公开(公告)号：WO9720045A3

公开(公告)日：1997-06-26

申请号：PCT/US9618175

申请日：1996-11-08

Applicant: COR THERAPEUTICS INC

Inventor： CONLEY PAMELA B ,  JANTZEN HANS-MICHAEL

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566

CPC classification number: G01N33/5091 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5094 ,  G01N33/566 ,  G01N2500/10

Abstract: Novel purinergic receptors are provided, having research, diagnostic and therapeutic applications. Also provided are nucleic acids encoding these receptors, as well as expression systems for their production.

公开(公告)号：AU3664401A

公开(公告)日：2001-08-14

申请号：AU3664401

申请日：2001-02-05

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M JR ,  JANTZEN HANS-MICHAEL ,  HUANG WOLIN ,  SEDLOCK DAVID M ,  MARLOWE CHARLES K

IPC: C07D239/48 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/4365 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D239/22 ,  C07D239/50 ,  C07D333/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D495/04 ,  C07D411/12 ,  C07D417/14 ,  A61K31/40 ,  A61K31/38 ,  A61K31/44 ,  A61K31/495 ,  A61K31/425 ,  A61K31/55 ,  C07D521/00

Abstract: Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.

公开(公告)号：CA2318199A1

公开(公告)日：1999-07-22

申请号：CA2318199

申请日：1999-01-08

Applicant: COR THERAPEUTICS INC

Inventor： LAIBELMAN ALAN M ,  JANTZEN HANS-MICHAEL ,  CONLEY PAMELA B ,  FRETTO LARRY J ,  SCARBOROUGH ROBERT M

IPC: A61K31/549 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/54 ,  C07D277/00 ,  C07D285/00

Abstract: The invention relates to novel compounds of formula (I) containing fused heterocyclic ring systems which are effective platelet ADP receptor inhibitors. Such compounds including pharmaceutically acceptable salts are useful in various pharmaceutical compositions for the prevention and/or treatment of cardiovascular disease particularly those related to thrombosis.

公开(公告)号：CA2237937A1

公开(公告)日：1997-06-05

申请号：CA2237937

申请日：1996-11-08

Applicant: COR THERAPEUTICS INC

Inventor： JANTZEN HANS-MICHAEL ,  CONLEY PAMELA B

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566

Abstract: Novel purinergic receptors are provided, having research, diagnostic and therapeutic applications. Also provided are nucleic acids encoding these receptors, as well as expression systems for their production.

公开(公告)号：AU729875B2

公开(公告)日：2001-02-15

申请号：AU1075397

申请日：1996-11-08

Applicant: COR THERAPEUTICS INC

Inventor： CONLEY PAMELA B ,  JANTZEN HANS-MICHAEL

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566

Abstract: Novel purinergic receptors are provided, having research, diagnostic and therapeutic applications. Also provided are nucleic acids encoding there receptors, as well as expression systems for their production.