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公开(公告)号：WO9640743A3
公开(公告)日：1997-01-23
申请号：PCT/US9609285
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC , MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING YAN
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: A61K38/00 , A61P7/02 , C07C279/24 , C07C281/06 , C07C309/30 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , A61K38/55
CPC classification number: C07K5/06095 , A61K38/00 , C07K5/06034 , C07K5/06086 , C07K5/06191
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：EP0766563A4
公开(公告)日：1998-10-21
申请号：EP95925461
申请日：1995-06-28
Applicant: COR THERAPEUTICS INC
Inventor： WOLF DAVID L , SINHA UMA
IPC: C12N15/09 , A61K38/00 , A61K38/43 , A61K38/46 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/64 , C12P21/00 , A61K35/16 , A61K38/36 , C07K1/08 , C12N9/48 , C12P21/04 , C12P21/06
CPC classification number: C12N9/6464 , A61K38/00 , C07K14/745 , C12N9/6432 , C12N9/647 , C12Y304/21006 , C12Y304/21069 , Y10S514/834 , Y10S530/83
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公开(公告)号：EP0631501A4
公开(公告)日：1995-12-27
申请号：EP93908307
申请日：1993-03-11
Applicant: COR THERAPEUTICS INC
Inventor： SINHA UMA , WOLF DAVID L
IPC: A61K38/36 , A61K38/00 , A61K38/17 , A61K38/43 , A61K38/47 , A61K39/395 , A61P7/02 , A61P29/00 , C07K14/42 , C07K14/745 , C07K16/36 , C12N9/64 , A61K35/78 , A61K35/80 , C07K3/00 , C07K14/00 , C07K15/00 , C07K17/00
CPC classification number: C12N9/6432 , A61K38/1709 , A61K38/47 , C07K14/42 , C07K14/745 , C07K16/36 , C12Y304/21006 , Y10S436/827
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公开(公告)号：DE69329333D1
公开(公告)日：2000-10-05
申请号：DE69329333
申请日：1993-03-11
Applicant: COR THERAPEUTICS INC
IPC: A61K38/36 , A61K38/00 , A61K38/17 , A61K38/43 , A61K38/47 , A61K39/395 , A61P7/02 , A61P29/00 , C07K14/42 , C07K14/745 , C07K16/36 , C12N9/64 , A61K35/78 , A61K38/56
Abstract: Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an alpha 2-6 linkage are able to inhibit the conversion of human Factor X to human Factor Xa. These reagents (SA/Gal/GalNAc binding reagents) as well as other strategies for inhibiting the conversion of Factor X to Factor Xa are useful in treating thrombosis, inflammation and other conditions associated with excess thrombin activity.
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公开(公告)号：NZ312840A
公开(公告)日：1999-11-29
申请号：NZ31284096
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: C07D277/24 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K38/00 , A61P7/02 , A61P9/00 , C07C311/64 , C07D263/14 , C07D263/56 , C07D277/68 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078 , C07K5/08
Abstract: The present invention relates to ketoheterocyclic containing compounds of the formula 1 which are inhibitors of the isolated factor Xa which treats a condition in a mammal characterised by undesired thrombosis. Also claimed is a pharmaceutical composition caused by thrombosis, and a method for inhibiting the coagulation of biological samples.
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Patent Agency Ranking
公开(公告)号：NZ313367A
公开(公告)日：1999-10-28
申请号：NZ31336796
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: A61P7/02 , C07C279/24 , C07C281/06 , C07C309/30 , A61K38/00 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , C07K5/10 , A61K38/55
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU6590296A
公开(公告)日：1996-12-30
申请号：AU6590296
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M JR , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: A61K38/00 , A61P7/02 , C07C279/24 , C07C281/06 , C07C309/30 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , A61K38/55
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：CA2224180A1
公开(公告)日：1996-12-19
申请号：CA2224180
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC
Inventor： SCARBOROUGH ROBERT M , ZHU BING-YAN , SINHA UMA , LAIBELMAN ALAN M , MARLOWE CHARLES K
IPC: C07D277/24 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K38/00 , A61P7/02 , A61P9/00 , C07C311/64 , C07D263/14 , C07D263/56 , C07D277/68 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078 , C07K5/08 , C07K5/09 , C07K5/027 , A61K38/06 , C07K5/097 , G01N1/28
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU717123B2
公开(公告)日：2000-03-16
申请号：AU4530997
申请日：1997-11-19
Applicant: COR THERAPEUTICS INC
Inventor： SINHA UMA , WOLF DAVID L
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10.发明专利
公开(公告)号：MX9709910A
公开(公告)日：1998-07-31
申请号：MX9709910
申请日：1997-12-08
Applicant: COR THERAPEUTICS INC
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: A61P7/02 , C07C279/24 , A61K38/00 , C07C281/06 , C07C309/30 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , C07K05/06 , A61K38/55
Abstract: Se describen compuestos novedosos, sus sales y composiciones relacionadas con los mismos que tienen actividad contra el factor Xa de mamífero; los compuestos son utiles in vitro o in vivo para prevenir o tratar trastornos de coagulacion.
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