公开(公告)号：WO2011160636A2

公开(公告)日：2011-12-29

申请号：PCT/DK2011/050224

申请日：2011-06-22

Applicant: COLOPLAST A/S ,  NIELSEN, Christian, B. ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

Inventor： NIELSEN, Christian, B. ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: C08F2/50 ,  C08F2/48 ,  C08F12/14 ,  C08J3/28

CPC classification number: C08F8/00 ,  C08F2/48 ,  C08F2/50 ,  C08F255/02 ,  C08F283/06 ,  C08J3/075 ,  C08J3/28 ,  C08J2400/22 ,  C08F2220/301 ,  C08F220/58 ,  C08F216/1416 ,  C08F226/02 ,  C08F212/14 ,  C08F216/36

Abstract: The invention provides a method for producing a polymeric photoinitiator, of the general formula I : Polymer-[CR2-CHR-Spacer(PI) n ] m (I) wherein m is an integer from 1-5000; n is a real number above 0 and below 5; R is as defined herein, and PI is a photoinitiator moiety. The method comprises grafting one or more photoinitiator moieties (PI), each of which comprises at least one activated alkene functional group, onto the polymer. Polymeric photoinitiators are also provided.

Abstract translation: 本发明提供了通式I的聚合物光引发剂的制备方法：聚合物 - [CR 2 -CHR-隔离剂（PI）n] m（I），其中m是1-5000的整数; n是0以上5以下的实数; R如本文所定义，并且PI是光引发剂部分。 该方法包括将一种或多种光引发剂部分（PI）接枝到聚合物上，每个光引发剂部分（PI）包含至少一个活化烯官能团。 还提供聚合物光引发剂。

公开(公告)号：WO2011160640A2

公开(公告)日：2011-12-29

申请号：PCT/DK2011/050228

申请日：2011-06-22

Applicant: COLOPLAST A/S ,  NIELSEN, Christian, B. ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

Inventor： NIELSEN, Christian, B. ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: C08F2/50

CPC classification number: C08J3/075 ,  C08F2/50 ,  C08G65/22 ,  C08J3/28 ,  C08J2300/14 ,  C08J2371/02 ,  C08J2400/10 ,  C08L71/02 ,  C08L2312/06

Abstract: The invention provides a method for the manufacture of a gel, said method comprising the steps of: providing a matrix composition comprising a polymeric photoinitiator of the general formula (I) : Polymer-[CR 2 -CHR-Spacer(PI) n ] m (I) curing the matrix composition by exposing it to UV radiation and exposing the matrix composition to a swelling medium. The invention also relates to gels obtainable via the above method. The invention provides a hydrophilic gel precursor manufactured from the polymeric photoinitiator of Formula (I). Medical devices comprising the gels and hydrophilic gel precursors of the invention are provided. The invention also provides the use of a polymeric photoinitiator in the manufacture of a gel.

Abstract translation: 本发明提供一种制造凝胶的方​​法，所述方法包括以下步骤：提供包含通式（I）的聚合物光引发剂的基质组合物：聚合物 - [CR 2 -CHR-间隔物（PI）n] m（ I）通过将基质组合物暴露于UV辐射并使基质组合物暴露于溶胀介质来固化基质组合物。 本发明还涉及通过上述方法可获得的凝胶。 本发明提供由式（I）的聚合物光引发剂制备的亲水凝胶前体。 提供包含本发明的凝胶和亲水凝胶前体的医疗装置。 本发明还提供聚合物光引发剂在制造凝胶中的用途。

公开(公告)号：EP2394676B1

公开(公告)日：2018-03-28

申请号：EP11177367.7

申请日：2007-12-14

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud ,  HOEJ, Carsten ,  NIELSEN, Christian B. ,  MADSEN, Niels Joergen

IPC: A61L29/08 ,  A61L17/14 ,  C08J7/04 ,  C08J7/12 ,  C08G65/331 ,  A61L27/34 ,  A61L31/10 ,  C09D171/02 ,  C08L23/36 ,  C08L71/02

CPC classification number: A61L29/085 ,  A61L17/145 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  C08G65/331 ,  C08J7/047 ,  C08J7/123 ,  C08J2471/00 ,  C08L23/36 ,  C08L71/02 ,  C09D171/02 ,  C08L2666/04

Abstract: The application discloses a method for the preparation (by extruding, injection moulding or powder coating and subsequent cross-linking by irradiation with UV or visible light) of a medical device element involving a coating composition comprising (a) as the only polymer constituent(s), at least 50 % by weight of poly(ethylene oxide)(s) optionally in combination with non-thermoplastic hydrophilic polymer(s), and (b) low molecular weight scaffold(s) having a plurality of photo-initiator moieties covalently linked thereto and/or covalently incorporated therein, wherein the photo-initiator moieties constitute 0.01-20 % by weight of the combined amount of the poly(ethylene oxide)(s), any non-thermoplastic hydrophilic polymers and the low molecular weight scaffolds. The application further discloses such extruded, injection moulded or powder coated medical devices having thereon a layer of a covalently cross-linked coating composition of a poly(ethylene oxide) (PEO), optionally a non-thermoplastic hydrophilic polymer and a low molecular weight scaffold having a plurality of residues of photo-initiator moieties.

