公开(公告)号：US3924947A

公开(公告)日：1975-12-09

申请号：US49617874

申请日：1974-08-09

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N1/28 ,  G01N15/10 ,  G01N15/14 ,  G01N33/48 ,  G01N33/49 ,  G06M11/00 ,  G06T1/00 ,  G01N33/16 ,  G01N21/00

CPC classification number: G01N15/1463 ,  G01N2001/282 ,  G01N2015/1037 ,  G01N2015/1093 ,  G01N2015/149

Abstract: An apparatus for identifying particles in a liquid suspension with respect to certain measured characteristics and matching the actual particles captured on a suitable substrate or the like member with their previously measured characteristics. One or more selected gross physical characteristics of individual particles are measured as the particles flow one by one in suspension through the sensing zone of a particle sensing device. The portion of the sample suspension which passes through the sensing zone subsequently is laid upon a substrate by a simple direct method which preserves the time relationships between the particles as they passed through the zone, there being a relative movement between the stream of the suspension and substrate. Since the portion of sample suspension which passes through the particle sensing zone carries the particles with it, these particles will be laid down upon the substrate in a scanning pattern wherein the sequence of temporal relationships between individual particles determines the sequence of spatial relationships between the individual particles in the scanning patterns. Assuming that a record is preserved of the time relationships between the sensed particles, it is feasible to measure the spaces between the particles laid onto the substrate and match the spatial relationships with the temporal relationships for locating the precise particles which produced certain measurements. In this manner observations of any captured particle can be added to characteristics measured on the identical particle to derive a substantial amount of information concerning that particle.

公开(公告)号：US3706030A

公开(公告)日：1972-12-12

申请号：US3706030D

申请日：1970-12-28

Applicant: COULTER ELECTRONICS

Inventor： KLEIN ROBERT I ,  HOGG WALTER R

IPC: G01N15/12 ,  G01N27/00

CPC classification number: G01N15/1227

Abstract: APPARATUS AND CIRCUITRY FOR ANALYZING PARTICLES SUSPENDED IN A FLUID MEDIUM, INCLUDING A FIRST INSULATED VESSEL HAVING A SMALL APERTURE OPENING INTO A SECOND INSULATED VESSEL, THE FLUID BEING IN BOTH VESSELS AND CAUSED TO PASS THROUGH THE APERTURE. AN EXCITATION POWER SUPPLY SOURCE OF A.C. OR D.C. TYPE PRODUCES AN ELECTRIC CURRENT BETWEEN THE TWO VESSELS, THE ELECTRICAL IMPEDANCE OF THE SUSPENSION BEING DIFFERENT FROM THAT OF THE PARTICLES, SO THAT A PARTICLE PASSING THROUGH THE APERTURE CHANGES THE IMPEDANCE OF THE APERTURE CONTENTS, THEREBY MODULATING THE CURRENT IN THE APERTURE CONTENTS, AND CAUSING A SIGNAL WHICH IS APPLIED TO THE INPUT OF A DETECTOR CIRCUIT COMPRISING AN AMPLIFIER. THE IMPEDANCE OF THE EXCITATION POWER SUPPLY SOURCE, THE IMPEDANCE OF THE EXCITATION AND THE IMPEDANCE OF THE APERTURE CONTENTS ARE DIMENSIONED AND ARRANGED IN SUCH A MANNER AS TO MAKE THE MAGNITUDES OF THE SIGNALS INDEPENDENT OF SLOW CHANGES IN ELECTRICAL CHARACTERISTICS OF THE SUSPENSION.

公开(公告)号：US3628140A

公开(公告)日：1971-12-14

申请号：US3628140D

申请日：1969-11-06

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  COULTER WALLACE H

IPC: G01N15/12 ,  G06M11/00

CPC classification number: G01N15/1218

Abstract: An aperture wafer which is adapted to be mounted to an aperture tube scanning element for use with a Coulter-type electronic particle counting and sizing apparatus. The wafer is formed of the usual materials such as ruby, sapphire and the like. The aperture is located substantially in the center of the wafer and dimensioned as conventionally formed apertures in known wafers, but differs from the prior art by having the body of the wafer thickened as much as feasible contiguously to the aperture. The configuration of the resulting structure provides a conical chamber leading to the aperture, which consequently is located at the apex of the chamber. The chamber and aperture are symmetrical about the aperture axis. The aperture wafer provides decreased capacitive losses and also focuses the field of the aperture giving increased resolution without substantial loss in sensitivity. The scanning element has the wafer mounted thereto with the chamber opening to the inside of the aperture tube.

公开(公告)号：US3439267A

公开(公告)日：1969-04-15

申请号：US3439267D

申请日：1965-10-20

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G01N33/487 ,  G01N33/49 ,  G01N27/02

