公开(公告)号：WO1996014843A2

公开(公告)日：1996-05-23

申请号：PCT/US1995014723

申请日：1995-11-09

Applicant: COR THERAPEUTICS, INC.

Inventor： COR THERAPEUTICS, INC. ,  GIESE, Neill, A. ,  LOKKER, Nathalie ,  LAIBELMAN, Alan, M. ,  SCARBOROUGH, Robert, M.

IPC: A61K31/415

CPC classification number: A61K31/455 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4439

Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of formula (I), wherein: R1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R3 is H or lower alkyl; R5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R6 is H or lower hydrocarboyl.

Abstract translation: 公开了选择性抑制激酶的方法，其包括将含有激酶的组合物与式（I）化合物接触，其中：R 1是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6- 多芳基，多芳基羰基，多杂芳基或多杂芳基羰基; R 2是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，低级烃基，5-或6-元杂环芳族羰基，多芳族或多杂芳族; R3是H或低级烷基; R5是H，低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，卤素或氰基; R6为H或低级烃基。

公开(公告)号：EP0846125A2

公开(公告)日：1998-06-10

申请号：EP96925254.0

申请日：1996-06-05

Applicant: COR THERAPEUTICS, INC.

Inventor： MARLOWE, Charles, K. ,  SCARBOROUGH, Robert, M. ,  LAIBELMAN, Alan, M. ,  SINHA, Uma ,  ZHU, Bing-Yan

IPC: A61K38 ,  A61P7 ,  C07C279 ,  C07C281 ,  C07C309 ,  C07C335 ,  C07K5

CPC classification number: C07K5/06095 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06086 ,  C07K5/06191

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.