公开(公告)号：EP2892935A1

公开(公告)日：2015-07-15

申请号：EP13725530.3

申请日：2013-05-17

Applicant: Lubrizol Advanced Materials, Inc. ,  Coloplast A/S

Inventor： HOEJ, Carsten ,  MADSEN, Niels Joergen ,  MAKAL, Umit G.

IPC: C08G18/10 ,  C08G18/48 ,  C08G18/76 ,  C08L75/08

CPC classification number: C08L75/04 ,  C08G18/10 ,  C08G18/48 ,  C08G18/4854 ,  C08G18/76 ,  C08L23/06 ,  C08L23/12 ,  C08L75/08 ,  C08L23/08 ,  C08G18/3206

Abstract: This invention relates to an alloy comprising polyurethane and polyolefin. It has now surprisingly been found that a specific composition of polyolefin and polyurethane has surprising mechanical properties and at the same time has transparent characteristics and/or appearance. The present invention provides an alloy with remarkable mechanical properties. The phases do not macro-phase separate. Thus, this stable and potentially broad interface is very effective in stress transfer when the alloy is strained. As one might expect, the hardness values for the alloys are in between the hardness values of each component but the other physical properties are no adjusted. In this way, when considering the hardness and mechanical values, these alloys behave like two compatible polymers.

Abstract translation: 本发明涉及包含聚氨酯和聚烯烃的合金。 现在惊奇地发现，聚烯烃和聚氨酯的具体组合物具有惊人的机械性能，同时具有透明特性和/或外观。 本发明提供具有显着机械性能的合金。 这些阶段不是宏相分离的。 因此，当合金应变时，这种稳定且潜在的宽界面在应力传递中非常有效。 可以预期，合金的硬度值在每个组分的硬度值之间，但其他物理性能没有调整。 以这种方式，当考虑硬度和机械值时，这些合金表现得像两种相容的聚合物。

公开(公告)号：WO2019034221A1

公开(公告)日：2019-02-21

申请号：PCT/DK2018/050198

申请日：2018-08-16

Applicant: COLOPLAST A/S

Inventor： HOEJ, Carsten ,  MADSEN, Niels Joergen ,  SEHNAL, Petr ,  TOWNS, Andrew ,  JEPSON, David

IPC: C08F2/50 ,  C08F22/36 ,  C08F8/32 ,  C08F8/48 ,  C08F22/06 ,  C08F222/06 ,  C08F216/18 ,  C08F222/36

Abstract: Polymers are provided, in which a pendant photoinitiator moiety is linked to the polymer structure via an amide or a succinimide.

公开(公告)号：WO2013176978A1

公开(公告)日：2013-11-28

申请号：PCT/US2013/041544

申请日：2013-05-17

Applicant: LUBRIZOL ADVANCED MATERIALS, INC. ,  COLOPLAST A/S

Inventor： HOEJ, Carsten ,  MADSEN, Niels Joergen ,  MAKAL, Umit G.

IPC: C08G18/10 ,  C08G18/48 ,  C08G18/76 ,  C08L75/08

CPC classification number: C08L75/04 ,  C08G18/10 ,  C08G18/48 ,  C08G18/4854 ,  C08G18/76 ,  C08L23/06 ,  C08L23/12 ,  C08L75/08 ,  C08L23/08 ,  C08G18/3206

Abstract: This invention relates to an alloy comprising polyurethane and polyolefin. It has now surprisingly been found that a specific composition of polyolefin and polyurethane has surprising mechanical properties and at the same time has transparent characteristics and/or appearance. The present invention provides an alloy with remarkable mechanical properties. The phases do not macro-phase separate. Thus, this stable and potentially broad interface is very effective in stress transfer when the alloy is strained. As one might expect, the hardness values for the alloys are in between the hardness values of each component but the other physical properties are no adjusted. In this way, when considering the hardness and mechanical values, these alloys behave like two compatible polymers.

Abstract translation: 本发明涉及包含聚氨酯和聚烯烃的合金。 现在令人惊奇地发现，聚烯烃和聚氨酯的特定组合物具有惊人的机械性能，同时具有透明特性和/或外观。 本发明提供具有显着机械性能的合金。 这些阶段不是宏相分离的。 因此，当合金应变时，这种稳定和潜在的宽界面在应力传递中非常有效。 可以预期的是，合金的硬度值在每个组分的硬度值之间，但其他物理性能没有调整。 以这种方式，当考虑硬度和机械值时，这些合金表现得像两种相容的聚合物。

公开(公告)号：WO2006018026A1

公开(公告)日：2006-02-23

申请号：PCT/DK2005/000532

申请日：2005-08-19

Applicant: COLOPLAST A/S ,  TRUELSEN, Jens, Hoeg ,  NIELSEN, Brian ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

Inventor： TRUELSEN, Jens, Hoeg ,  NIELSEN, Brian ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: A61L15/26

CPC classification number: A61L15/26 ,  D01F6/44 ,  Y10T442/2377 ,  Y10T442/2484

Abstract: An absorbent fibrous material comprising fibers prepared by melt spinning, solvent spinning, dry spinning or electro spinning of a polymer composition having a water absorption capacity of at least 10g/g polymer composition and comprising a thermoplastic hydrophilic block copolymer as well as wound dressings comprising such absorbent fibrous material.