CPC classification number: G01N33/49 ,  G01N15/12

Abstract: 1,162,941. Measuring hematocrit index of blood electrically. COULTER ELECTRONICS Ltd. Oct. 13, 1966 [Oct. 20, 1965], No.45896/66. Heading G1N. Apparatus for automatically measuring the ratio of the total volume of red cells of a given sample of whole blood to the total volume of that sample comprises a Coulter type of cell counting and sizing apparatus 10, having a first output channel 38 which delivers cell counting information to an integrator 23 and a second output channel 34 which delivers cell counting and cell sizing information to a mean cell volume computer 22, and an analog computer 75 for multiplying the cell count by the mean cell volume thereby to determine the hematocrit index. As shown in Fig. 1, a metering device 20, such as described in Specification 865, 069, delivers a known volume of a sample comprising blood diluted with an electrolyte to a Coulter scanner 12, such as described in Specification 907, 028. The output of integrator 23 is corrected in accordance with known statistics for coincidence (two cells being detected together) before being applied across terminals 71, 72 of a potentiometer 58. The wiper of the potentiometer is driven by a motor 49 forming part of a servoamplifier and its position is dependent on the mean cell volume whereby the voltage of the wiper tap 60 is proportional to the hematocrit index. This voltage is passed to a second servo-amplifier wherein the angular position of a scale 83 relative to an index mark 84 indicates the hematocrit index. A common reference voltage 63 is used for both servo-amplifiers. The integrator 23 may be arranged to de-energize the detecting means when the integrator has become saturated.

公开(公告)号：US3424897A

公开(公告)日：1969-01-28

申请号：US3424897D

申请日：1965-12-08

Applicant: COULTER ELECTRONICS

Inventor： MARCHESINI CESARE ,  HOGG WALTER R ,  KLEIN ROBERT I

IPC: G01N15/12 ,  G09G3/04 ,  G06F7/38

CPC classification number: G09G3/045 ,  G01N15/12

公开(公告)号：US3670150A

公开(公告)日：1972-06-13

申请号：US3670150D

申请日：1970-05-04

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  FIGUEROA DAVID R

IPC: G01N15/12 ,  H03G3/20 ,  H03K17/30 ,  H03K5/20

CPC classification number: H03G3/20 ,  G01N15/1227

Abstract: Generated pulses, having random amplitudes relative to particle sizes which lie in an especially wide range, are fed into a plurality of parallel channels, at the input of each of which there is an amplifier. Each amplifier has a different amplification factor and saturates in response to a correspondingly related maximum input pulse magnitude, so as to define a subrange of acceptable pulses. Saturation of a particular amplifier disables its channel and enables the adjacent, lower amplification, higher channel to accept or be saturated by the same pulse. Each pulse, when accepted by a channel, is further processed for particle analysis purposes. During the processing, the pulse amplitude is reduced by the same amplification factor as that of the accepting channel, so as to return all pulses to their initial relative amplitudes.

Abstract translation: 具有相对于特别宽范围内的粒度的随机幅度的生成脉冲在每个具有放大器的输入处被馈送到多个并行通道中。 每个放大器具有不同的放大因子并响应于相应的相关的最大输入脉冲幅度而饱和，以便限定可接受的脉冲的子范围。 特定放大器的饱和度禁用其通道，并使相邻，较低放大，较高通道接受或被相同脉冲饱和。 每个脉冲在被通道接受时被进一步处理以进行粒子分析。 在处理过程中，脉冲幅度减小了与接收通道相同的放大倍数，从而将所有脉冲返回到其初始相对幅度。

公开(公告)号：US3557352A

公开(公告)日：1971-01-19

申请号：US3557352D

申请日：1967-11-01

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  COULTER WALLACE H

IPC: G01D1/14 ,  G01N15/12 ,  G06M11/00 ,  G01N15/02

CPC classification number: G01N15/1227

Abstract: Apparatus which uses the Coulter particle analyzing system, converting the pulses obtained from said system into accumulated electrical quantities which may be compared to one another or to other quantities derived from the same system on the basis of which one can adjust the quantities relative to one another to achieve the size of a particle which divides the system into two fractional parts having a particular relationship to one another. A variation of this structure is one in which a particle size is obtained which establishes a point in the particulate system above or below which a predetermined fraction of the total mass exists. The preferred structure uses a threshold circuit responding to particle size and separating the electrical pulses produced by the particles being scanned in the Coulter apparatus through the use of such a threshold. The pulse trains are converted into current and these are compared, adjusting the threshold up and down until the desired relationship is reached in a comparison device. The level of the threshold being calibrated to particle size then represents the dividing size between the two fractions. One of the most useful pieces of information of this kind is the dividing size which is the mass median, in which the respective masses of particulate matter above and below the dividing size are equal to one another.

公开(公告)号：US3473010A

公开(公告)日：1969-10-14

申请号：US3473010D

申请日：1965-03-22

Applicant: COULTER ELECTRONICS

Inventor： BLOOMFIELD LEO B ,  HOGG WALTER R ,  COULTER WALLACE H ,  DORMAN ERVIN L

IPC: G01N15/12 ,  G01N33/49 ,  G06G7/48 ,  G06G7/50

CPC classification number: G01N15/1227

公开(公告)号：US3444464A

公开(公告)日：1969-05-13

申请号：US3444464D

申请日：1965-11-26

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G01R19/00 ,  H03K5/24 ,  G01N27/02 ,  G01N27/06

CPC classification number: G01R19/003 ,  G01N15/1245 ,  H03K5/24 ,  Y10S65/06 ,  Y10T137/4807

公开(公告)号：US3444463A

公开(公告)日：1969-05-13

申请号：US3444463D

申请日：1966-02-14

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G01R19/00 ,  H03K5/24 ,  G01N27/00 ,  G06F7/38 ,  G06G7/00

CPC classification number: G01R19/003 ,  G01N15/1245 ,  H03K5/24 ,  Y10S65/06 ,  Y10T137/4807