公开(公告)号：DE69231128D1

公开(公告)日：2000-07-06

申请号：DE69231128

申请日：1992-01-28

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： ESCOBEDO A ,  WILLIAMS T ,  WOLF DAVID ,  TOMLINSON E ,  FRETTO J ,  GIESE A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：DE69231128T2

公开(公告)日：2001-02-15

申请号：DE69231128

申请日：1992-01-28

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： ESCOBEDO A ,  WILLIAMS T ,  WOLF DAVID ,  TOMLINSON E ,  FRETTO J ,  GIESE A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：AT193553T

公开(公告)日：2000-06-15

申请号：AT92906305

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  UNIV CALIFORNIA

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：ES2147729T3

公开(公告)日：2000-10-01

申请号：ES92906305

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  UNIV CALIFORNIA

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：DK0584082T3

公开(公告)日：2000-10-16

申请号：DK92906305

申请日：1992-01-28

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： WOLF DAVID ,  WILLIAMS LEWIS T ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCOBEDO JAIME A ,  TOMLINSON JAMES E

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  A01N1/02 ,  A61K37/02 ,  A61K38/18 ,  C07H15/12 ,  C07H17/00 ,  C07K3/00 ,  C07K13/00 ,  C07K14/475 ,  C07K15/00 ,  C07K17/00 ,  C12N5/00 ,  C12Q1/00 ,  C12Q1/68

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：AU709177B2

公开(公告)日：1999-08-26

申请号：AU5580496

申请日：1996-06-03

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：EP0619836A4

公开(公告)日：1996-12-04

申请号：EP93900825

申请日：1992-12-01

Applicant: COR THERAPEUTICS INC

Inventor： WOLF DAVID ,  TOMLINSON JAMES E

IPC: C12N5/00 ,  A61K38/00 ,  C07K14/71 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/27 ,  C12P21/00 ,  C12P21/02 ,  C12R1/91 ,  C07K1/00 ,  C12N15/00

CPC classification number: C07K14/71 ,  A61K38/00

公开(公告)号：EP0584082A4

公开(公告)日：1994-08-24

申请号：EP92906305

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/00

公开(公告)号：EP0547180A4

公开(公告)日：1994-11-23

申请号：EP91919100

申请日：1991-09-04

Applicant: COR THERAPEUTICS INC

Inventor： WOLF DAVID

IPC: A61K38/43 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/475 ,  C07K14/745 ,  C07K14/81 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12P21/02 ,  C07K13/00 ,  A61K35/14 ,  A61K37/02 ,  C07H15/12 ,  C07H17/00 ,  C12P21/06

CPC classification number: C12N9/647 ,  A61K38/00 ,  C07K14/745 ,  C12N9/6432 ,  C12Y304/21006

公开(公告)号：GR3034267T3

公开(公告)日：2000-12-29

申请号：GR20000401954

申请日：2000-08-30

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C07H15/12 ,  C07H17/00 ,  C07K3/00 ,  C07K13/00 ,  C07K15/00 ,  C07K17/00 ,  A01N1/02 ,  C12Q1/00 ,  C12Q1/68 ,  C12N5/00

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.