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公开(公告)号：WO2015151070A3
公开(公告)日：2015-11-26
申请号：PCT/IB2015052462
申请日：2015-04-03
Applicant: COMMISSARIAT ENERGIE ATOMIQUE
Inventor： VIEL PASCAL , BERTHELOT THOMAS , LEFEVRE XAVIER , POLESEL MARIS JÉRÔME
CPC classification number: B05D7/24 , B05D3/0254 , B05D3/064 , B05D3/067 , B05D3/107 , B05D3/108 , B05D3/12 , B05D7/144
Abstract: The invention relates to a method for functionalising a surface of a solid substrate with at least one acrylic acid polymer layer, said method comprising the steps of: i) placing said surface in contact with a solution consisting of at least one acrylic acid homopolymer, a solvent and, optionally, metal salts; ii) removing the solvent from the solution in contact with said surface; and iii) binding the polymer to said surface by thermal treatment.
Abstract translation: 本发明涉及一种用至少一种丙烯酸聚合物层对固体基质的表面进行功能化的方法，所述方法包括以下步骤：i）将所述表面与由至少一种丙烯酸均聚物， 溶剂，和任选的金属盐; ii）从与所述表面接触的溶液中除去溶剂; 和iii）通过热处理将聚合物结合到所述表面。
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2.发明申请METHOD FOR CHEMICALLY MODIFYING A POLYMER MATRIX THROUGH THE THICKNESS THEREOF 审中-公开通过其厚度对聚合物基质进行化学修饰的方法
公开(公告)号：WO2010125191A3
公开(公告)日：2011-01-13
申请号：PCT/EP2010055923
申请日：2010-04-30
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , BERTHELOT THOMAS , BAUDIN CECILE
Inventor： BERTHELOT THOMAS , BAUDIN CECILE
CPC classification number: C23C18/1601 , C08J3/28 , C08J7/123 , C08J7/16 , C08J2323/26 , C08J2327/18 , C23C18/18 , C23C18/1844 , C23C18/1893 , C23C18/2086 , Y10T428/1352
Abstract: The invention relates to a method for chemically modifying a polymer matrix through the thickness thereof, said polymer matrix being selected from among fluoropolymer matrices and aliphatic polymer matrices. The method includes at least one step consisting in irradiating the matrix with UV light having a wavelength of less than 300 nm in order to generate zones in the thickness of the matrix that have: short polymer chains formed by scission of the existing chains during the passage of the UV rays, and free radicals known as "activated zones". The invention also relates to the polymer matrix that can be chemically modified using one such method.
Abstract translation: 本发明涉及一种通过其聚合物基体的厚度对聚合物基质进行化学改性的方法，所述聚合物基体选自含氟聚合物基体和脂族聚合物基质。 该方法包括至少一个步骤，其包括用波长小于300nm的UV光照射基质，以便产生基质厚度的区域，该区域具有：在通道期间通过现有链条的断开而形成的短聚合物链 的紫外线，以及称为“活化区”的自由基。 本发明还涉及可以使用一种这样的方法化学改性的聚合物基质。
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3.发明申请METHOD FOR PREPARING A METALLISED SUBSTRATE, THE RESULTING SUBSTRATE AND THE USES THEREOF 审中-公开制备金属基材，结晶基板及其用途的方法
公开(公告)号：WO2010125189A2
公开(公告)日：2010-11-04
申请号：PCT/EP2010055920
申请日：2010-04-30
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , BERTHELOT THOMAS , VIEL PASCAL , GARCIA ALEXANDRE , ROUSSEL SEBASTIEN
Inventor： BERTHELOT THOMAS , VIEL PASCAL , GARCIA ALEXANDRE , ROUSSEL SEBASTIEN
CPC classification number: C23C18/1601 , C08J3/28 , C08J7/123 , C08J7/16 , C08J2323/26 , C08J2327/18 , C23C18/18 , C23C18/1844 , C23C18/1893 , C23C18/2086 , Y10T428/1352
Abstract: The invention relates to a method for preparing a metallised substrate, comprising the following steps consisting in: grafting a polymer-type compound to the substrate, said compound optionally having a group capable of chelating at least one metal ion; bringing the aforementioned compound, which is capable of chelating at least one metal ion, into contact with at least one metal ion, exposing said polymer-type compound to conditions that allow the reduction of the chelated metal ion(s) and repeating the chelation/reduction steps until a metallised substrate is obtained. The invention also relates to the resulting substrates and to the uses thereof.