Abstract translation: 一种吸收性纤维材料，其包含通过熔体纺丝，溶剂纺丝，干法纺丝或具有至少10g / g聚合物组合物的吸水能力的聚合物组合物的电纺丝制备的纤维，并且包含热塑性亲水性嵌段共聚物以及包含这样的缠绕敷料 吸收性纤维材料。

公开(公告)号：WO2005033198A1

公开(公告)日：2005-04-14

申请号：PCT/DK2004/000677

申请日：2004-10-07

Applicant: COLOPLAST A/S ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

Inventor： MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: C08L39/06

CPC classification number: A61L15/585 ,  A61B5/4839 ,  C08F293/005 ,  C08L33/08 ,  C08L39/06 ,  C08L53/00 ,  C08L53/02 ,  C08L71/00 ,  C08L2666/02 ,  C08L2666/10 ,  C08L2666/24 ,  C09J133/08 ,  C09J135/06 ,  C09J139/06 ,  C09J153/00 ,  C09J153/02 ,  C09J2201/606 ,  C08L71/02

Abstract: A pressure sensitive adhesive composition comprising one or more hydrogel-forming hydrophilic homopolymers or heteropolymers and one or more amphiphilic block-copolymers comprising hydrophobic polymer blocks being incompatible and hydrophilic polymer blocks is useful, for example, in transdermal drug delivery systems and other medical, pharmaceutical and cosmetic products that adhere to the skin or other body surface.

Abstract translation: 包含一种或多种形成水凝胶的亲水均聚物或杂聚物的压敏粘合剂组合物和包含不相容和亲水性聚合物嵌段的疏水聚合物嵌段的一种或多种两亲性嵌段共聚物可用于例如透皮药物递送系统和其它医疗药物 以及粘附于皮肤或其他身体表面的化妆品。

公开(公告)号：EP2585496A2

公开(公告)日：2013-05-01

申请号：EP11731249.6

申请日：2011-06-22

Applicant: Coloplast A/S

Inventor： NIELSEN, Christian, B. ,  MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: C08F2/50

CPC classification number: C08J3/075 ,  C08F2/50 ,  C08G65/22 ,  C08J3/28 ,  C08J2300/14 ,  C08J2371/02 ,  C08J2400/10 ,  C08L71/02 ,  C08L2312/06

Abstract: The invention provides a method for the manufacture of a gel, said method comprising the steps of: providing a matrix composition comprising a polymeric photoinitiator of the general formula (I) : Polymer-[CR
2 -CHR-Spacer(PI)
n ]
m (I) curing the matrix composition by exposing it to UV radiation and exposing the matrix composition to a swelling medium. The invention also relates to gels obtainable via the above method. The invention provides a hydrophilic gel precursor manufactured from the polymeric photoinitiator of Formula (I). Medical devices comprising the gels and hydrophilic gel precursors of the invention are provided. The invention also provides the use of a polymeric photoinitiator in the manufacture of a gel.

Abstract translation: 本发明提供了制备凝胶的方法，所述方法包括以下步骤：提供包含通式（I）的聚合物光引发剂的基质组合物：聚合物 - [CR 2 -CHR-间隔物（PI）n] m（ I）通过将基质组合物暴露于UV辐射并将基质组合物暴露于溶胀介质中来固化基质组合物。 本发明还涉及通过上述方法可获得的凝胶。 本发明提供由式（I）的聚合物光引发剂制备的亲水凝胶前体。 提供包含本发明的凝胶和亲水凝胶前体的医疗装置。 本发明还提供聚合物光引发剂在制造凝胶中的用途。

公开(公告)号：EP1675908B1

公开(公告)日：2008-12-17

申请号：EP04762896.1

申请日：2004-10-07

Applicant: COLOPLAST A/S

Inventor： MADSEN, Niels, Joergen ,  HOEJ, Carsten

IPC: C08L39/06 ,  C08L53/00 ,  C09J139/06 ,  C09J153/00 ,  A61L24/00 ,  A61L15/24

CPC classification number: A61L15/585 ,  A61B5/4839 ,  C08F293/005 ,  C08L33/08 ,  C08L39/06 ,  C08L53/00 ,  C08L53/02 ,  C08L71/00 ,  C08L2666/02 ,  C08L2666/10 ,  C08L2666/24 ,  C09J133/08 ,  C09J135/06 ,  C09J139/06 ,  C09J153/00 ,  C09J153/02 ,  C09J2201/606 ,  C08L71/02

Abstract: The present invention relates to a medical device having a wetted hydrophilic coating comprising: a coating composition containing a hydrophilic polymer and a wetting agent comprising water and one or more lubricant(s).