or inhibiting biofilm formation are also provided.

    Abstract translation: 本公开内容提供了一种口腔生物膜模型，其包括基底，其包括第一表面，第二表面和固定地连接到第一表面的多个样本，其中口腔生物膜能够在样本上形成。 多个试样的至少一个的表面粗糙度小于或大于多个试样的表面粗糙度。 口腔生物膜模型还包括具有限定容器的侧面和底部的主体。 本体适于接收基底和多个样本，并且还适于接收流体。 还提供了形成口腔生物膜的方法和用于鉴定用于减少或抑制生物膜形成的试剂的方法。

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