Abstract translation: 本发明涉及一种制备金属化基材的方法，包括以下步骤：将聚合物型化合物接枝到基材上，所述化合物任选具有能螯合至少一种金属离子的基团; 使能够螯合至少一种金属离子的上述化合物与至少一种金属离子接触，将所述聚合物型化合物暴露于允许还原螯合金属离子并重复螯合/ 还原步骤直到获得金属化的基底。 本发明还涉及所得到的基材及其用途。
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4.发明申请FLUORESCENT CYCLIC PEPTIDES, METHODS FOR THE PREPARATION THEREOF, AND USE OF SAID PEPTIDES FOR MEASURING THE ENZYMATIC ACTIVITY OF A PROTEASE ENZYME 审中-公开荧光素环肽，其制备方法以及用于测定蛋白酶的酶活性的同位素的用途
公开(公告)号：WO2010000591A3
公开(公告)日：2010-05-27
申请号：PCT/EP2009057194
申请日：2009-06-10
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , UNIV VICTOR SEGALEN BORDEAUX 2 , BERTHELOT THOMAS , DELERIS GERARD
Inventor： BERTHELOT THOMAS , DELERIS GERARD
CPC classification number: C12Q1/37 , C07K7/64 , G01N2333/95 , G01N2333/96494
Abstract: The invention relates to a cyclic peptide comprising the following sequence: -S1-X1-S2-X2- wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 can be the same or different, the first peptide sequence S1 and the second peptide sequence S2 comprising between 4 and 14 amino acids, E1 and E2 corresponding to the same protease enzyme or to two separate protease enzymes, X1 is a probe carrying a fluorescent donor group, and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Said peptides can be used in determining the activity of protease enzymes.
Abstract translation: 本发明涉及包含以下序列的环肽：-S1-X1-S2-X2-，其中S1是蛋白酶E1的第一个靶肽序列，S2是蛋白酶E2的第二个靶肽序列，S1和 S2可以相同或不同，第一个肽序列S1和第二个肽序列S2包含4到14个氨基酸，E1和E2对应于相同的蛋白酶或两个独立的蛋白酶，X1是携带荧光的探针 供体组，X2是携带荧光或非荧光受体组的探针。 所述肽可用于测定蛋白酶的活性。
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公开(公告)号：WO2010000592A2
公开(公告)日：2010-01-07
申请号：PCT/EP2009057202
申请日：2009-06-10
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , UNIV VICTOR SEGALEN BORDEAUX 2 , BERTHELOT THOMAS , DELERIS GERARD
Inventor： BERTHELOT THOMAS , DELERIS GERARD
CPC classification number: C07K7/64 , A61K38/00 , C07K14/8146
Abstract: The invention relates to a cyclopeptide of the following formula: wherein: - S1 is a target peptide sequence of an MMP enzyme, that is a peptide sequence that can be identified and cleaved by an MMP enzyme; - M1 and M2 are independently a single bond, a hydrocarbonated group or an amino acid residue, optionally carrier of an aromatic side group; - X and Y are independently a single bond, and a linear or branched hydrocarbonated group that can have, in its chain, at least one heteroatom or an amino acid residue. Said cyclopeptides can be used as MMP protease enzyme inhibitors.
Abstract translation: 本发明涉及下式的环肽：其中：-S1是MMP酶的靶肽序列，其是可被MMP酶鉴定和切割的肽序列; -M1和M2独立地为单键，烃化基团或氨基酸残基，任选芳族侧基的载体; - X和Y独立地为单键，以及在其链中可以具有至少一个杂原子或氨基酸残基的直链或支链烃基。 所述环肽可以用作MMP蛋白酶抑制剂。
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Patent Agency Ranking6.发明申请METHOD FOR ASSEMBLING TWO SURFACES, OR ONE SURFACE, WITH A MOLECULE OF INTEREST 审中-公开用于组装两个表面或一个表面的方法，具有感兴趣的分子
公开(公告)号：WO2009121944A3
公开(公告)日：2009-12-10
申请号：PCT/EP2009053977
申请日：2009-04-02
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , BERTHELOT THOMAS , DENIAU GUY , HUC VINCENT , LE XUAN TUAN , NEKELSON FABIEN , ROUSSEL SEBASTIEN , VIEL PASCAL
Inventor： BERTHELOT THOMAS , DENIAU GUY , HUC VINCENT , LE XUAN TUAN , NEKELSON FABIEN , ROUSSEL SEBASTIEN , VIEL PASCAL
IPC: C09J5/00
CPC classification number: C09J5/02 , G01N33/54353 , G01N2035/00158 , Y10T156/10
Abstract: The present invention relates to a method for assembling at least one area of a first surface with at least one area of a second surface or with a molecule of interest, including a step consisting of placing said area of said first surface in contact with said area of said second surface or with said molecule of interest, wherein said area of said first surface exhibits at least one radical and/or ionic entity. The present invention also relates to a solid substrate the surface of which has at least one area with at least one radical and/or ionic entity, with at least one adhesion primary, or with at least one precursor of an adhesion primary, and to the various uses thereof.
Abstract translation: 本发明涉及一种用于将第一表面的至少一个区域与第二表面的至少一个区域或感兴趣的分子组装的方法，包括将所述第一表面的所述区域与所述区域接触的步骤 的所述第二表面或所述感兴趣的分子，其中所述第一表面的所述面积表现出至少一个自由基和/或离子实体。 本发明还涉及一种固体基质，其表面具有至少一个具有至少一个自由基和/或离子实体的区域，其具有至少一种粘附性，或至少一种粘附初级的前体， 其各种用途。
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7.发明申请METHOD FOR PREPARING AN ORGANIC FILM AT THE SURFACE OF A SOLID SUBSTRATEIN NON-ELECTROCHEMICAL CONDITIONS, SOLID SUBSTRATE THUS FORMED AND PREPARATION KIT 审中-公开在固体底物非电化学条件表面上制备有机膜的方法，该形成和制备试剂盒的固体基质
公开(公告)号：WO2008078052A2
公开(公告)日：2008-07-03
申请号：PCT/FR2007052556
申请日：2007-12-19
Applicant: COMMISSARIAT ENERGIE ATOMIQUE , MEVELLEC VINCENT , ROUSSEL SEBASTIEN , PALACIN SERGE , BERTHELOT THOMAS , BAUDIN CECILE , TRENGGONO ADHITYA , DENIAU GUY
Inventor： MEVELLEC VINCENT , ROUSSEL SEBASTIEN , PALACIN SERGE , BERTHELOT THOMAS , BAUDIN CECILE , TRENGGONO ADHITYA , DENIAU GUY
CPC classification number: C09D4/00 , B82Y30/00 , C08J7/02 , C08J7/04 , C23C18/04 , C23C18/08 , C23C18/14 , C23C18/28 , C23C18/31 , H01L51/0006 , H01L51/0021 , H01L51/0075 , Y10T428/31616 , Y10T428/31681
Abstract: The present invention relates to a method for preparing an organic film at the surface of a solid substrate, comprising a step of contacting said surface with a liquid solution containing (i) at least one solvent, at least one adhesion primer in non-electrochemical conditions and for generating radicalar entities from the adhesion primer. The liquid solution may further include (iii) at least one monomer different from the adhesion primer and polymerisable in a radicalar manner. The present invention also relates to an electrically non-conductive solid substrate on which an organic film is grafted according to said method, and to a kit for preparing an essentially polymeric organic film at the surface of the solid substrate.
Abstract translation: 本发明涉及一种在固体基质表面制备有机膜的方法，包括使所述表面与液体溶液接触的步骤，所述液体溶液含有（i）至少一种溶剂，至少一种非电化学条件下的粘合底漆 并用于从粘附底物产生真实实体。 液体溶液可以进一步包括（iii）至少一种不同于粘合引物的单体，并且可以以激进的方式聚合。 本发明还涉及根据所述方法在其上接枝有机膜的非导电固体基材，以及用于在固体基材表面制备基本上聚合的有机膜的试剂盒。
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公开(公告)号：FR3063817A1
公开(公告)日：2018-09-14
申请号：FR1751895
申请日：2017-03-08
Applicant: COMMISSARIAT ENERGIE ATOMIQUE
Inventor： CARRET GUILLAUME , BERTHELOT THOMAS , BERTHAULT PATRICK
IPC: G01R33/44 , G01R33/465 , G01R33/48
Abstract: Cellule de mesure (1) par résonance magnétique nucléaire en milieu liquide, comprenant: un réservoir (121) pour ledit milieu liquide; un circuit fluidique (122) relié audit réservoir et comprenant une chambre de mesure (124) ; un injecteur de gaz (130) débouchant dans ledit circuit fluidique, à distance de ladite chambre de mesure ; et une bobine (141) entourant ladite chambre de mesure ; caractérisée en ce qu'elle comprend également au moins un élément capacitif (142) formant, avec ladite bobine, un résonateur électromagnétique (140) ; et en ce qu'elle présente une forme permettant son introduction dans une sonde (2) de résonance magnétique nucléaire en remplacement d'un ensemble formé par un tube pour résonance magnétique nucléaire et un rotor portant ledit tube, la bobine (141) entourant la chambre de mesure étant alors positionnée de manière à se coupler par induction avec au moins une bobine à radiofréquence (20) de ladite sonde. Système de mesure par résonance magnétique nucléaire comprenant une telle cellule de mesure. Procédé de mesure par résonance magnétique utilisant une telle cellule.
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公开(公告)号：FR3050215B1
公开(公告)日：2018-04-13
申请号：FR1653345
申请日：2016-04-15
Applicant: COMMISSARIAT ENERGIE ATOMIQUE
Inventor： BOURLIER YOAN , BERTHELOT THOMAS
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10.发明专利
公开(公告)号：FR2984183B1
公开(公告)日：2016-07-01
申请号：FR1161722
申请日：2011-12-15
Applicant: COMMISSARIAT ENERGIE ATOMIQUE
Inventor： BERTHELOT THOMAS , VOLLAND HERVE
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